bmi5 posthoc analysis
Updated on 2022-02-28
Description
Follow-up analyses of GWIS findings
- Table of significant and suggestive (1df GxE only)
bmi5GWIS findings
- GxE models stratified by study_design and tumor site (proximal, distal, rectal)
- GxE models with additional covariate sets (might do this for aspirin ..)
- Odds ratios stratified by exposure and genotype
- Plots of model predicted outcome by 1 unit increase of exposure/allelic dosage
- Locuszoom plot
- Functional annotation plot
Suggestive GxE findings
chr11_120531547_C_G
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr11_120531547_C_G_dose | 0.726*** (0.597, 0.854) | 0.726*** (0.558, 0.893) | 0.710*** (0.508, 0.912) |
| bmi5 | 1.068*** (1.035, 1.101) | 1.026 (0.983, 1.069) | 1.129*** (1.077, 1.181) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.003, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.110*** (1.079, 1.141) | ||
| chr11_120531547_C_G_dose:bmi5 | 1.058*** (1.035, 1.082) | 1.064*** (1.034, 1.095) | 1.057** (1.021, 1.094) |
| Constant | 1.963** (1.529, 2.396) | 0.643** (0.338, 0.947) | 1.519 (1.024, 2.014) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 1.6055e-06 | |||
| GxE term LRtest p = 5.5872e-05 | |||
| GxE term LRtest p = 2.6517e-03 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr11_120531547_C_G_dose | 0.726*** (0.597, 0.854) | 0.735** (0.548, 0.921) | 0.717*** (0.539, 0.894) |
| bmi5 | 1.068*** (1.035, 1.101) | 1.067** (1.018, 1.116) | 1.068** (1.023, 1.114) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.110*** (1.079, 1.141) | 1.165*** (1.116, 1.214) | 1.074*** (1.033, 1.114) |
| chr11_120531547_C_G_dose:bmi5 | 1.058*** (1.035, 1.082) | 1.057** (1.024, 1.091) | 1.060*** (1.028, 1.092) |
| Constant | 1.963** (1.529, 2.396) | 2.160** (1.661, 2.658) | 0.482*** (0.187, 0.777) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 1.6055e-06 | |||
| GxE term LRtest p = 1.2021e-03 | |||
| GxE term LRtest p = 3.8706e-04 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr11_120531547_C_G_dose | 0.726*** (0.597, 0.854) | 0.745** (0.543, 0.947) | 0.804* (0.610, 0.999) | 0.712** (0.496, 0.929) |
| bmi5 | 1.068*** (1.035, 1.101) | 1.129*** (1.077, 1.181) | 1.093*** (1.042, 1.143) | 1.011 (0.954, 1.068) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.020*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.110*** (1.079, 1.141) | 1.060* (1.010, 1.109) | 0.843*** (0.795, 0.892) | 1.301*** (1.250, 1.352) |
| chr11_120531547_C_G_dose:bmi5 | 1.058*** (1.035, 1.082) | 1.050** (1.014, 1.086) | 1.042* (1.007, 1.077) | 1.064** (1.025, 1.103) |
| Constant | 1.963** (1.529, 2.396) | 0.637 (0.054, 1.219) | 0.259*** (-0.311, 0.830) | 2.796*** (2.258, 3.333) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 1.6055e-06 | ||||
| GxE term LRtest p = 7.8067e-03 | ||||
| GxE term LRtest p = 2.0831e-02 | ||||
| GxE term LRtest p = 1.9867e-03 | ||||
Stratified OR
| CC | CG | GG | CG | GG | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 0.98 (0.91-1.07) | 0.9 (0.83-0.98) | 0.98 (0.91-1.07) | 0.9 (0.83-0.98) | 1652.3/2267.7 | 5495.9/7743.9 | 4721.8/7233.4 |
| p0 | P= 1 | P= 0.71 | P= 0.013 | P= 0.71 | P= 0.013 | |||
| bmic3f=Overweight | 1.08 (0.98-1.18) | 1.08 (1-1.17) | 1.05 (0.97-1.13) | 1.01 (0.94-1.08) | 0.98 (0.91-1.05) | 2087.8/2748.9 | 7202/9570.1 | 6168.2/8360 |
| p1 | P= 0.13 | P= 0.046 | P= 0.24 | P= 0.86 | P= 0.5 | |||
| bmic3f=Obese | 1.21 (1.09-1.36) | 1.26 (1.16-1.37) | 1.39 (1.28-1.51) | 1.04 (0.94-1.15) | 1.14 (1.04-1.26) | 1201.6/1461.8 | 4099.9/4896.2 | 3785.5/4169 |
| p2 | P= 0.00057 | P= 4.8e-08 | P= 3.5e-14 | P= 0.44 | P= 0.0069 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.08 (0.98-1.18) | 1.1 (1.04-1.16) | 1.16 (1.1-1.22) | |||||
| p1 (G) | P= 0.13 | P= 0.00027 | P= 4.9e-08 | |||||
| bmic3f=Obese(G) | 1.21 (1.09-1.36) | 1.28 (1.21-1.36) | 1.54 (1.44-1.64) | |||||
| p2 (G) | P= 0.00057 | P= 3e-16 | P= 1.9e-41 | |||||
Stratified OR (adj smk_ever)
| CC | CG | GG | CG | GG | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 0.99 (0.91-1.08) | 0.92 (0.84-0.99) | 0.99 (0.91-1.08) | 0.92 (0.84-0.99) | 1605.6/2244.1 | 5352.5/7642.9 | 4615.9/7129 |
| p0 | P= 1 | P= 0.82 | P= 0.033 | P= 0.82 | P= 0.033 | |||
| bmic3f=Overweight | 1.09 (1-1.2) | 1.1 (1.01-1.18) | 1.07 (0.98-1.15) | 1 (0.93-1.08) | 0.97 (0.9-1.05) | 2038.5/2700.5 | 7011.7/9430.8 | 6022.7/8225.7 |
| p1 | P= 0.063 | P= 0.024 | P= 0.12 | P= 0.99 | P= 0.47 | |||
| bmic3f=Obese | 1.24 (1.1-1.38) | 1.29 (1.19-1.4) | 1.41 (1.29-1.53) | 1.04 (0.95-1.15) | 1.14 (1.03-1.26) | 1171/1437.4 | 4007.8/4813.2 | 3706.2/4115.4 |
| p2 | P= 0.00021 | P= 3.8e-09 | P= 6.8e-15 | P= 0.39 | P= 0.0097 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.09 (1-1.2) | 1.11 (1.05-1.16) | 1.16 (1.1-1.23) | |||||
| p1 (G) | P= 0.063 | P= 0.00013 | P= 3.6e-08 | |||||
| bmic3f=Obese(G) | 1.24 (1.1-1.38) | 1.3 (1.23-1.38) | 1.54 (1.44-1.64) | |||||
| p2 (G) | P= 0.00021 | P= 9.2e-18 | P= 1.2e-40 | |||||
Locuszoom
Func Annot
chr11_46574459_T_A
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr11_46574459_T_A_dose | 0.509*** (0.218, 0.800) | 0.466*** (0.084, 0.847) | 0.596* (0.142, 1.049) |
| bmi5 | 1.133*** (1.117, 1.150) | 1.094*** (1.073, 1.115) | 1.199*** (1.173, 1.225) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.004, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.111*** (1.079, 1.142) | ||
| chr11_46574459_T_A_dose:bmi5 | 1.136*** (1.083, 1.188) | 1.159*** (1.090, 1.228) | 1.101* (1.019, 1.183) |
| Constant | 1.403 (1.000, 1.806) | 0.461*** (0.238, 0.683) | 1.043 (0.616, 1.471) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 1.9279e-06 | |||
| GxE term LRtest p = 2.4866e-05 | |||
| GxE term LRtest p = 2.1045e-02 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr11_46574459_T_A_dose | 0.509*** (0.218, 0.800) | 0.559* (0.103, 1.015) | 0.478*** (0.096, 0.860) |
| bmi5 | 1.133*** (1.117, 1.150) | 1.135*** (1.112, 1.159) | 1.130*** (1.108, 1.153) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.111*** (1.079, 1.142) | 1.165*** (1.116, 1.214) | 1.075*** (1.034, 1.116) |
| chr11_46574459_T_A_dose:bmi5 | 1.136*** (1.083, 1.188) | 1.107* (1.024, 1.190) | 1.156*** (1.087, 1.225) |
| Constant | 1.403 (1.000, 1.806) | 1.537 (1.096, 1.979) | 0.344*** (0.147, 0.541) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 1.9279e-06 | |||
| GxE term LRtest p = 1.5750e-02 | |||
| GxE term LRtest p = 3.3168e-05 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr11_46574459_T_A_dose | 0.509*** (0.218, 0.800) | 0.583* (0.127, 1.039) | 0.509** (0.074, 0.943) | 0.383*** (-0.079, 0.844) |
| bmi5 | 1.133*** (1.117, 1.150) | 1.189*** (1.164, 1.215) | 1.137*** (1.112, 1.161) | 1.071*** (1.043, 1.099) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.020*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.111*** (1.079, 1.142) | 1.060* (1.010, 1.109) | 0.844*** (0.795, 0.892) | 1.301*** (1.250, 1.352) |
| chr11_46574459_T_A_dose:bmi5 | 1.136*** (1.083, 1.188) | 1.106* (1.024, 1.187) | 1.136** (1.058, 1.214) | 1.211*** (1.128, 1.294) |
| Constant | 1.403 (1.000, 1.806) | 0.467** (-0.060, 0.993) | 0.211*** (-0.307, 0.728) | 2.019** (1.554, 2.483) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 1.9279e-06 | ||||
| GxE term LRtest p = 1.6093e-02 | ||||
| GxE term LRtest p = 1.3937e-03 | ||||
| GxE term LRtest p = 6.2685e-06 | ||||
Stratified OR
| TT | TA | AA | TA | AA | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 0.84 (0.77-0.92) | 1.22 (0.77-1.94) | 0.84 (0.77-0.92) | 1.22 (0.77-1.94) | 10767.5/15529.1 | 1057.7/1664.1 | 44.8/51.8 |
| p0 | P= 1 | P= 0.00012 | P= 0.4 | P= 0.00012 | P= 0.4 | |||
| bmic3f=Overweight | 1.1 (1.06-1.14) | 1.15 (1.06-1.24) | 1.69 (1.11-2.6) | 1.05 (0.97-1.13) | 1.55 (1.01-2.37) | 13870.9/18768 | 1524.5/1858.6 | 62.6/52.3 |
| p1 | P= 3.6e-07 | P= 0.00081 | P= 0.016 | P= 0.26 | P= 0.046 | |||
| bmic3f=Obese | 1.33 (1.27-1.38) | 1.53 (1.37-1.7) | 2.19 (1.24-3.86) | 1.15 (1.03-1.28) | 1.65 (0.93-2.91) | 8114.1/9600.4 | 932/900 | 40.9/26.6 |
| p2 | P= 4.1e-41 | P= 5.9e-15 | P= 0.007 | P= 0.011 | P= 0.086 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.1 (1.06-1.14) | 1.37 (1.22-1.54) | 1.39 (0.74-2.61) | |||||
| p1 (G) | P= 3.6e-07 | P= 6e-08 | P= 0.31 | |||||
| bmic3f=Obese(G) | 1.33 (1.27-1.38) | 1.83 (1.6-2.09) | 1.79 (0.86-3.73) | |||||
| p2 (G) | P= 4.1e-41 | P= 1e-18 | P= 0.12 | |||||
Stratified OR (adj smk_ever)
| TT | TA | AA | TA | AA | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 0.84 (0.77-0.93) | 1.25 (0.79-1.99) | 0.84 (0.77-0.93) | 1.25 (0.79-1.99) | 10495.2/15328.6 | 1034/1635.6 | 44.8/51.8 |
| p0 | P= 1 | P= 0.00028 | P= 0.35 | P= 0.00028 | P= 0.35 | |||
| bmic3f=Overweight | 1.1 (1.07-1.14) | 1.16 (1.07-1.25) | 1.7 (1.11-2.6) | 1.05 (0.97-1.14) | 1.54 (1-2.36) | 13512/18464.8 | 1498.5/1839.8 | 62.5/52.3 |
| p1 | P= 6.1e-08 | P= 0.00044 | P= 0.015 | P= 0.26 | P= 0.048 | |||
| bmic3f=Obese | 1.34 (1.29-1.4) | 1.55 (1.39-1.73) | 2.37 (1.33-4.22) | 1.16 (1.04-1.29) | 1.77 (0.99-3.15) | 7927.7/9456.5 | 916.5/883.8 | 40.8/25.7 |
| p2 | P= 6.3e-43 | P= 1.2e-15 | P= 0.0033 | P= 0.0094 | P= 0.053 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.1 (1.07-1.14) | 1.37 (1.22-1.54) | 1.36 (0.72-2.55) | |||||
| p1 (G) | P= 6.1e-08 | P= 8.1e-08 | P= 0.34 | |||||
| bmic3f=Obese(G) | 1.34 (1.29-1.4) | 1.84 (1.61-2.1) | 1.9 (0.91-3.97) | |||||
| p2 (G) | P= 6.3e-43 | P= 9.3e-19 | P= 0.089 | |||||
Locuszoom
Func Annot
chr11_47328213_T_C
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr11_47328213_T_C_dose | 0.425*** (0.088, 0.762) | 0.339*** (-0.109, 0.786) | 0.594* (0.076, 1.112) |
| bmi5 | 1.135*** (1.118, 1.151) | 1.094*** (1.073, 1.115) | 1.202*** (1.177, 1.228) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.003, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.110*** (1.079, 1.142) | ||
| chr11_47328213_T_C_dose:bmi5 | 1.173*** (1.112, 1.235) | 1.228*** (1.147, 1.310) | 1.101* (1.007, 1.195) |
| Constant | 1.397 (0.994, 1.800) | 0.461*** (0.240, 0.683) | 1.031 (0.604, 1.458) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 2.4160e-07 | |||
| GxE term LRtest p = 5.2529e-07 | |||
| GxE term LRtest p = 4.3252e-02 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr11_47328213_T_C_dose | 0.425*** (0.088, 0.762) | 0.427** (-0.107, 0.962) | 0.423*** (-0.013, 0.860) |
| bmi5 | 1.135*** (1.118, 1.151) | 1.135*** (1.111, 1.158) | 1.133*** (1.111, 1.156) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.110*** (1.079, 1.142) | 1.165*** (1.116, 1.214) | 1.074*** (1.033, 1.115) |
| chr11_47328213_T_C_dose:bmi5 | 1.173*** (1.112, 1.235) | 1.169** (1.072, 1.266) | 1.176*** (1.097, 1.255) |
| Constant | 1.397 (0.994, 1.800) | 1.541 (1.099, 1.982) | 0.341*** (0.145, 0.537) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 2.4160e-07 | |||
| GxE term LRtest p = 1.5831e-03 | |||
| GxE term LRtest p = 4.7385e-05 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr11_47328213_T_C_dose | 0.425*** (0.088, 0.762) | 0.425** (-0.103, 0.954) | 0.345*** (-0.157, 0.846) | 0.457** (-0.083, 0.997) |
| bmi5 | 1.135*** (1.118, 1.151) | 1.187*** (1.162, 1.213) | 1.134*** (1.110, 1.159) | 1.081*** (1.054, 1.108) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.020*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.110*** (1.079, 1.142) | 1.059* (1.009, 1.109) | 0.844*** (0.795, 0.892) | 1.300*** (1.250, 1.351) |
| chr11_47328213_T_C_dose:bmi5 | 1.173*** (1.112, 1.235) | 1.173*** (1.079, 1.268) | 1.223*** (1.133, 1.313) | 1.162** (1.064, 1.259) |
| Constant | 1.397 (0.994, 1.800) | 0.470** (-0.055, 0.996) | 0.213*** (-0.304, 0.730) | 1.930** (1.466, 2.393) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 2.4160e-07 | ||||
| GxE term LRtest p = 9.2266e-04 | ||||
| GxE term LRtest p = 1.1511e-05 | ||||
| GxE term LRtest p = 2.6590e-03 | ||||
Stratified OR
| TT | TC | CC | TC | CC | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 0.85 (0.77-0.94) | 1.02 (0.57-1.85) | 0.85 (0.77-0.94) | 1.02 (0.57-1.85) | 11020.6/15925.1 | 823.3/1287.6 | 26.1/32.4 |
| p0 | P= 1 | P= 0.0018 | P= 0.93 | P= 0.0018 | P= 0.93 | |||
| bmic3f=Overweight | 1.1 (1.07-1.14) | 1.16 (1.06-1.27) | 1.4 (0.79-2.47) | 1.05 (0.96-1.15) | 1.26 (0.72-2.24) | 14270/19265.8 | 1155.4/1382.4 | 32.6/30.8 |
| p1 | P= 3.3e-08 | P= 0.0017 | P= 0.25 | P= 0.31 | P= 0.42 | |||
| bmic3f=Obese | 1.34 (1.28-1.39) | 1.62 (1.44-1.83) | 1.37 (0.66-2.85) | 1.22 (1.07-1.38) | 1.03 (0.5-2.13) | 8356.6/9859.6 | 710/649.3 | 20.4/18.1 |
| p2 | P= 5.9e-44 | P= 7.7e-15 | P= 0.39 | P= 0.0021 | P= 0.94 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.1 (1.07-1.14) | 1.36 (1.19-1.55) | 1.36 (0.6-3.09) | |||||
| p1 (G) | P= 3.3e-08 | P= 3.6e-06 | P= 0.46 | |||||
| bmic3f=Obese(G) | 1.34 (1.28-1.39) | 1.91 (1.64-2.22) | 1.34 (0.53-3.42) | |||||
| p2 (G) | P= 5.9e-44 | P= 1.4e-16 | P= 0.54 | |||||
Stratified OR (adj smk_ever)
| TT | TC | CC | TC | CC | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 0.86 (0.78-0.96) | 1.07 (0.59-1.94) | 0.86 (0.78-0.96) | 1.07 (0.59-1.94) | 10738.4/15720 | 809.5/1264 | 26.1/32 |
| p0 | P= 1 | P= 0.0053 | P= 0.82 | P= 0.0053 | P= 0.82 | |||
| bmic3f=Overweight | 1.11 (1.07-1.15) | 1.16 (1.06-1.27) | 1.41 (0.8-2.49) | 1.04 (0.95-1.14) | 1.27 (0.72-2.24) | 13909.4/18959.9 | 1131.1/1366.4 | 32.5/30.7 |
| p1 | P= 3.7e-09 | P= 0.0015 | P= 0.24 | P= 0.36 | P= 0.42 | |||
| bmic3f=Obese | 1.35 (1.3-1.41) | 1.63 (1.44-1.84) | 1.5 (0.71-3.15) | 1.21 (1.07-1.37) | 1.11 (0.53-2.34) | 8167.6/9708.4 | 697.2/640.5 | 20.3/17.1 |
| p2 | P= 3e-46 | P= 7e-15 | P= 0.29 | P= 0.0031 | P= 0.78 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.11 (1.07-1.15) | 1.34 (1.18-1.53) | 1.31 (0.58-2.98) | |||||
| p1 (G) | P= 3.7e-09 | P= 1.1e-05 | P= 0.51 | |||||
| bmic3f=Obese(G) | 1.35 (1.3-1.41) | 1.89 (1.62-2.2) | 1.4 (0.54-3.62) | |||||
| p2 (G) | P= 3e-46 | P= 8.1e-16 | P= 0.49 | |||||
Locuszoom
Func Annot
chr15_33122966_C_T
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr15_33122966_C_T_dose | 1.501*** (1.352, 1.649) | 1.521*** (1.329, 1.713) | 1.456** (1.220, 1.691) |
| bmi5 | 1.178*** (1.159, 1.197) | 1.139*** (1.114, 1.164) | 1.240*** (1.210, 1.271) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.003, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.110*** (1.078, 1.141) | ||
| chr15_33122966_C_T_dose:bmi5 | 0.939*** (0.913, 0.966) | 0.939*** (0.904, 0.974) | 0.944** (0.902, 0.987) |
| Constant | 1.116 (0.709, 1.523) | 0.360*** (0.127, 0.593) | 0.850 (0.414, 1.287) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 4.9681e-06 | |||
| GxE term LRtest p = 3.7163e-04 | |||
| GxE term LRtest p = 7.9671e-03 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr15_33122966_C_T_dose | 1.501*** (1.352, 1.649) | 1.584*** (1.369, 1.799) | 1.427*** (1.222, 1.632) |
| bmi5 | 1.178*** (1.159, 1.197) | 1.180*** (1.152, 1.208) | 1.175*** (1.149, 1.201) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.110*** (1.078, 1.141) | 1.165*** (1.116, 1.214) | 1.073*** (1.032, 1.114) |
| chr15_33122966_C_T_dose:bmi5 | 0.939*** (0.913, 0.966) | 0.932*** (0.893, 0.971) | 0.946** (0.909, 0.983) |
| Constant | 1.116 (0.709, 1.523) | 1.215 (0.766, 1.665) | 0.274*** (0.064, 0.484) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 4.9681e-06 | |||
| GxE term LRtest p = 4.0843e-04 | |||
| GxE term LRtest p = 3.3760e-03 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr15_33122966_C_T_dose | 1.501*** (1.352, 1.649) | 1.548*** (1.315, 1.782) | 1.528*** (1.304, 1.751) | 1.562*** (1.314, 1.810) |
| bmi5 | 1.178*** (1.159, 1.197) | 1.237*** (1.207, 1.266) | 1.183*** (1.155, 1.212) | 1.124*** (1.092, 1.156) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.020*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.110*** (1.078, 1.141) | 1.059* (1.009, 1.109) | 0.843*** (0.794, 0.891) | 1.299*** (1.248, 1.350) |
| chr15_33122966_C_T_dose:bmi5 | 0.939*** (0.913, 0.966) | 0.931*** (0.889, 0.973) | 0.935** (0.895, 0.975) | 0.936** (0.891, 0.981) |
| Constant | 1.116 (0.709, 1.523) | 0.370*** (-0.164, 0.903) | 0.165*** (-0.359, 0.690) | 1.528 (1.056, 2.001) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 4.9681e-06 | ||||
| GxE term LRtest p = 7.3858e-04 | ||||
| GxE term LRtest p = 1.0582e-03 | ||||
| GxE term LRtest p = 3.8049e-03 | ||||
Stratified OR
| CC | CT | TT | CT | TT | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.12 (1.06-1.18) | 1.26 (1.12-1.43) | 1.12 (1.06-1.18) | 1.26 (1.12-1.43) | 7382/11094.8 | 3938.6/5459 | 549.5/691.3 |
| p0 | P= 1 | P= 4.3e-05 | P= 0.0002 | P= 4.3e-05 | P= 0.0002 | |||
| bmic3f=Overweight | 1.13 (1.08-1.18) | 1.25 (1.19-1.31) | 1.28 (1.14-1.43) | 1.1 (1.05-1.16) | 1.13 (1.01-1.27) | 9678.1/13327.5 | 5114.5/6524.9 | 665.5/826.6 |
| p1 | P= 7.7e-09 | P= 4e-18 | P= 1.7e-05 | P= 5.8e-05 | P= 0.029 | |||
| bmic3f=Obese | 1.45 (1.38-1.52) | 1.43 (1.34-1.52) | 1.26 (1.09-1.47) | 0.99 (0.92-1.05) | 0.87 (0.75-1.02) | 5812.3/6625.6 | 2924.4/3436.3 | 350.2/465.1 |
| p2 | P= 3.9e-50 | P= 2.9e-30 | P= 0.0022 | P= 0.65 | P= 0.077 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.13 (1.08-1.18) | 1.12 (1.05-1.18) | 1.02 (0.86-1.19) | |||||
| p1 (G) | P= 7.7e-09 | P= 0.00021 | P= 0.85 | |||||
| bmic3f=Obese(G) | 1.45 (1.38-1.52) | 1.28 (1.19-1.37) | 1 (0.83-1.21) | |||||
| p2 (G) | P= 3.9e-50 | P= 1.5e-12 | P= 0.98 | |||||
Stratified OR (adj smk_ever)
| CC | CT | TT | CT | TT | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.11 (1.06-1.18) | 1.28 (1.13-1.45) | 1.11 (1.06-1.18) | 1.28 (1.13-1.45) | 7196.4/10942.9 | 3834.3/5391.8 | 543.3/681.3 |
| p0 | P= 1 | P= 8.5e-05 | P= 8.9e-05 | P= 8.5e-05 | P= 8.9e-05 | |||
| bmic3f=Overweight | 1.14 (1.09-1.19) | 1.25 (1.19-1.32) | 1.28 (1.15-1.44) | 1.1 (1.05-1.15) | 1.13 (1.01-1.26) | 9441.2/13112.5 | 4987.3/6432.6 | 644.5/811.9 |
| p1 | P= 1.5e-09 | P= 2.4e-18 | P= 1.7e-05 | P= 0.00012 | P= 0.038 | |||
| bmic3f=Obese | 1.46 (1.39-1.54) | 1.44 (1.36-1.54) | 1.29 (1.11-1.5) | 0.99 (0.93-1.05) | 0.88 (0.76-1.03) | 5680.3/6533.6 | 2860.4/3376.3 | 344.2/456.1 |
| p2 | P= 4.2e-51 | P= 2.4e-31 | P= 0.00098 | P= 0.72 | P= 0.11 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.14 (1.09-1.19) | 1.12 (1.06-1.19) | 1 (0.85-1.18) | |||||
| p1 (G) | P= 1.5e-09 | P= 9.6e-05 | P= 0.96 | |||||
| bmic3f=Obese(G) | 1.46 (1.39-1.54) | 1.3 (1.21-1.39) | 1.01 (0.83-1.22) | |||||
| p2 (G) | P= 4.2e-51 | P= 1.5e-13 | P= 0.93 | |||||
Locuszoom
Func Annot
chr2_10961902_T_C
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr2_10961902_T_C_dose | 1.359*** (1.224, 1.493) | 1.389*** (1.215, 1.564) | 1.308* (1.095, 1.520) |
| bmi5 | 1.185*** (1.165, 1.206) | 1.150*** (1.123, 1.176) | 1.246*** (1.214, 1.278) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.003, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.110*** (1.078, 1.141) | ||
| chr2_10961902_T_C_dose:bmi5 | 0.942*** (0.918, 0.967) | 0.938*** (0.906, 0.969) | 0.949** (0.911, 0.987) |
| Constant | 1.116 (0.707, 1.524) | 0.359*** (0.121, 0.597) | 0.860 (0.420, 1.301) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 1.5633e-06 | |||
| GxE term LRtest p = 6.8194e-05 | |||
| GxE term LRtest p = 7.3187e-03 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr2_10961902_T_C_dose | 1.359*** (1.224, 1.493) | 1.360** (1.164, 1.556) | 1.359** (1.173, 1.544) |
| bmi5 | 1.185*** (1.165, 1.206) | 1.184*** (1.154, 1.213) | 1.186*** (1.158, 1.214) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.110*** (1.078, 1.141) | 1.165*** (1.116, 1.214) | 1.073*** (1.033, 1.114) |
| chr2_10961902_T_C_dose:bmi5 | 0.942*** (0.918, 0.967) | 0.941*** (0.906, 0.977) | 0.943*** (0.910, 0.976) |
| Constant | 1.116 (0.707, 1.524) | 1.241 (0.788, 1.693) | 0.270*** (0.053, 0.486) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 1.5633e-06 | |||
| GxE term LRtest p = 8.2868e-04 | |||
| GxE term LRtest p = 5.6437e-04 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr2_10961902_T_C_dose | 1.359*** (1.224, 1.493) | 1.308* (1.096, 1.519) | 1.566*** (1.362, 1.771) | 1.253 (1.026, 1.480) |
| bmi5 | 1.185*** (1.165, 1.206) | 1.237*** (1.205, 1.268) | 1.207*** (1.177, 1.237) | 1.121*** (1.086, 1.155) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.020*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.110*** (1.078, 1.141) | 1.059* (1.009, 1.109) | 0.843*** (0.794, 0.891) | 1.300*** (1.249, 1.350) |
| chr2_10961902_T_C_dose:bmi5 | 0.942*** (0.918, 0.967) | 0.948** (0.910, 0.986) | 0.916*** (0.879, 0.953) | 0.956* (0.915, 0.998) |
| Constant | 1.116 (0.707, 1.524) | 0.382*** (-0.154, 0.918) | 0.155*** (-0.372, 0.683) | 1.608 (1.130, 2.085) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 1.5633e-06 | ||||
| GxE term LRtest p = 5.2914e-03 | ||||
| GxE term LRtest p = 2.9088e-06 | ||||
| GxE term LRtest p = 3.3274e-02 | ||||
Stratified OR
| TT | TC | CC | TC | CC | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.02 (0.97-1.08) | 1.03 (0.93-1.13) | 1.02 (0.97-1.08) | 1.03 (0.93-1.13) | 6390/9412.3 | 4621.9/6605.9 | 858.1/1226.8 |
| p0 | P= 1 | P= 0.39 | P= 0.56 | P= 0.39 | P= 0.56 | |||
| bmic3f=Overweight | 1.14 (1.09-1.2) | 1.12 (1.06-1.17) | 1.15 (1.05-1.25) | 0.98 (0.93-1.02) | 1.01 (0.92-1.1) | 8331.7/11075.1 | 5968.5/8062.2 | 1157.8/1541.7 |
| p1 | P= 7e-09 | P= 1e-05 | P= 0.0017 | P= 0.32 | P= 0.89 | |||
| bmic3f=Obese | 1.45 (1.38-1.53) | 1.34 (1.26-1.42) | 1.2 (1.07-1.35) | 0.92 (0.87-0.98) | 0.83 (0.74-0.93) | 4967.1/5535.6 | 3484.8/4165.2 | 635.1/826.2 |
| p2 | P= 5e-43 | P= 2.8e-22 | P= 0.0015 | P= 0.01 | P= 0.0018 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.14 (1.09-1.2) | 1.09 (1.03-1.15) | 1.12 (0.99-1.26) | |||||
| p1 (G) | P= 7e-09 | P= 0.0013 | P= 0.075 | |||||
| bmic3f=Obese(G) | 1.45 (1.38-1.53) | 1.31 (1.23-1.39) | 1.17 (1.01-1.35) | |||||
| p2 (G) | P= 5e-43 | P= 3.8e-17 | P= 0.031 | |||||
Stratified OR (adj smk_ever)
| TT | TC | CC | TC | CC | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.02 (0.97-1.08) | 1.03 (0.93-1.13) | 1.02 (0.97-1.08) | 1.03 (0.93-1.13) | 6232/9280.7 | 4508.2/6521.6 | 833.9/1213.8 |
| p0 | P= 1 | P= 0.42 | P= 0.59 | P= 0.42 | P= 0.59 | |||
| bmic3f=Overweight | 1.15 (1.1-1.2) | 1.12 (1.07-1.18) | 1.15 (1.05-1.25) | 0.98 (0.93-1.02) | 1 (0.91-1.09) | 8136.1/10909.1 | 5820/7932.2 | 1116.9/1515.7 |
| p1 | P= 1.8e-09 | P= 4.8e-06 | P= 0.0024 | P= 0.3 | P= 0.95 | |||
| bmic3f=Obese | 1.46 (1.39-1.54) | 1.35 (1.27-1.43) | 1.2 (1.07-1.35) | 0.92 (0.87-0.98) | 0.82 (0.73-0.92) | 4859/5447.7 | 3405.9/4101.4 | 620/816.9 |
| p2 | P= 5.2e-44 | P= 1.9e-23 | P= 0.0018 | P= 0.014 | P= 0.0011 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.15 (1.1-1.2) | 1.1 (1.04-1.16) | 1.12 (0.99-1.26) | |||||
| p1 (G) | P= 1.8e-09 | P= 0.00061 | P= 0.08 | |||||
| bmic3f=Obese(G) | 1.46 (1.39-1.54) | 1.32 (1.24-1.41) | 1.17 (1.01-1.35) | |||||
| p2 (G) | P= 5.2e-44 | P= 2.5e-18 | P= 0.033 | |||||
Locuszoom
Func Annot
chr2_217410559_G_A
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr2_217410559_G_A_dose | 2.182*** (1.833, 2.531) | 2.238*** (1.785, 2.691) | 2.037* (1.484, 2.590) |
| bmi5 | 1.159*** (1.143, 1.175) | 1.122*** (1.101, 1.142) | 1.222*** (1.197, 1.247) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.003, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.110*** (1.078, 1.141) | ||
| chr2_217410559_G_A_dose:bmi5 | 0.859*** (0.796, 0.922) | 0.854*** (0.772, 0.936) | 0.870** (0.771, 0.970) |
| Constant | 1.247 (0.844, 1.650) | 0.407*** (0.186, 0.628) | 0.946 (0.519, 1.372) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 2.1518e-06 | |||
| GxE term LRtest p = 1.5376e-04 | |||
| GxE term LRtest p = 6.2497e-03 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr2_217410559_G_A_dose | 2.182*** (1.833, 2.531) | 2.100** (1.576, 2.625) | 2.244*** (1.776, 2.712) |
| bmi5 | 1.159*** (1.143, 1.175) | 1.155*** (1.132, 1.179) | 1.161*** (1.139, 1.183) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.110*** (1.078, 1.141) | 1.165*** (1.116, 1.214) | 1.074*** (1.033, 1.115) |
| chr2_217410559_G_A_dose:bmi5 | 0.859*** (0.796, 0.922) | 0.866** (0.771, 0.961) | 0.854*** (0.770, 0.938) |
| Constant | 1.247 (0.844, 1.650) | 1.394 (0.952, 1.835) | 0.301*** (0.106, 0.497) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 2.1518e-06 | |||
| GxE term LRtest p = 2.7869e-03 | |||
| GxE term LRtest p = 2.4341e-04 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr2_217410559_G_A_dose | 2.182*** (1.833, 2.531) | 3.340*** (2.779, 3.901) | 1.473 (0.941, 2.005) | 2.480** (1.875, 3.086) |
| bmi5 | 1.159*** (1.143, 1.175) | 1.219*** (1.194, 1.244) | 1.158*** (1.134, 1.182) | 1.106*** (1.079, 1.133) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.019*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.110*** (1.078, 1.141) | 1.059* (1.009, 1.109) | 0.843*** (0.795, 0.892) | 1.300*** (1.249, 1.351) |
| chr2_217410559_G_A_dose:bmi5 | 0.859*** (0.796, 0.922) | 0.793*** (0.691, 0.895) | 0.920 (0.825, 1.015) | 0.839** (0.729, 0.950) |
| Constant | 1.247 (0.844, 1.650) | 0.408*** (-0.117, 0.934) | 0.191*** (-0.326, 0.708) | 1.710* (1.247, 2.173) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 2.1518e-06 | ||||
| GxE term LRtest p = 4.7942e-06 | ||||
| GxE term LRtest p = 8.4947e-02 | ||||
| GxE term LRtest p = 1.5612e-03 | ||||
Stratified OR
| GG | GA | AA | GA | AA | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.09 (0.98-1.21) | 1.1 (0.51-2.35) | 1.09 (0.98-1.21) | 1.1 (0.51-2.35) | 11113.9/16250.3 | 741.7/977.2 | 14.4/17.5 |
| p0 | P= 1 | P= 0.1 | P= 0.81 | P= 0.1 | P= 0.81 | |||
| bmic3f=Overweight | 1.13 (1.09-1.17) | 1.08 (0.98-1.19) | 0.75 (0.37-1.52) | 0.96 (0.87-1.05) | 0.66 (0.32-1.35) | 14534.9/19428.4 | 909.1/1230.2 | 14/20.4 |
| p1 | P= 3.5e-12 | P= 0.11 | P= 0.42 | P= 0.37 | P= 0.25 | |||
| bmic3f=Obese | 1.4 (1.34-1.46) | 1.11 (0.98-1.26) | 0.73 (0.29-1.81) | 0.8 (0.7-0.9) | 0.52 (0.21-1.29) | 8568.4/9829.8 | 510.5/682.8 | 8.1/14.4 |
| p2 | P= 1.7e-59 | P= 0.098 | P= 0.49 | P= 0.00044 | P= 0.16 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.13 (1.09-1.17) | 0.99 (0.86-1.14) | 0.68 (0.24-1.92) | |||||
| p1 (G) | P= 3.5e-12 | P= 0.89 | P= 0.47 | |||||
| bmic3f=Obese(G) | 1.4 (1.34-1.46) | 1.02 (0.87-1.2) | 0.66 (0.2-2.16) | |||||
| p2 (G) | P= 1.7e-59 | P= 0.83 | P= 0.49 | |||||
Stratified OR (adj smk_ever)
| GG | GA | AA | GA | AA | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.1 (0.99-1.22) | 1.13 (0.53-2.41) | 1.1 (0.99-1.22) | 1.13 (0.53-2.41) | 10833.5/16034.6 | 726.1/963.9 | 14.4/17.5 |
| p0 | P= 1 | P= 0.082 | P= 0.76 | P= 0.082 | P= 0.76 | |||
| bmic3f=Overweight | 1.14 (1.1-1.18) | 1.09 (0.99-1.2) | 0.77 (0.37-1.58) | 0.96 (0.87-1.05) | 0.67 (0.33-1.38) | 14170/19123.5 | 889/1214.1 | 14/19.4 |
| p1 | P= 4e-13 | P= 0.092 | P= 0.47 | P= 0.35 | P= 0.28 | |||
| bmic3f=Obese | 1.41 (1.36-1.47) | 1.11 (0.98-1.26) | 0.85 (0.34-2.15) | 0.79 (0.69-0.9) | 0.6 (0.24-1.52) | 8382.7/9680.9 | 494.2/671.7 | 8.1/13.4 |
| p2 | P= 8.2e-62 | P= 0.11 | P= 0.73 | P= 0.00028 | P= 0.28 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.14 (1.1-1.18) | 0.99 (0.86-1.14) | 0.68 (0.24-1.94) | |||||
| p1 (G) | P= 4e-13 | P= 0.87 | P= 0.47 | |||||
| bmic3f=Obese(G) | 1.41 (1.36-1.47) | 1.01 (0.86-1.19) | 0.76 (0.23-2.5) | |||||
| p2 (G) | P= 8.2e-62 | P= 0.9 | P= 0.65 | |||||
Locuszoom
Func Annot
chr3_100037644_A_G
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr3_100037644_A_G_dose | 1.376*** (1.241, 1.512) | 1.355*** (1.178, 1.532) | 1.409** (1.195, 1.623) |
| bmi5 | 1.188*** (1.167, 1.208) | 1.146*** (1.119, 1.173) | 1.257*** (1.224, 1.289) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.003, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.110*** (1.079, 1.142) | ||
| chr3_100037644_A_G_dose:bmi5 | 0.942*** (0.917, 0.966) | 0.945*** (0.913, 0.977) | 0.937*** (0.898, 0.975) |
| Constant | 1.097 (0.687, 1.506) | 0.360*** (0.119, 0.601) | 0.818 (0.375, 1.260) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 1.5427e-06 | |||
| GxE term LRtest p = 5.9801e-04 | |||
| GxE term LRtest p = 8.6449e-04 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr3_100037644_A_G_dose | 1.376*** (1.241, 1.512) | 1.314** (1.117, 1.511) | 1.439*** (1.251, 1.627) |
| bmi5 | 1.188*** (1.167, 1.208) | 1.182*** (1.152, 1.213) | 1.191*** (1.163, 1.220) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.110*** (1.079, 1.142) | 1.165*** (1.116, 1.214) | 1.074*** (1.033, 1.115) |
| chr3_100037644_A_G_dose:bmi5 | 0.942*** (0.917, 0.966) | 0.946** (0.910, 0.982) | 0.937*** (0.904, 0.971) |
| Constant | 1.097 (0.687, 1.506) | 1.256 (0.801, 1.711) | 0.259*** (0.038, 0.479) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 1.5427e-06 | |||
| GxE term LRtest p = 2.2744e-03 | |||
| GxE term LRtest p = 1.8727e-04 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr3_100037644_A_G_dose | 1.376*** (1.241, 1.512) | 1.361** (1.146, 1.576) | 1.339** (1.134, 1.544) | 1.433** (1.203, 1.663) |
| bmi5 | 1.188*** (1.167, 1.208) | 1.243*** (1.211, 1.275) | 1.187*** (1.155, 1.218) | 1.137*** (1.102, 1.172) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.019*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.110*** (1.079, 1.142) | 1.060* (1.011, 1.110) | 0.844*** (0.795, 0.892) | 1.301*** (1.250, 1.352) |
| chr3_100037644_A_G_dose:bmi5 | 0.942*** (0.917, 0.966) | 0.941** (0.902, 0.979) | 0.948** (0.911, 0.985) | 0.934** (0.892, 0.975) |
| Constant | 1.097 (0.687, 1.506) | 0.375*** (-0.163, 0.913) | 0.166*** (-0.363, 0.696) | 1.485 (1.006, 1.965) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 1.5427e-06 | ||||
| GxE term LRtest p = 1.8201e-03 | ||||
| GxE term LRtest p = 4.6890e-03 | ||||
| GxE term LRtest p = 1.2279e-03 | ||||
Stratified OR
| AA | AG | GG | AG | GG | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.03 (0.98-1.09) | 1.19 (1.08-1.31) | 1.03 (0.98-1.09) | 1.19 (1.08-1.31) | 6172.5/9201.1 | 4726.8/6798.9 | 970.7/1244.9 |
| p0 | P= 1 | P= 0.21 | P= 0.00042 | P= 0.21 | P= 0.00042 | |||
| bmic3f=Overweight | 1.17 (1.11-1.22) | 1.14 (1.08-1.2) | 1.11 (1.02-1.22) | 0.98 (0.93-1.03) | 0.95 (0.87-1.04) | 8120.4/10805.7 | 6168.1/8276.2 | 1169.5/1597.1 |
| p1 | P= 9.4e-11 | P= 2.2e-07 | P= 0.019 | P= 0.36 | P= 0.29 | |||
| bmic3f=Obese | 1.49 (1.41-1.57) | 1.33 (1.26-1.41) | 1.29 (1.15-1.45) | 0.9 (0.84-0.96) | 0.87 (0.77-0.98) | 4880.3/5388.9 | 3512.7/4284.4 | 694/853.6 |
| p2 | P= 1.3e-46 | P= 3.5e-21 | P= 1.2e-05 | P= 0.00088 | P= 0.019 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.17 (1.11-1.22) | 1.1 (1.04-1.16) | 0.93 (0.83-1.06) | |||||
| p1 (G) | P= 9.4e-11 | P= 0.00037 | P= 0.27 | |||||
| bmic3f=Obese(G) | 1.49 (1.41-1.57) | 1.29 (1.21-1.37) | 1.09 (0.94-1.25) | |||||
| p2 (G) | P= 1.3e-46 | P= 3e-15 | P= 0.26 | |||||
Stratified OR (adj smk_ever)
| AA | AG | GG | AG | GG | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.03 (0.98-1.09) | 1.19 (1.08-1.31) | 1.03 (0.98-1.09) | 1.19 (1.08-1.31) | 6031.6/9083.1 | 4594/6702.3 | 948.4/1230.6 |
| p0 | P= 1 | P= 0.29 | P= 0.00064 | P= 0.29 | P= 0.00064 | |||
| bmic3f=Overweight | 1.17 (1.12-1.23) | 1.14 (1.09-1.2) | 1.12 (1.03-1.23) | 0.98 (0.93-1.02) | 0.96 (0.88-1.05) | 7926.7/10643.2 | 6004.2/8143.5 | 1142.1/1570.2 |
| p1 | P= 4.2e-11 | P= 1.9e-07 | P= 0.011 | P= 0.32 | P= 0.37 | |||
| bmic3f=Obese | 1.49 (1.41-1.58) | 1.35 (1.27-1.43) | 1.3 (1.16-1.46) | 0.9 (0.84-0.96) | 0.87 (0.77-0.98) | 4769.8/5313.3 | 3435.2/4212.8 | 680/839.9 |
| p2 | P= 8.4e-47 | P= 3.3e-22 | P= 8e-06 | P= 0.0018 | P= 0.022 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.17 (1.12-1.23) | 1.11 (1.05-1.17) | 0.95 (0.84-1.07) | |||||
| p1 (G) | P= 4.2e-11 | P= 0.00016 | P= 0.4 | |||||
| bmic3f=Obese(G) | 1.49 (1.41-1.58) | 1.31 (1.23-1.39) | 1.1 (0.95-1.27) | |||||
| p2 (G) | P= 8.4e-47 | P= 1.4e-16 | P= 0.2 | |||||
Locuszoom
Func Annot
chr6_138766021_C_T
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr6_138766021_C_T_dose | 0.537*** (0.276, 0.798) | 0.616** (0.277, 0.954) | 0.453*** (0.040, 0.866) |
| bmi5 | 1.131*** (1.115, 1.148) | 1.098*** (1.076, 1.119) | 1.189*** (1.162, 1.215) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.004, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.111*** (1.079, 1.142) | ||
| chr6_138766021_C_T_dose:bmi5 | 1.120*** (1.073, 1.167) | 1.095** (1.034, 1.157) | 1.153*** (1.079, 1.228) |
| Constant | 1.415 (1.012, 1.819) | 0.454*** (0.231, 0.678) | 1.095 (0.667, 1.524) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 2.1947e-06 | |||
| GxE term LRtest p = 3.5392e-03 | |||
| GxE term LRtest p = 1.5879e-04 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr6_138766021_C_T_dose | 0.537*** (0.276, 0.798) | 0.628* (0.248, 1.008) | 0.468*** (0.108, 0.828) |
| bmi5 | 1.131*** (1.115, 1.148) | 1.132*** (1.108, 1.157) | 1.129*** (1.106, 1.152) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.111*** (1.079, 1.142) | 1.166*** (1.117, 1.215) | 1.075*** (1.034, 1.115) |
| chr6_138766021_C_T_dose:bmi5 | 1.120*** (1.073, 1.167) | 1.097** (1.028, 1.166) | 1.141*** (1.076, 1.206) |
| Constant | 1.415 (1.012, 1.819) | 1.538 (1.096, 1.980) | 0.351*** (0.152, 0.550) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 2.1947e-06 | |||
| GxE term LRtest p = 8.2124e-03 | |||
| GxE term LRtest p = 5.8576e-05 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr6_138766021_C_T_dose | 0.537*** (0.276, 0.798) | 0.419*** (0.009, 0.828) | 0.630* (0.242, 1.017) | 0.466*** (0.031, 0.901) |
| bmi5 | 1.131*** (1.115, 1.148) | 1.178*** (1.152, 1.204) | 1.139*** (1.114, 1.164) | 1.073*** (1.045, 1.102) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.020*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.111*** (1.079, 1.142) | 1.061* (1.011, 1.111) | 0.844*** (0.795, 0.892) | 1.302*** (1.251, 1.353) |
| chr6_138766021_C_T_dose:bmi5 | 1.120*** (1.073, 1.167) | 1.163*** (1.091, 1.236) | 1.092* (1.022, 1.162) | 1.151*** (1.073, 1.229) |
| Constant | 1.415 (1.012, 1.819) | 0.496** (-0.031, 1.023) | 0.207*** (-0.311, 0.725) | 1.996** (1.531, 2.461) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 2.1947e-06 | ||||
| GxE term LRtest p = 4.5510e-05 | ||||
| GxE term LRtest p = 1.4042e-02 | ||||
| GxE term LRtest p = 4.5596e-04 | ||||
Stratified OR
| CC | CT | TT | CT | TT | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 0.91 (0.84-0.99) | 0.7 (0.46-1.08) | 0.91 (0.84-0.99) | 0.7 (0.46-1.08) | 10452.8/15081.3 | 1372/2079.8 | 45.2/83.8 |
| p0 | P= 1 | P= 0.024 | P= 0.1 | P= 0.024 | P= 0.1 | |||
| bmic3f=Overweight | 1.11 (1.07-1.15) | 1.1 (1.02-1.18) | 1.02 (0.69-1.48) | 0.99 (0.92-1.06) | 0.92 (0.63-1.34) | 13552.5/18192.6 | 1841.3/2395 | 64.1/91.4 |
| p1 | P= 1.9e-08 | P= 0.014 | P= 0.94 | P= 0.75 | P= 0.65 | |||
| bmic3f=Obese | 1.32 (1.27-1.38) | 1.56 (1.41-1.71) | 2.33 (1.34-4.05) | 1.17 (1.06-1.3) | 1.76 (1.01-3.06) | 7897.4/9352.7 | 1143.3/1143.4 | 46.4/30.9 |
| p2 | P= 2.3e-39 | P= 3.5e-19 | P= 0.0026 | P= 0.0016 | P= 0.045 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.11 (1.07-1.15) | 1.2 (1.09-1.33) | 1.45 (0.82-2.56) | |||||
| p1 (G) | P= 1.9e-08 | P= 0.00037 | P= 0.2 | |||||
| bmic3f=Obese(G) | 1.32 (1.27-1.38) | 1.71 (1.51-1.93) | 3.32 (1.66-6.67) | |||||
| p2 (G) | P= 2.3e-39 | P= 2.2e-18 | P= 0.00072 | |||||
Stratified OR (adj smk_ever)
| CC | CT | TT | CT | TT | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 0.91 (0.84-0.99) | 0.7 (0.45-1.07) | 0.91 (0.84-0.99) | 0.7 (0.45-1.07) | 10188.6/14885.9 | 1340.3/2046.3 | 45.1/83.8 |
| p0 | P= 1 | P= 0.033 | P= 0.099 | P= 0.033 | P= 0.099 | |||
| bmic3f=Overweight | 1.11 (1.08-1.16) | 1.11 (1.03-1.2) | 1.03 (0.7-1.51) | 1 (0.93-1.07) | 0.92 (0.63-1.36) | 13206.7/17914.7 | 1804.3/2353 | 62/89.3 |
| p1 | P= 4.6e-09 | P= 0.0052 | P= 0.89 | P= 0.93 | P= 0.68 | |||
| bmic3f=Obese | 1.34 (1.28-1.4) | 1.58 (1.43-1.74) | 2.31 (1.33-4.02) | 1.18 (1.06-1.3) | 1.73 (0.99-3.01) | 7724/9214 | 1115.5/1121.3 | 45.5/30.7 |
| p2 | P= 3.7e-41 | P= 8.6e-20 | P= 0.003 | P= 0.0015 | P= 0.053 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.11 (1.08-1.16) | 1.22 (1.1-1.35) | 1.47 (0.83-2.62) | |||||
| p1 (G) | P= 4.6e-09 | P= 0.00021 | P= 0.19 | |||||
| bmic3f=Obese(G) | 1.34 (1.28-1.4) | 1.72 (1.53-1.95) | 3.32 (1.65-6.67) | |||||
| p2 (G) | P= 3.7e-41 | P= 1.5e-18 | P= 0.00077 | |||||
Locuszoom
Func Annot
chr9_136601110_C_G
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr9_136601110_C_G_dose | 0.530*** (0.268, 0.792) | 0.561*** (0.224, 0.898) | 0.468*** (0.049, 0.887) |
| bmi5 | 1.130*** (1.113, 1.147) | 1.094*** (1.072, 1.116) | 1.189*** (1.163, 1.216) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.003, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.110*** (1.079, 1.141) | ||
| chr9_136601110_C_G_dose:bmi5 | 1.118*** (1.071, 1.166) | 1.110*** (1.049, 1.171) | 1.141*** (1.065, 1.216) |
| Constant | 1.433 (1.030, 1.837) | 0.466*** (0.241, 0.690) | 1.093 (0.665, 1.522) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 3.4901e-06 | |||
| GxE term LRtest p = 8.2985e-04 | |||
| GxE term LRtest p = 6.1030e-04 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr9_136601110_C_G_dose | 0.530*** (0.268, 0.792) | 0.538** (0.159, 0.917) | 0.521*** (0.156, 0.885) |
| bmi5 | 1.130*** (1.113, 1.147) | 1.130*** (1.105, 1.154) | 1.129*** (1.105, 1.152) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.110*** (1.079, 1.141) | 1.165*** (1.116, 1.214) | 1.074*** (1.033, 1.115) |
| chr9_136601110_C_G_dose:bmi5 | 1.118*** (1.071, 1.166) | 1.109** (1.040, 1.177) | 1.128*** (1.062, 1.194) |
| Constant | 1.433 (1.030, 1.837) | 1.590* (1.147, 2.033) | 0.349*** (0.149, 0.549) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 3.4901e-06 | |||
| GxE term LRtest p = 3.1123e-03 | |||
| GxE term LRtest p = 3.2050e-04 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr9_136601110_C_G_dose | 0.530*** (0.268, 0.792) | 0.505*** (0.098, 0.912) | 0.511*** (0.117, 0.905) | 0.719 (0.276, 1.162) |
| bmi5 | 1.130*** (1.113, 1.147) | 1.180*** (1.153, 1.206) | 1.133*** (1.107, 1.158) | 1.084*** (1.056, 1.113) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.020*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.110*** (1.079, 1.141) | 1.060* (1.010, 1.110) | 0.844*** (0.795, 0.892) | 1.300*** (1.249, 1.351) |
| chr9_136601110_C_G_dose:bmi5 | 1.118*** (1.071, 1.166) | 1.131*** (1.059, 1.204) | 1.125** (1.054, 1.196) | 1.063 (0.983, 1.144) |
| Constant | 1.433 (1.030, 1.837) | 0.488** (-0.040, 1.016) | 0.216*** (-0.303, 0.735) | 1.899** (1.434, 2.365) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 3.4901e-06 | ||||
| GxE term LRtest p = 8.8246e-04 | ||||
| GxE term LRtest p = 1.1910e-03 | ||||
| GxE term LRtest p = 1.3749e-01 | ||||
Stratified OR
| CC | CG | GG | CG | GG | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 0.86 (0.79-0.94) | 0.62 (0.42-0.93) | 0.86 (0.79-0.94) | 0.62 (0.42-0.93) | 10340.4/14811.9 | 1474/2328.3 | 55.7/104.7 |
| p0 | P= 1 | P= 0.00045 | P= 0.022 | P= 0.00045 | P= 0.022 | |||
| bmic3f=Overweight | 1.1 (1.06-1.14) | 1.1 (1.02-1.18) | 1.01 (0.69-1.48) | 1 (0.93-1.08) | 0.92 (0.63-1.35) | 13350.1/17911.5 | 2035.3/2661.1 | 72.6/106.4 |
| p1 | P= 7.1e-07 | P= 0.011 | P= 0.96 | P= 0.95 | P= 0.67 | |||
| bmic3f=Obese | 1.31 (1.26-1.37) | 1.53 (1.38-1.68) | 1.46 (0.88-2.44) | 1.16 (1.05-1.28) | 1.11 (0.67-1.85) | 7802.8/9196 | 1233.7/1274.8 | 50.5/56.2 |
| p2 | P= 3.3e-36 | P= 1.4e-17 | P= 0.15 | P= 0.0038 | P= 0.68 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.1 (1.06-1.14) | 1.27 (1.15-1.41) | 1.61 (0.93-2.82) | |||||
| p1 (G) | P= 7.1e-07 | P= 3.3e-06 | P= 0.092 | |||||
| bmic3f=Obese(G) | 1.31 (1.26-1.37) | 1.77 (1.57-2) | 2.34 (1.22-4.48) | |||||
| p2 (G) | P= 3.3e-36 | P= 1.6e-20 | P= 0.01 | |||||
Stratified OR (adj smk_ever)
| CC | CG | GG | CG | GG | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 0.86 (0.8-0.94) | 0.62 (0.41-0.93) | 0.86 (0.8-0.94) | 0.62 (0.41-0.93) | 10084.6/14620.4 | 1435.3/2292.5 | 54.1/103.1 |
| p0 | P= 1 | P= 0.00063 | P= 0.022 | P= 0.00063 | P= 0.022 | |||
| bmic3f=Overweight | 1.1 (1.06-1.15) | 1.1 (1.03-1.19) | 1.01 (0.69-1.5) | 1 (0.93-1.08) | 0.92 (0.62-1.36) | 13015/17630 | 1986.9/2621.6 | 71.1/105.4 |
| p1 | P= 1.4e-07 | P= 0.0086 | P= 0.94 | P= 1 | P= 0.67 | |||
| bmic3f=Obese | 1.33 (1.27-1.38) | 1.55 (1.41-1.71) | 1.5 (0.9-2.5) | 1.17 (1.06-1.3) | 1.13 (0.68-1.88) | 7625.8/9058.9 | 1208.9/1250.9 | 50.3/56.1 |
| p2 | P= 1.3e-37 | P= 1.4e-18 | P= 0.12 | P= 0.0023 | P= 0.64 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.1 (1.06-1.15) | 1.28 (1.15-1.42) | 1.63 (0.93-2.87) | |||||
| p1 (G) | P= 1.4e-07 | P= 3.4e-06 | P= 0.088 | |||||
| bmic3f=Obese(G) | 1.33 (1.27-1.38) | 1.8 (1.59-2.03) | 2.41 (1.25-4.63) | |||||
| p2 (G) | P= 1.3e-37 | P= 3.7e-21 | P= 0.0084 | |||||
Locuszoom
Func Annot
Two-step findings
chr15_33120215_T_C
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr15_33120215_T_C_dose | 1.497*** (1.349, 1.646) | 1.509*** (1.317, 1.702) | 1.466** (1.231, 1.702) |
| bmi5 | 1.178*** (1.159, 1.197) | 1.138*** (1.114, 1.163) | 1.241*** (1.211, 1.272) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.003, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.110*** (1.078, 1.141) | ||
| chr15_33120215_T_C_dose:bmi5 | 0.940*** (0.913, 0.966) | 0.940*** (0.905, 0.975) | 0.942** (0.900, 0.985) |
| Constant | 1.117 (0.710, 1.524) | 0.361*** (0.128, 0.594) | 0.847 (0.411, 1.284) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 5.2723e-06 | |||
| GxE term LRtest p = 5.1191e-04 | |||
| GxE term LRtest p = 6.1458e-03 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr15_33120215_T_C_dose | 1.497*** (1.349, 1.646) | 1.574*** (1.359, 1.789) | 1.429*** (1.224, 1.634) |
| bmi5 | 1.178*** (1.159, 1.197) | 1.179*** (1.151, 1.207) | 1.175*** (1.149, 1.201) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.110*** (1.078, 1.141) | 1.165*** (1.116, 1.214) | 1.073*** (1.032, 1.114) |
| chr15_33120215_T_C_dose:bmi5 | 0.940*** (0.913, 0.966) | 0.933*** (0.894, 0.972) | 0.946** (0.909, 0.983) |
| Constant | 1.117 (0.710, 1.524) | 1.219 (0.770, 1.668) | 0.274*** (0.063, 0.484) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 5.2723e-06 | |||
| GxE term LRtest p = 4.8718e-04 | |||
| GxE term LRtest p = 3.0959e-03 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr15_33120215_T_C_dose | 1.497*** (1.349, 1.646) | 1.570*** (1.337, 1.804) | 1.533*** (1.310, 1.756) | 1.521*** (1.273, 1.769) |
| bmi5 | 1.178*** (1.159, 1.197) | 1.238*** (1.209, 1.268) | 1.184*** (1.155, 1.212) | 1.122*** (1.090, 1.154) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.020*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.110*** (1.078, 1.141) | 1.059* (1.009, 1.109) | 0.843*** (0.794, 0.891) | 1.299*** (1.248, 1.350) |
| chr15_33120215_T_C_dose:bmi5 | 0.940*** (0.913, 0.966) | 0.928*** (0.886, 0.970) | 0.935** (0.894, 0.975) | 0.940** (0.895, 0.985) |
| Constant | 1.117 (0.710, 1.524) | 0.368*** (-0.166, 0.901) | 0.165*** (-0.359, 0.690) | 1.544 (1.072, 2.017) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 5.2723e-06 | ||||
| GxE term LRtest p = 4.2147e-04 | ||||
| GxE term LRtest p = 9.8524e-04 | ||||
| GxE term LRtest p = 6.8539e-03 | ||||
Stratified OR
| TT | TC | CC | TC | CC | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.12 (1.06-1.18) | 1.26 (1.12-1.43) | 1.12 (1.06-1.18) | 1.26 (1.12-1.43) | 7377.6/11093.1 | 3945.3/5466.8 | 547.1/685.2 |
| p0 | P= 1 | P= 4.5e-05 | P= 0.00017 | P= 4.5e-05 | P= 0.00017 | |||
| bmic3f=Overweight | 1.13 (1.09-1.18) | 1.24 (1.18-1.31) | 1.28 (1.14-1.43) | 1.1 (1.05-1.15) | 1.13 (1.01-1.26) | 9679.6/13323.4 | 5112.1/6527.7 | 666.4/827.9 |
| p1 | P= 5.7e-09 | P= 7.8e-18 | P= 1.7e-05 | P= 9.7e-05 | P= 0.031 | |||
| bmic3f=Obese | 1.45 (1.38-1.52) | 1.42 (1.34-1.51) | 1.27 (1.09-1.47) | 0.98 (0.92-1.05) | 0.87 (0.75-1.02) | 5818.6/6629.1 | 2916.2/3432.6 | 352.2/465.3 |
| p2 | P= 1.9e-50 | P= 7.2e-30 | P= 0.0019 | P= 0.57 | P= 0.079 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.13 (1.09-1.18) | 1.11 (1.05-1.18) | 1.01 (0.86-1.19) | |||||
| p1 (G) | P= 5.7e-09 | P= 0.00026 | P= 0.88 | |||||
| bmic3f=Obese(G) | 1.45 (1.38-1.52) | 1.28 (1.19-1.37) | 1 (0.83-1.21) | |||||
| p2 (G) | P= 1.9e-50 | P= 2.3e-12 | P= 0.98 | |||||
Stratified OR (adj smk_ever)
| TT | TC | CC | TC | CC | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.11 (1.06-1.17) | 1.28 (1.13-1.45) | 1.11 (1.06-1.17) | 1.28 (1.13-1.45) | 7192.5/10942.2 | 3840.6/5398.7 | 541/675.2 |
| p0 | P= 1 | P= 8.5e-05 | P= 7.7e-05 | P= 8.5e-05 | P= 7.7e-05 | |||
| bmic3f=Overweight | 1.14 (1.09-1.19) | 1.25 (1.19-1.31) | 1.28 (1.15-1.44) | 1.1 (1.04-1.15) | 1.13 (1.01-1.26) | 9441.7/13108.8 | 4986/6435.1 | 645.4/813.1 |
| p1 | P= 1.2e-09 | P= 4.1e-18 | P= 1.7e-05 | P= 0.00018 | P= 0.039 | |||
| bmic3f=Obese | 1.46 (1.39-1.54) | 1.44 (1.35-1.53) | 1.29 (1.11-1.5) | 0.99 (0.92-1.05) | 0.88 (0.76-1.03) | 5685.6/6537 | 2854.2/3372.6 | 345.2/456.3 |
| p2 | P= 2.1e-51 | P= 4.6e-31 | P= 0.00096 | P= 0.65 | P= 0.11 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.14 (1.09-1.19) | 1.12 (1.06-1.19) | 1 (0.85-1.18) | |||||
| p1 (G) | P= 1.2e-09 | P= 0.00012 | P= 0.99 | |||||
| bmic3f=Obese(G) | 1.46 (1.39-1.54) | 1.29 (1.21-1.39) | 1.01 (0.83-1.22) | |||||
| p2 (G) | P= 2.1e-51 | P= 2.1e-13 | P= 0.95 | |||||
Locuszoom
Func Annot
chr15_33122966_C_T
Allele freq
GxE model by sex
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Female (Ca=17139,Co=23717) | Male (Ca=19276,Co=24734) | |
| (1) | (2) | (3) | |
| chr15_33122966_C_T_dose | 1.501*** (1.352, 1.649) | 1.521*** (1.329, 1.713) | 1.456** (1.220, 1.691) |
| bmi5 | 1.178*** (1.159, 1.197) | 1.139*** (1.114, 1.164) | 1.240*** (1.210, 1.271) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.006*** (1.003, 1.008) | 1.009*** (1.007, 1.011) |
| sex | 1.110*** (1.078, 1.141) | ||
| chr15_33122966_C_T_dose:bmi5 | 0.939*** (0.913, 0.966) | 0.939*** (0.904, 0.974) | 0.944** (0.902, 0.987) |
| Constant | 1.116 (0.709, 1.523) | 0.360*** (0.127, 0.593) | 0.850 (0.414, 1.287) |
| Observations | 84,866 | 40,856 | 44,010 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 4.9681e-06 | |||
| GxE term LRtest p = 3.7163e-04 | |||
| GxE term LRtest p = 7.9671e-03 | |||
GxE model by study design
| Dependent variable: | |||
| outcome | |||
| All (Ca=36415,Co=48451) | Cohort (Ca=15858,Co=28688) | Case-Control (Ca=20557,Co=19763) | |
| (1) | (2) | (3) | |
| chr15_33122966_C_T_dose | 1.501*** (1.352, 1.649) | 1.584*** (1.369, 1.799) | 1.427*** (1.222, 1.632) |
| bmi5 | 1.178*** (1.159, 1.197) | 1.180*** (1.152, 1.208) | 1.175*** (1.149, 1.201) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 1.005*** (1.002, 1.008) | 1.008*** (1.006, 1.010) |
| sex | 1.110*** (1.078, 1.141) | 1.165*** (1.116, 1.214) | 1.073*** (1.032, 1.114) |
| chr15_33122966_C_T_dose:bmi5 | 0.939*** (0.913, 0.966) | 0.932*** (0.893, 0.971) | 0.946** (0.909, 0.983) |
| Constant | 1.116 (0.709, 1.523) | 1.215 (0.766, 1.665) | 0.274*** (0.064, 0.484) |
| Observations | 84,866 | 44,546 | 40,320 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| GxE term LRtest p = 4.9681e-06 | |||
| GxE term LRtest p = 4.0843e-04 | |||
| GxE term LRtest p = 3.3760e-03 | |||
GxE model by tumor site
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=36415,Co=48451) | Proximal (Ca=9398,Co=48451) | Distal (Ca=10928,Co=48451) | Rectal (Ca=9200,Co=48451) | |
| (1) | (2) | (3) | (4) | |
| chr15_33122966_C_T_dose | 1.501*** (1.352, 1.649) | 1.548*** (1.315, 1.782) | 1.528*** (1.304, 1.751) | 1.562*** (1.314, 1.810) |
| bmi5 | 1.178*** (1.159, 1.197) | 1.237*** (1.207, 1.266) | 1.183*** (1.155, 1.212) | 1.124*** (1.092, 1.156) |
| age_ref_imp | 1.007*** (1.006, 1.009) | 0.997* (0.995, 1.000) | 1.020*** (1.017, 1.022) | 0.992*** (0.989, 0.994) |
| sex | 1.110*** (1.078, 1.141) | 1.059* (1.009, 1.109) | 0.843*** (0.794, 0.891) | 1.299*** (1.248, 1.350) |
| chr15_33122966_C_T_dose:bmi5 | 0.939*** (0.913, 0.966) | 0.931*** (0.889, 0.973) | 0.935** (0.895, 0.975) | 0.936** (0.891, 0.981) |
| Constant | 1.116 (0.709, 1.523) | 0.370*** (-0.164, 0.903) | 0.165*** (-0.359, 0.690) | 1.528 (1.056, 2.001) |
| Observations | 84,866 | 57,849 | 59,379 | 57,651 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| GxE term LRtest p = 4.9681e-06 | ||||
| GxE term LRtest p = 7.3858e-04 | ||||
| GxE term LRtest p = 1.0582e-03 | ||||
| GxE term LRtest p = 3.8049e-03 | ||||
Stratified OR
| CC | CT | TT | CT | TT | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.12 (1.06-1.18) | 1.26 (1.12-1.43) | 1.12 (1.06-1.18) | 1.26 (1.12-1.43) | 7382/11094.8 | 3938.6/5459 | 549.5/691.3 |
| p0 | P= 1 | P= 4.3e-05 | P= 0.0002 | P= 4.3e-05 | P= 0.0002 | |||
| bmic3f=Overweight | 1.13 (1.08-1.18) | 1.25 (1.19-1.31) | 1.28 (1.14-1.43) | 1.1 (1.05-1.16) | 1.13 (1.01-1.27) | 9678.1/13327.5 | 5114.5/6524.9 | 665.5/826.6 |
| p1 | P= 7.7e-09 | P= 4e-18 | P= 1.7e-05 | P= 5.8e-05 | P= 0.029 | |||
| bmic3f=Obese | 1.45 (1.38-1.52) | 1.43 (1.34-1.52) | 1.26 (1.09-1.47) | 0.99 (0.92-1.05) | 0.87 (0.75-1.02) | 5812.3/6625.6 | 2924.4/3436.3 | 350.2/465.1 |
| p2 | P= 3.9e-50 | P= 2.9e-30 | P= 0.0022 | P= 0.65 | P= 0.077 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.13 (1.08-1.18) | 1.12 (1.05-1.18) | 1.02 (0.86-1.19) | |||||
| p1 (G) | P= 7.7e-09 | P= 0.00021 | P= 0.85 | |||||
| bmic3f=Obese(G) | 1.45 (1.38-1.52) | 1.28 (1.19-1.37) | 1 (0.83-1.21) | |||||
| p2 (G) | P= 3.9e-50 | P= 1.5e-12 | P= 0.98 | |||||
Stratified OR (adj smk_ever)
| CC | CT | TT | CT | TT | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| bmic3f=Normal | 1 | 1.11 (1.06-1.18) | 1.28 (1.13-1.45) | 1.11 (1.06-1.18) | 1.28 (1.13-1.45) | 7196.4/10942.9 | 3834.3/5391.8 | 543.3/681.3 |
| p0 | P= 1 | P= 8.5e-05 | P= 8.9e-05 | P= 8.5e-05 | P= 8.9e-05 | |||
| bmic3f=Overweight | 1.14 (1.09-1.19) | 1.25 (1.19-1.32) | 1.28 (1.15-1.44) | 1.1 (1.05-1.15) | 1.13 (1.01-1.26) | 9441.2/13112.5 | 4987.3/6432.6 | 644.5/811.9 |
| p1 | P= 1.5e-09 | P= 2.4e-18 | P= 1.7e-05 | P= 0.00012 | P= 0.038 | |||
| bmic3f=Obese | 1.46 (1.39-1.54) | 1.44 (1.36-1.54) | 1.29 (1.11-1.5) | 0.99 (0.93-1.05) | 0.88 (0.76-1.03) | 5680.3/6533.6 | 2860.4/3376.3 | 344.2/456.1 |
| p2 | P= 4.2e-51 | P= 2.4e-31 | P= 0.00098 | P= 0.72 | P= 0.11 | |||
| E param by G | ||||||||
| bmic3f=Overweight(G) | 1.14 (1.09-1.19) | 1.12 (1.06-1.19) | 1 (0.85-1.18) | |||||
| p1 (G) | P= 1.5e-09 | P= 9.6e-05 | P= 0.96 | |||||
| bmic3f=Obese(G) | 1.46 (1.39-1.54) | 1.3 (1.21-1.39) | 1.01 (0.83-1.22) | |||||
| p2 (G) | P= 4.2e-51 | P= 1.5e-13 | P= 0.93 | |||||
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3DF findings
All SNPs associated with BMI, no evidence of GxE (pvalue > 0.05), very small evidence of main effects
chr1_177889480_A_G
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chr12_50204089_G_A
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chr16_28649651_C_A
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chr16_53800954_T_C
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chr18_57850583_C_A
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chr18_57971625_A_G
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chr18_58083923_A_C
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chr19_47581242_C_T
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chr2_417167_T_C
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chr2_558080_G_T
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chr2_651365_G_A
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chr4_45181334_A_T
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