Description
Follow-up analyses of GWIS findings
- Table of significant and suggestive (1df GxE only)
bmi5 GWIS findings
- GxE models stratified by study_design and tumor site (proximal, distal, rectal)
- GxE models with additional covariate sets (might do this for aspirin ..)
- Odds ratios stratified by exposure and genotype
- Plots of model predicted outcome by 1 unit increase of exposure/allelic dosage
- Locuszoom plot
- Functional annotation plot
Suggestive GxE findings
chr11_120531547_C_G
Allele freq

GxE model by sex
sex stratified chr11_120531547_C_G_dose x bmi5
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Dependent variable:
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|
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outcome
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|
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All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
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|
|
(1)
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(2)
|
(3)
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chr11_120531547_C_G_dose
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0.726*** (0.597, 0.854)
|
0.726*** (0.558, 0.893)
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0.710*** (0.508, 0.912)
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bmi5
|
1.068*** (1.035, 1.101)
|
1.026 (0.983, 1.069)
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1.129*** (1.077, 1.181)
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|
age_ref_imp
|
1.007*** (1.006, 1.009)
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1.006*** (1.003, 1.008)
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1.009*** (1.007, 1.011)
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sex
|
1.110*** (1.079, 1.141)
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|
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chr11_120531547_C_G_dose:bmi5
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1.058*** (1.035, 1.082)
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1.064*** (1.034, 1.095)
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1.057** (1.021, 1.094)
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Constant
|
1.963** (1.529, 2.396)
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0.643** (0.338, 0.947)
|
1.519 (1.024, 2.014)
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|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
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|
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GxE term LRtest p = 1.6055e-06
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GxE term LRtest p = 5.5872e-05
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GxE term LRtest p = 2.6517e-03
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GxE model by study design
study_design stratified chr11_120531547_C_G_dose x bmi5
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Dependent variable:
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outcome
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|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
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Case-Control (Ca=20557,Co=19763)
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(1)
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(2)
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(3)
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chr11_120531547_C_G_dose
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0.726*** (0.597, 0.854)
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0.735** (0.548, 0.921)
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0.717*** (0.539, 0.894)
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bmi5
|
1.068*** (1.035, 1.101)
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1.067** (1.018, 1.116)
|
1.068** (1.023, 1.114)
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age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
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1.008*** (1.006, 1.010)
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sex
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1.110*** (1.079, 1.141)
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1.165*** (1.116, 1.214)
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1.074*** (1.033, 1.114)
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chr11_120531547_C_G_dose:bmi5
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1.058*** (1.035, 1.082)
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1.057** (1.024, 1.091)
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1.060*** (1.028, 1.092)
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Constant
|
1.963** (1.529, 2.396)
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2.160** (1.661, 2.658)
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0.482*** (0.187, 0.777)
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Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
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p<0.05; p<0.01; p<0.001
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|
|
(PC and Study estimates omitted from table)
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|
GxE term LRtest p = 1.6055e-06
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GxE term LRtest p = 1.2021e-03
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GxE term LRtest p = 3.8706e-04
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GxE model by tumor site
cancer_site_sum2 stratified chr11_120531547_C_G_dose x bmi5
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Dependent variable:
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|
|
|
|
|
outcome
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|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
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Distal (Ca=10928,Co=48451)
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Rectal (Ca=9200,Co=48451)
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|
|
(1)
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(2)
|
(3)
|
(4)
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|
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chr11_120531547_C_G_dose
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0.726*** (0.597, 0.854)
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0.745** (0.543, 0.947)
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0.804* (0.610, 0.999)
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0.712** (0.496, 0.929)
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bmi5
|
1.068*** (1.035, 1.101)
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1.129*** (1.077, 1.181)
|
1.093*** (1.042, 1.143)
|
1.011 (0.954, 1.068)
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age_ref_imp
|
1.007*** (1.006, 1.009)
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0.997* (0.995, 1.000)
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1.020*** (1.017, 1.022)
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0.992*** (0.989, 0.994)
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sex
|
1.110*** (1.079, 1.141)
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1.060* (1.010, 1.109)
|
0.843*** (0.795, 0.892)
|
1.301*** (1.250, 1.352)
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|
chr11_120531547_C_G_dose:bmi5
|
1.058*** (1.035, 1.082)
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1.050** (1.014, 1.086)
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1.042* (1.007, 1.077)
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1.064** (1.025, 1.103)
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Constant
|
1.963** (1.529, 2.396)
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0.637 (0.054, 1.219)
|
0.259*** (-0.311, 0.830)
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2.796*** (2.258, 3.333)
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|
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Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 1.6055e-06
|
|
|
GxE term LRtest p = 7.8067e-03
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|
|
GxE term LRtest p = 2.0831e-02
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|
|
GxE term LRtest p = 1.9867e-03
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Stratified OR
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|
G param by E
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Counts (Ca/Co)
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|
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CC
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CG
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GG
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CG
|
GG
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N0
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N1
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N2
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bmic3f=Normal
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1
|
0.98 (0.91-1.07)
|
0.9 (0.83-0.98)
|
0.98 (0.91-1.07)
|
0.9 (0.83-0.98)
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1652.3/2267.7
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5495.9/7743.9
|
4721.8/7233.4
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p0
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P= 1
|
P= 0.71
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P= 0.013
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P= 0.71
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P= 0.013
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bmic3f=Overweight
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1.08 (0.98-1.18)
|
1.08 (1-1.17)
|
1.05 (0.97-1.13)
|
1.01 (0.94-1.08)
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0.98 (0.91-1.05)
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2087.8/2748.9
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7202/9570.1
|
6168.2/8360
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p1
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P= 0.13
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P= 0.046
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P= 0.24
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P= 0.86
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P= 0.5
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bmic3f=Obese
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1.21 (1.09-1.36)
|
1.26 (1.16-1.37)
|
1.39 (1.28-1.51)
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1.04 (0.94-1.15)
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1.14 (1.04-1.26)
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1201.6/1461.8
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4099.9/4896.2
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3785.5/4169
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p2
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P= 0.00057
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P= 4.8e-08
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P= 3.5e-14
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P= 0.44
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P= 0.0069
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E param by G
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bmic3f=Overweight(G)
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1.08 (0.98-1.18)
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1.1 (1.04-1.16)
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1.16 (1.1-1.22)
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p1 (G)
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P= 0.13
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P= 0.00027
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P= 4.9e-08
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bmic3f=Obese(G)
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1.21 (1.09-1.36)
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1.28 (1.21-1.36)
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1.54 (1.44-1.64)
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p2 (G)
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P= 0.00057
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P= 3e-16
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P= 1.9e-41
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Stratified OR (adj smk_ever)
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G param by E
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Counts (Ca/Co)
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|
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CC
|
CG
|
GG
|
CG
|
GG
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N0
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N1
|
N2
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bmic3f=Normal
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1
|
0.99 (0.91-1.08)
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0.92 (0.84-0.99)
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0.99 (0.91-1.08)
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0.92 (0.84-0.99)
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1605.6/2244.1
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5352.5/7642.9
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4615.9/7129
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p0
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P= 1
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P= 0.82
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P= 0.033
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P= 0.82
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P= 0.033
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bmic3f=Overweight
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1.09 (1-1.2)
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1.1 (1.01-1.18)
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1.07 (0.98-1.15)
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1 (0.93-1.08)
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0.97 (0.9-1.05)
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2038.5/2700.5
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7011.7/9430.8
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6022.7/8225.7
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p1
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P= 0.063
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P= 0.024
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P= 0.12
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P= 0.99
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P= 0.47
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bmic3f=Obese
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1.24 (1.1-1.38)
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1.29 (1.19-1.4)
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1.41 (1.29-1.53)
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1.04 (0.95-1.15)
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1.14 (1.03-1.26)
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1171/1437.4
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4007.8/4813.2
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3706.2/4115.4
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p2
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P= 0.00021
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P= 3.8e-09
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P= 6.8e-15
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P= 0.39
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P= 0.0097
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E param by G
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bmic3f=Overweight(G)
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1.09 (1-1.2)
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1.11 (1.05-1.16)
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1.16 (1.1-1.23)
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p1 (G)
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P= 0.063
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P= 0.00013
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P= 3.6e-08
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bmic3f=Obese(G)
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1.24 (1.1-1.38)
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1.3 (1.23-1.38)
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1.54 (1.44-1.64)
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p2 (G)
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P= 0.00021
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P= 9.2e-18
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P= 1.2e-40
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Locuszoom

Func Annot

chr11_46574459_T_A
Allele freq

GxE model by sex
sex stratified chr11_46574459_T_A_dose x bmi5
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|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr11_46574459_T_A_dose
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0.509*** (0.218, 0.800)
|
0.466*** (0.084, 0.847)
|
0.596* (0.142, 1.049)
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|
bmi5
|
1.133*** (1.117, 1.150)
|
1.094*** (1.073, 1.115)
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1.199*** (1.173, 1.225)
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|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.006*** (1.004, 1.008)
|
1.009*** (1.007, 1.011)
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|
sex
|
1.111*** (1.079, 1.142)
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|
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chr11_46574459_T_A_dose:bmi5
|
1.136*** (1.083, 1.188)
|
1.159*** (1.090, 1.228)
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1.101* (1.019, 1.183)
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Constant
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1.403 (1.000, 1.806)
|
0.461*** (0.238, 0.683)
|
1.043 (0.616, 1.471)
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|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 1.9279e-06
|
|
|
GxE term LRtest p = 2.4866e-05
|
|
|
GxE term LRtest p = 2.1045e-02
|
GxE model by study design
study_design stratified chr11_46574459_T_A_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
|
Case-Control (Ca=20557,Co=19763)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr11_46574459_T_A_dose
|
0.509*** (0.218, 0.800)
|
0.559* (0.103, 1.015)
|
0.478*** (0.096, 0.860)
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|
bmi5
|
1.133*** (1.117, 1.150)
|
1.135*** (1.112, 1.159)
|
1.130*** (1.108, 1.153)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
|
1.008*** (1.006, 1.010)
|
|
sex
|
1.111*** (1.079, 1.142)
|
1.165*** (1.116, 1.214)
|
1.075*** (1.034, 1.116)
|
|
chr11_46574459_T_A_dose:bmi5
|
1.136*** (1.083, 1.188)
|
1.107* (1.024, 1.190)
|
1.156*** (1.087, 1.225)
|
|
Constant
|
1.403 (1.000, 1.806)
|
1.537 (1.096, 1.979)
|
0.344*** (0.147, 0.541)
|
|
|
|
Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 1.9279e-06
|
|
|
GxE term LRtest p = 1.5750e-02
|
|
|
GxE term LRtest p = 3.3168e-05
|
GxE model by tumor site
cancer_site_sum2 stratified chr11_46574459_T_A_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
|
Distal (Ca=10928,Co=48451)
|
Rectal (Ca=9200,Co=48451)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr11_46574459_T_A_dose
|
0.509*** (0.218, 0.800)
|
0.583* (0.127, 1.039)
|
0.509** (0.074, 0.943)
|
0.383*** (-0.079, 0.844)
|
|
bmi5
|
1.133*** (1.117, 1.150)
|
1.189*** (1.164, 1.215)
|
1.137*** (1.112, 1.161)
|
1.071*** (1.043, 1.099)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
0.997* (0.995, 1.000)
|
1.020*** (1.017, 1.022)
|
0.992*** (0.989, 0.994)
|
|
sex
|
1.111*** (1.079, 1.142)
|
1.060* (1.010, 1.109)
|
0.844*** (0.795, 0.892)
|
1.301*** (1.250, 1.352)
|
|
chr11_46574459_T_A_dose:bmi5
|
1.136*** (1.083, 1.188)
|
1.106* (1.024, 1.187)
|
1.136** (1.058, 1.214)
|
1.211*** (1.128, 1.294)
|
|
Constant
|
1.403 (1.000, 1.806)
|
0.467** (-0.060, 0.993)
|
0.211*** (-0.307, 0.728)
|
2.019** (1.554, 2.483)
|
|
|
|
Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 1.9279e-06
|
|
|
GxE term LRtest p = 1.6093e-02
|
|
|
GxE term LRtest p = 1.3937e-03
|
|
|
GxE term LRtest p = 6.2685e-06
|
Stratified OR
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
TT
|
TA
|
AA
|
TA
|
AA
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
0.84 (0.77-0.92)
|
1.22 (0.77-1.94)
|
0.84 (0.77-0.92)
|
1.22 (0.77-1.94)
|
10767.5/15529.1
|
1057.7/1664.1
|
44.8/51.8
|
|
p0
|
P= 1
|
P= 0.00012
|
P= 0.4
|
P= 0.00012
|
P= 0.4
|
|
|
|
|
bmic3f=Overweight
|
1.1 (1.06-1.14)
|
1.15 (1.06-1.24)
|
1.69 (1.11-2.6)
|
1.05 (0.97-1.13)
|
1.55 (1.01-2.37)
|
13870.9/18768
|
1524.5/1858.6
|
62.6/52.3
|
|
p1
|
P= 3.6e-07
|
P= 0.00081
|
P= 0.016
|
P= 0.26
|
P= 0.046
|
|
|
|
|
bmic3f=Obese
|
1.33 (1.27-1.38)
|
1.53 (1.37-1.7)
|
2.19 (1.24-3.86)
|
1.15 (1.03-1.28)
|
1.65 (0.93-2.91)
|
8114.1/9600.4
|
932/900
|
40.9/26.6
|
|
p2
|
P= 4.1e-41
|
P= 5.9e-15
|
P= 0.007
|
P= 0.011
|
P= 0.086
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.1 (1.06-1.14)
|
1.37 (1.22-1.54)
|
1.39 (0.74-2.61)
|
|
|
|
|
|
|
p1 (G)
|
P= 3.6e-07
|
P= 6e-08
|
P= 0.31
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.33 (1.27-1.38)
|
1.83 (1.6-2.09)
|
1.79 (0.86-3.73)
|
|
|
|
|
|
|
p2 (G)
|
P= 4.1e-41
|
P= 1e-18
|
P= 0.12
|
|
|
|
|
|
Stratified OR (adj smk_ever)
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
TT
|
TA
|
AA
|
TA
|
AA
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
0.84 (0.77-0.93)
|
1.25 (0.79-1.99)
|
0.84 (0.77-0.93)
|
1.25 (0.79-1.99)
|
10495.2/15328.6
|
1034/1635.6
|
44.8/51.8
|
|
p0
|
P= 1
|
P= 0.00028
|
P= 0.35
|
P= 0.00028
|
P= 0.35
|
|
|
|
|
bmic3f=Overweight
|
1.1 (1.07-1.14)
|
1.16 (1.07-1.25)
|
1.7 (1.11-2.6)
|
1.05 (0.97-1.14)
|
1.54 (1-2.36)
|
13512/18464.8
|
1498.5/1839.8
|
62.5/52.3
|
|
p1
|
P= 6.1e-08
|
P= 0.00044
|
P= 0.015
|
P= 0.26
|
P= 0.048
|
|
|
|
|
bmic3f=Obese
|
1.34 (1.29-1.4)
|
1.55 (1.39-1.73)
|
2.37 (1.33-4.22)
|
1.16 (1.04-1.29)
|
1.77 (0.99-3.15)
|
7927.7/9456.5
|
916.5/883.8
|
40.8/25.7
|
|
p2
|
P= 6.3e-43
|
P= 1.2e-15
|
P= 0.0033
|
P= 0.0094
|
P= 0.053
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.1 (1.07-1.14)
|
1.37 (1.22-1.54)
|
1.36 (0.72-2.55)
|
|
|
|
|
|
|
p1 (G)
|
P= 6.1e-08
|
P= 8.1e-08
|
P= 0.34
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.34 (1.29-1.4)
|
1.84 (1.61-2.1)
|
1.9 (0.91-3.97)
|
|
|
|
|
|
|
p2 (G)
|
P= 6.3e-43
|
P= 9.3e-19
|
P= 0.089
|
|
|
|
|
|
Locuszoom

Func Annot

chr11_47328213_T_C
Allele freq

GxE model by sex
sex stratified chr11_47328213_T_C_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr11_47328213_T_C_dose
|
0.425*** (0.088, 0.762)
|
0.339*** (-0.109, 0.786)
|
0.594* (0.076, 1.112)
|
|
bmi5
|
1.135*** (1.118, 1.151)
|
1.094*** (1.073, 1.115)
|
1.202*** (1.177, 1.228)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.006*** (1.003, 1.008)
|
1.009*** (1.007, 1.011)
|
|
sex
|
1.110*** (1.079, 1.142)
|
|
|
|
chr11_47328213_T_C_dose:bmi5
|
1.173*** (1.112, 1.235)
|
1.228*** (1.147, 1.310)
|
1.101* (1.007, 1.195)
|
|
Constant
|
1.397 (0.994, 1.800)
|
0.461*** (0.240, 0.683)
|
1.031 (0.604, 1.458)
|
|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 2.4160e-07
|
|
|
GxE term LRtest p = 5.2529e-07
|
|
|
GxE term LRtest p = 4.3252e-02
|
GxE model by study design
study_design stratified chr11_47328213_T_C_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
|
Case-Control (Ca=20557,Co=19763)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr11_47328213_T_C_dose
|
0.425*** (0.088, 0.762)
|
0.427** (-0.107, 0.962)
|
0.423*** (-0.013, 0.860)
|
|
bmi5
|
1.135*** (1.118, 1.151)
|
1.135*** (1.111, 1.158)
|
1.133*** (1.111, 1.156)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
|
1.008*** (1.006, 1.010)
|
|
sex
|
1.110*** (1.079, 1.142)
|
1.165*** (1.116, 1.214)
|
1.074*** (1.033, 1.115)
|
|
chr11_47328213_T_C_dose:bmi5
|
1.173*** (1.112, 1.235)
|
1.169** (1.072, 1.266)
|
1.176*** (1.097, 1.255)
|
|
Constant
|
1.397 (0.994, 1.800)
|
1.541 (1.099, 1.982)
|
0.341*** (0.145, 0.537)
|
|
|
|
Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 2.4160e-07
|
|
|
GxE term LRtest p = 1.5831e-03
|
|
|
GxE term LRtest p = 4.7385e-05
|
GxE model by tumor site
cancer_site_sum2 stratified chr11_47328213_T_C_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
|
Distal (Ca=10928,Co=48451)
|
Rectal (Ca=9200,Co=48451)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr11_47328213_T_C_dose
|
0.425*** (0.088, 0.762)
|
0.425** (-0.103, 0.954)
|
0.345*** (-0.157, 0.846)
|
0.457** (-0.083, 0.997)
|
|
bmi5
|
1.135*** (1.118, 1.151)
|
1.187*** (1.162, 1.213)
|
1.134*** (1.110, 1.159)
|
1.081*** (1.054, 1.108)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
0.997* (0.995, 1.000)
|
1.020*** (1.017, 1.022)
|
0.992*** (0.989, 0.994)
|
|
sex
|
1.110*** (1.079, 1.142)
|
1.059* (1.009, 1.109)
|
0.844*** (0.795, 0.892)
|
1.300*** (1.250, 1.351)
|
|
chr11_47328213_T_C_dose:bmi5
|
1.173*** (1.112, 1.235)
|
1.173*** (1.079, 1.268)
|
1.223*** (1.133, 1.313)
|
1.162** (1.064, 1.259)
|
|
Constant
|
1.397 (0.994, 1.800)
|
0.470** (-0.055, 0.996)
|
0.213*** (-0.304, 0.730)
|
1.930** (1.466, 2.393)
|
|
|
|
Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 2.4160e-07
|
|
|
GxE term LRtest p = 9.2266e-04
|
|
|
GxE term LRtest p = 1.1511e-05
|
|
|
GxE term LRtest p = 2.6590e-03
|
Stratified OR
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
TT
|
TC
|
CC
|
TC
|
CC
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
0.85 (0.77-0.94)
|
1.02 (0.57-1.85)
|
0.85 (0.77-0.94)
|
1.02 (0.57-1.85)
|
11020.6/15925.1
|
823.3/1287.6
|
26.1/32.4
|
|
p0
|
P= 1
|
P= 0.0018
|
P= 0.93
|
P= 0.0018
|
P= 0.93
|
|
|
|
|
bmic3f=Overweight
|
1.1 (1.07-1.14)
|
1.16 (1.06-1.27)
|
1.4 (0.79-2.47)
|
1.05 (0.96-1.15)
|
1.26 (0.72-2.24)
|
14270/19265.8
|
1155.4/1382.4
|
32.6/30.8
|
|
p1
|
P= 3.3e-08
|
P= 0.0017
|
P= 0.25
|
P= 0.31
|
P= 0.42
|
|
|
|
|
bmic3f=Obese
|
1.34 (1.28-1.39)
|
1.62 (1.44-1.83)
|
1.37 (0.66-2.85)
|
1.22 (1.07-1.38)
|
1.03 (0.5-2.13)
|
8356.6/9859.6
|
710/649.3
|
20.4/18.1
|
|
p2
|
P= 5.9e-44
|
P= 7.7e-15
|
P= 0.39
|
P= 0.0021
|
P= 0.94
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.1 (1.07-1.14)
|
1.36 (1.19-1.55)
|
1.36 (0.6-3.09)
|
|
|
|
|
|
|
p1 (G)
|
P= 3.3e-08
|
P= 3.6e-06
|
P= 0.46
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.34 (1.28-1.39)
|
1.91 (1.64-2.22)
|
1.34 (0.53-3.42)
|
|
|
|
|
|
|
p2 (G)
|
P= 5.9e-44
|
P= 1.4e-16
|
P= 0.54
|
|
|
|
|
|
Stratified OR (adj smk_ever)
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
TT
|
TC
|
CC
|
TC
|
CC
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
0.86 (0.78-0.96)
|
1.07 (0.59-1.94)
|
0.86 (0.78-0.96)
|
1.07 (0.59-1.94)
|
10738.4/15720
|
809.5/1264
|
26.1/32
|
|
p0
|
P= 1
|
P= 0.0053
|
P= 0.82
|
P= 0.0053
|
P= 0.82
|
|
|
|
|
bmic3f=Overweight
|
1.11 (1.07-1.15)
|
1.16 (1.06-1.27)
|
1.41 (0.8-2.49)
|
1.04 (0.95-1.14)
|
1.27 (0.72-2.24)
|
13909.4/18959.9
|
1131.1/1366.4
|
32.5/30.7
|
|
p1
|
P= 3.7e-09
|
P= 0.0015
|
P= 0.24
|
P= 0.36
|
P= 0.42
|
|
|
|
|
bmic3f=Obese
|
1.35 (1.3-1.41)
|
1.63 (1.44-1.84)
|
1.5 (0.71-3.15)
|
1.21 (1.07-1.37)
|
1.11 (0.53-2.34)
|
8167.6/9708.4
|
697.2/640.5
|
20.3/17.1
|
|
p2
|
P= 3e-46
|
P= 7e-15
|
P= 0.29
|
P= 0.0031
|
P= 0.78
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.11 (1.07-1.15)
|
1.34 (1.18-1.53)
|
1.31 (0.58-2.98)
|
|
|
|
|
|
|
p1 (G)
|
P= 3.7e-09
|
P= 1.1e-05
|
P= 0.51
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.35 (1.3-1.41)
|
1.89 (1.62-2.2)
|
1.4 (0.54-3.62)
|
|
|
|
|
|
|
p2 (G)
|
P= 3e-46
|
P= 8.1e-16
|
P= 0.49
|
|
|
|
|
|
Locuszoom

Func Annot

chr15_33122966_C_T
Allele freq

GxE model by sex
sex stratified chr15_33122966_C_T_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr15_33122966_C_T_dose
|
1.501*** (1.352, 1.649)
|
1.521*** (1.329, 1.713)
|
1.456** (1.220, 1.691)
|
|
bmi5
|
1.178*** (1.159, 1.197)
|
1.139*** (1.114, 1.164)
|
1.240*** (1.210, 1.271)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.006*** (1.003, 1.008)
|
1.009*** (1.007, 1.011)
|
|
sex
|
1.110*** (1.078, 1.141)
|
|
|
|
chr15_33122966_C_T_dose:bmi5
|
0.939*** (0.913, 0.966)
|
0.939*** (0.904, 0.974)
|
0.944** (0.902, 0.987)
|
|
Constant
|
1.116 (0.709, 1.523)
|
0.360*** (0.127, 0.593)
|
0.850 (0.414, 1.287)
|
|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 4.9681e-06
|
|
|
GxE term LRtest p = 3.7163e-04
|
|
|
GxE term LRtest p = 7.9671e-03
|
GxE model by study design
study_design stratified chr15_33122966_C_T_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
|
Case-Control (Ca=20557,Co=19763)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr15_33122966_C_T_dose
|
1.501*** (1.352, 1.649)
|
1.584*** (1.369, 1.799)
|
1.427*** (1.222, 1.632)
|
|
bmi5
|
1.178*** (1.159, 1.197)
|
1.180*** (1.152, 1.208)
|
1.175*** (1.149, 1.201)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
|
1.008*** (1.006, 1.010)
|
|
sex
|
1.110*** (1.078, 1.141)
|
1.165*** (1.116, 1.214)
|
1.073*** (1.032, 1.114)
|
|
chr15_33122966_C_T_dose:bmi5
|
0.939*** (0.913, 0.966)
|
0.932*** (0.893, 0.971)
|
0.946** (0.909, 0.983)
|
|
Constant
|
1.116 (0.709, 1.523)
|
1.215 (0.766, 1.665)
|
0.274*** (0.064, 0.484)
|
|
|
|
Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 4.9681e-06
|
|
|
GxE term LRtest p = 4.0843e-04
|
|
|
GxE term LRtest p = 3.3760e-03
|
GxE model by tumor site
cancer_site_sum2 stratified chr15_33122966_C_T_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
|
Distal (Ca=10928,Co=48451)
|
Rectal (Ca=9200,Co=48451)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr15_33122966_C_T_dose
|
1.501*** (1.352, 1.649)
|
1.548*** (1.315, 1.782)
|
1.528*** (1.304, 1.751)
|
1.562*** (1.314, 1.810)
|
|
bmi5
|
1.178*** (1.159, 1.197)
|
1.237*** (1.207, 1.266)
|
1.183*** (1.155, 1.212)
|
1.124*** (1.092, 1.156)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
0.997* (0.995, 1.000)
|
1.020*** (1.017, 1.022)
|
0.992*** (0.989, 0.994)
|
|
sex
|
1.110*** (1.078, 1.141)
|
1.059* (1.009, 1.109)
|
0.843*** (0.794, 0.891)
|
1.299*** (1.248, 1.350)
|
|
chr15_33122966_C_T_dose:bmi5
|
0.939*** (0.913, 0.966)
|
0.931*** (0.889, 0.973)
|
0.935** (0.895, 0.975)
|
0.936** (0.891, 0.981)
|
|
Constant
|
1.116 (0.709, 1.523)
|
0.370*** (-0.164, 0.903)
|
0.165*** (-0.359, 0.690)
|
1.528 (1.056, 2.001)
|
|
|
|
Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 4.9681e-06
|
|
|
GxE term LRtest p = 7.3858e-04
|
|
|
GxE term LRtest p = 1.0582e-03
|
|
|
GxE term LRtest p = 3.8049e-03
|
Stratified OR
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.12 (1.06-1.18)
|
1.26 (1.12-1.43)
|
1.12 (1.06-1.18)
|
1.26 (1.12-1.43)
|
7382/11094.8
|
3938.6/5459
|
549.5/691.3
|
|
p0
|
P= 1
|
P= 4.3e-05
|
P= 0.0002
|
P= 4.3e-05
|
P= 0.0002
|
|
|
|
|
bmic3f=Overweight
|
1.13 (1.08-1.18)
|
1.25 (1.19-1.31)
|
1.28 (1.14-1.43)
|
1.1 (1.05-1.16)
|
1.13 (1.01-1.27)
|
9678.1/13327.5
|
5114.5/6524.9
|
665.5/826.6
|
|
p1
|
P= 7.7e-09
|
P= 4e-18
|
P= 1.7e-05
|
P= 5.8e-05
|
P= 0.029
|
|
|
|
|
bmic3f=Obese
|
1.45 (1.38-1.52)
|
1.43 (1.34-1.52)
|
1.26 (1.09-1.47)
|
0.99 (0.92-1.05)
|
0.87 (0.75-1.02)
|
5812.3/6625.6
|
2924.4/3436.3
|
350.2/465.1
|
|
p2
|
P= 3.9e-50
|
P= 2.9e-30
|
P= 0.0022
|
P= 0.65
|
P= 0.077
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.13 (1.08-1.18)
|
1.12 (1.05-1.18)
|
1.02 (0.86-1.19)
|
|
|
|
|
|
|
p1 (G)
|
P= 7.7e-09
|
P= 0.00021
|
P= 0.85
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.45 (1.38-1.52)
|
1.28 (1.19-1.37)
|
1 (0.83-1.21)
|
|
|
|
|
|
|
p2 (G)
|
P= 3.9e-50
|
P= 1.5e-12
|
P= 0.98
|
|
|
|
|
|
Stratified OR (adj smk_ever)
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.11 (1.06-1.18)
|
1.28 (1.13-1.45)
|
1.11 (1.06-1.18)
|
1.28 (1.13-1.45)
|
7196.4/10942.9
|
3834.3/5391.8
|
543.3/681.3
|
|
p0
|
P= 1
|
P= 8.5e-05
|
P= 8.9e-05
|
P= 8.5e-05
|
P= 8.9e-05
|
|
|
|
|
bmic3f=Overweight
|
1.14 (1.09-1.19)
|
1.25 (1.19-1.32)
|
1.28 (1.15-1.44)
|
1.1 (1.05-1.15)
|
1.13 (1.01-1.26)
|
9441.2/13112.5
|
4987.3/6432.6
|
644.5/811.9
|
|
p1
|
P= 1.5e-09
|
P= 2.4e-18
|
P= 1.7e-05
|
P= 0.00012
|
P= 0.038
|
|
|
|
|
bmic3f=Obese
|
1.46 (1.39-1.54)
|
1.44 (1.36-1.54)
|
1.29 (1.11-1.5)
|
0.99 (0.93-1.05)
|
0.88 (0.76-1.03)
|
5680.3/6533.6
|
2860.4/3376.3
|
344.2/456.1
|
|
p2
|
P= 4.2e-51
|
P= 2.4e-31
|
P= 0.00098
|
P= 0.72
|
P= 0.11
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.14 (1.09-1.19)
|
1.12 (1.06-1.19)
|
1 (0.85-1.18)
|
|
|
|
|
|
|
p1 (G)
|
P= 1.5e-09
|
P= 9.6e-05
|
P= 0.96
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.46 (1.39-1.54)
|
1.3 (1.21-1.39)
|
1.01 (0.83-1.22)
|
|
|
|
|
|
|
p2 (G)
|
P= 4.2e-51
|
P= 1.5e-13
|
P= 0.93
|
|
|
|
|
|
Locuszoom

Func Annot

chr2_10961902_T_C
Allele freq

GxE model by sex
sex stratified chr2_10961902_T_C_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr2_10961902_T_C_dose
|
1.359*** (1.224, 1.493)
|
1.389*** (1.215, 1.564)
|
1.308* (1.095, 1.520)
|
|
bmi5
|
1.185*** (1.165, 1.206)
|
1.150*** (1.123, 1.176)
|
1.246*** (1.214, 1.278)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.006*** (1.003, 1.008)
|
1.009*** (1.007, 1.011)
|
|
sex
|
1.110*** (1.078, 1.141)
|
|
|
|
chr2_10961902_T_C_dose:bmi5
|
0.942*** (0.918, 0.967)
|
0.938*** (0.906, 0.969)
|
0.949** (0.911, 0.987)
|
|
Constant
|
1.116 (0.707, 1.524)
|
0.359*** (0.121, 0.597)
|
0.860 (0.420, 1.301)
|
|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 1.5633e-06
|
|
|
GxE term LRtest p = 6.8194e-05
|
|
|
GxE term LRtest p = 7.3187e-03
|
GxE model by study design
study_design stratified chr2_10961902_T_C_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
|
Case-Control (Ca=20557,Co=19763)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr2_10961902_T_C_dose
|
1.359*** (1.224, 1.493)
|
1.360** (1.164, 1.556)
|
1.359** (1.173, 1.544)
|
|
bmi5
|
1.185*** (1.165, 1.206)
|
1.184*** (1.154, 1.213)
|
1.186*** (1.158, 1.214)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
|
1.008*** (1.006, 1.010)
|
|
sex
|
1.110*** (1.078, 1.141)
|
1.165*** (1.116, 1.214)
|
1.073*** (1.033, 1.114)
|
|
chr2_10961902_T_C_dose:bmi5
|
0.942*** (0.918, 0.967)
|
0.941*** (0.906, 0.977)
|
0.943*** (0.910, 0.976)
|
|
Constant
|
1.116 (0.707, 1.524)
|
1.241 (0.788, 1.693)
|
0.270*** (0.053, 0.486)
|
|
|
|
Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 1.5633e-06
|
|
|
GxE term LRtest p = 8.2868e-04
|
|
|
GxE term LRtest p = 5.6437e-04
|
GxE model by tumor site
cancer_site_sum2 stratified chr2_10961902_T_C_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
|
Distal (Ca=10928,Co=48451)
|
Rectal (Ca=9200,Co=48451)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr2_10961902_T_C_dose
|
1.359*** (1.224, 1.493)
|
1.308* (1.096, 1.519)
|
1.566*** (1.362, 1.771)
|
1.253 (1.026, 1.480)
|
|
bmi5
|
1.185*** (1.165, 1.206)
|
1.237*** (1.205, 1.268)
|
1.207*** (1.177, 1.237)
|
1.121*** (1.086, 1.155)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
0.997* (0.995, 1.000)
|
1.020*** (1.017, 1.022)
|
0.992*** (0.989, 0.994)
|
|
sex
|
1.110*** (1.078, 1.141)
|
1.059* (1.009, 1.109)
|
0.843*** (0.794, 0.891)
|
1.300*** (1.249, 1.350)
|
|
chr2_10961902_T_C_dose:bmi5
|
0.942*** (0.918, 0.967)
|
0.948** (0.910, 0.986)
|
0.916*** (0.879, 0.953)
|
0.956* (0.915, 0.998)
|
|
Constant
|
1.116 (0.707, 1.524)
|
0.382*** (-0.154, 0.918)
|
0.155*** (-0.372, 0.683)
|
1.608 (1.130, 2.085)
|
|
|
|
Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 1.5633e-06
|
|
|
GxE term LRtest p = 5.2914e-03
|
|
|
GxE term LRtest p = 2.9088e-06
|
|
|
GxE term LRtest p = 3.3274e-02
|
Stratified OR
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
TT
|
TC
|
CC
|
TC
|
CC
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.02 (0.97-1.08)
|
1.03 (0.93-1.13)
|
1.02 (0.97-1.08)
|
1.03 (0.93-1.13)
|
6390/9412.3
|
4621.9/6605.9
|
858.1/1226.8
|
|
p0
|
P= 1
|
P= 0.39
|
P= 0.56
|
P= 0.39
|
P= 0.56
|
|
|
|
|
bmic3f=Overweight
|
1.14 (1.09-1.2)
|
1.12 (1.06-1.17)
|
1.15 (1.05-1.25)
|
0.98 (0.93-1.02)
|
1.01 (0.92-1.1)
|
8331.7/11075.1
|
5968.5/8062.2
|
1157.8/1541.7
|
|
p1
|
P= 7e-09
|
P= 1e-05
|
P= 0.0017
|
P= 0.32
|
P= 0.89
|
|
|
|
|
bmic3f=Obese
|
1.45 (1.38-1.53)
|
1.34 (1.26-1.42)
|
1.2 (1.07-1.35)
|
0.92 (0.87-0.98)
|
0.83 (0.74-0.93)
|
4967.1/5535.6
|
3484.8/4165.2
|
635.1/826.2
|
|
p2
|
P= 5e-43
|
P= 2.8e-22
|
P= 0.0015
|
P= 0.01
|
P= 0.0018
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.14 (1.09-1.2)
|
1.09 (1.03-1.15)
|
1.12 (0.99-1.26)
|
|
|
|
|
|
|
p1 (G)
|
P= 7e-09
|
P= 0.0013
|
P= 0.075
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.45 (1.38-1.53)
|
1.31 (1.23-1.39)
|
1.17 (1.01-1.35)
|
|
|
|
|
|
|
p2 (G)
|
P= 5e-43
|
P= 3.8e-17
|
P= 0.031
|
|
|
|
|
|
Stratified OR (adj smk_ever)
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
TT
|
TC
|
CC
|
TC
|
CC
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.02 (0.97-1.08)
|
1.03 (0.93-1.13)
|
1.02 (0.97-1.08)
|
1.03 (0.93-1.13)
|
6232/9280.7
|
4508.2/6521.6
|
833.9/1213.8
|
|
p0
|
P= 1
|
P= 0.42
|
P= 0.59
|
P= 0.42
|
P= 0.59
|
|
|
|
|
bmic3f=Overweight
|
1.15 (1.1-1.2)
|
1.12 (1.07-1.18)
|
1.15 (1.05-1.25)
|
0.98 (0.93-1.02)
|
1 (0.91-1.09)
|
8136.1/10909.1
|
5820/7932.2
|
1116.9/1515.7
|
|
p1
|
P= 1.8e-09
|
P= 4.8e-06
|
P= 0.0024
|
P= 0.3
|
P= 0.95
|
|
|
|
|
bmic3f=Obese
|
1.46 (1.39-1.54)
|
1.35 (1.27-1.43)
|
1.2 (1.07-1.35)
|
0.92 (0.87-0.98)
|
0.82 (0.73-0.92)
|
4859/5447.7
|
3405.9/4101.4
|
620/816.9
|
|
p2
|
P= 5.2e-44
|
P= 1.9e-23
|
P= 0.0018
|
P= 0.014
|
P= 0.0011
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.15 (1.1-1.2)
|
1.1 (1.04-1.16)
|
1.12 (0.99-1.26)
|
|
|
|
|
|
|
p1 (G)
|
P= 1.8e-09
|
P= 0.00061
|
P= 0.08
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.46 (1.39-1.54)
|
1.32 (1.24-1.41)
|
1.17 (1.01-1.35)
|
|
|
|
|
|
|
p2 (G)
|
P= 5.2e-44
|
P= 2.5e-18
|
P= 0.033
|
|
|
|
|
|
Locuszoom

Func Annot

chr2_217410559_G_A
Allele freq

GxE model by sex
sex stratified chr2_217410559_G_A_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr2_217410559_G_A_dose
|
2.182*** (1.833, 2.531)
|
2.238*** (1.785, 2.691)
|
2.037* (1.484, 2.590)
|
|
bmi5
|
1.159*** (1.143, 1.175)
|
1.122*** (1.101, 1.142)
|
1.222*** (1.197, 1.247)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.006*** (1.003, 1.008)
|
1.009*** (1.007, 1.011)
|
|
sex
|
1.110*** (1.078, 1.141)
|
|
|
|
chr2_217410559_G_A_dose:bmi5
|
0.859*** (0.796, 0.922)
|
0.854*** (0.772, 0.936)
|
0.870** (0.771, 0.970)
|
|
Constant
|
1.247 (0.844, 1.650)
|
0.407*** (0.186, 0.628)
|
0.946 (0.519, 1.372)
|
|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 2.1518e-06
|
|
|
GxE term LRtest p = 1.5376e-04
|
|
|
GxE term LRtest p = 6.2497e-03
|
GxE model by study design
study_design stratified chr2_217410559_G_A_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
|
Case-Control (Ca=20557,Co=19763)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr2_217410559_G_A_dose
|
2.182*** (1.833, 2.531)
|
2.100** (1.576, 2.625)
|
2.244*** (1.776, 2.712)
|
|
bmi5
|
1.159*** (1.143, 1.175)
|
1.155*** (1.132, 1.179)
|
1.161*** (1.139, 1.183)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
|
1.008*** (1.006, 1.010)
|
|
sex
|
1.110*** (1.078, 1.141)
|
1.165*** (1.116, 1.214)
|
1.074*** (1.033, 1.115)
|
|
chr2_217410559_G_A_dose:bmi5
|
0.859*** (0.796, 0.922)
|
0.866** (0.771, 0.961)
|
0.854*** (0.770, 0.938)
|
|
Constant
|
1.247 (0.844, 1.650)
|
1.394 (0.952, 1.835)
|
0.301*** (0.106, 0.497)
|
|
|
|
Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 2.1518e-06
|
|
|
GxE term LRtest p = 2.7869e-03
|
|
|
GxE term LRtest p = 2.4341e-04
|
GxE model by tumor site
cancer_site_sum2 stratified chr2_217410559_G_A_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
|
Distal (Ca=10928,Co=48451)
|
Rectal (Ca=9200,Co=48451)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr2_217410559_G_A_dose
|
2.182*** (1.833, 2.531)
|
3.340*** (2.779, 3.901)
|
1.473 (0.941, 2.005)
|
2.480** (1.875, 3.086)
|
|
bmi5
|
1.159*** (1.143, 1.175)
|
1.219*** (1.194, 1.244)
|
1.158*** (1.134, 1.182)
|
1.106*** (1.079, 1.133)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
0.997* (0.995, 1.000)
|
1.019*** (1.017, 1.022)
|
0.992*** (0.989, 0.994)
|
|
sex
|
1.110*** (1.078, 1.141)
|
1.059* (1.009, 1.109)
|
0.843*** (0.795, 0.892)
|
1.300*** (1.249, 1.351)
|
|
chr2_217410559_G_A_dose:bmi5
|
0.859*** (0.796, 0.922)
|
0.793*** (0.691, 0.895)
|
0.920 (0.825, 1.015)
|
0.839** (0.729, 0.950)
|
|
Constant
|
1.247 (0.844, 1.650)
|
0.408*** (-0.117, 0.934)
|
0.191*** (-0.326, 0.708)
|
1.710* (1.247, 2.173)
|
|
|
|
Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 2.1518e-06
|
|
|
GxE term LRtest p = 4.7942e-06
|
|
|
GxE term LRtest p = 8.4947e-02
|
|
|
GxE term LRtest p = 1.5612e-03
|
Stratified OR
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
GG
|
GA
|
AA
|
GA
|
AA
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.09 (0.98-1.21)
|
1.1 (0.51-2.35)
|
1.09 (0.98-1.21)
|
1.1 (0.51-2.35)
|
11113.9/16250.3
|
741.7/977.2
|
14.4/17.5
|
|
p0
|
P= 1
|
P= 0.1
|
P= 0.81
|
P= 0.1
|
P= 0.81
|
|
|
|
|
bmic3f=Overweight
|
1.13 (1.09-1.17)
|
1.08 (0.98-1.19)
|
0.75 (0.37-1.52)
|
0.96 (0.87-1.05)
|
0.66 (0.32-1.35)
|
14534.9/19428.4
|
909.1/1230.2
|
14/20.4
|
|
p1
|
P= 3.5e-12
|
P= 0.11
|
P= 0.42
|
P= 0.37
|
P= 0.25
|
|
|
|
|
bmic3f=Obese
|
1.4 (1.34-1.46)
|
1.11 (0.98-1.26)
|
0.73 (0.29-1.81)
|
0.8 (0.7-0.9)
|
0.52 (0.21-1.29)
|
8568.4/9829.8
|
510.5/682.8
|
8.1/14.4
|
|
p2
|
P= 1.7e-59
|
P= 0.098
|
P= 0.49
|
P= 0.00044
|
P= 0.16
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.13 (1.09-1.17)
|
0.99 (0.86-1.14)
|
0.68 (0.24-1.92)
|
|
|
|
|
|
|
p1 (G)
|
P= 3.5e-12
|
P= 0.89
|
P= 0.47
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.4 (1.34-1.46)
|
1.02 (0.87-1.2)
|
0.66 (0.2-2.16)
|
|
|
|
|
|
|
p2 (G)
|
P= 1.7e-59
|
P= 0.83
|
P= 0.49
|
|
|
|
|
|
Stratified OR (adj smk_ever)
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
GG
|
GA
|
AA
|
GA
|
AA
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.1 (0.99-1.22)
|
1.13 (0.53-2.41)
|
1.1 (0.99-1.22)
|
1.13 (0.53-2.41)
|
10833.5/16034.6
|
726.1/963.9
|
14.4/17.5
|
|
p0
|
P= 1
|
P= 0.082
|
P= 0.76
|
P= 0.082
|
P= 0.76
|
|
|
|
|
bmic3f=Overweight
|
1.14 (1.1-1.18)
|
1.09 (0.99-1.2)
|
0.77 (0.37-1.58)
|
0.96 (0.87-1.05)
|
0.67 (0.33-1.38)
|
14170/19123.5
|
889/1214.1
|
14/19.4
|
|
p1
|
P= 4e-13
|
P= 0.092
|
P= 0.47
|
P= 0.35
|
P= 0.28
|
|
|
|
|
bmic3f=Obese
|
1.41 (1.36-1.47)
|
1.11 (0.98-1.26)
|
0.85 (0.34-2.15)
|
0.79 (0.69-0.9)
|
0.6 (0.24-1.52)
|
8382.7/9680.9
|
494.2/671.7
|
8.1/13.4
|
|
p2
|
P= 8.2e-62
|
P= 0.11
|
P= 0.73
|
P= 0.00028
|
P= 0.28
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.14 (1.1-1.18)
|
0.99 (0.86-1.14)
|
0.68 (0.24-1.94)
|
|
|
|
|
|
|
p1 (G)
|
P= 4e-13
|
P= 0.87
|
P= 0.47
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.41 (1.36-1.47)
|
1.01 (0.86-1.19)
|
0.76 (0.23-2.5)
|
|
|
|
|
|
|
p2 (G)
|
P= 8.2e-62
|
P= 0.9
|
P= 0.65
|
|
|
|
|
|
Locuszoom

Func Annot

chr3_100037644_A_G
Allele freq

GxE model by sex
sex stratified chr3_100037644_A_G_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr3_100037644_A_G_dose
|
1.376*** (1.241, 1.512)
|
1.355*** (1.178, 1.532)
|
1.409** (1.195, 1.623)
|
|
bmi5
|
1.188*** (1.167, 1.208)
|
1.146*** (1.119, 1.173)
|
1.257*** (1.224, 1.289)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.006*** (1.003, 1.008)
|
1.009*** (1.007, 1.011)
|
|
sex
|
1.110*** (1.079, 1.142)
|
|
|
|
chr3_100037644_A_G_dose:bmi5
|
0.942*** (0.917, 0.966)
|
0.945*** (0.913, 0.977)
|
0.937*** (0.898, 0.975)
|
|
Constant
|
1.097 (0.687, 1.506)
|
0.360*** (0.119, 0.601)
|
0.818 (0.375, 1.260)
|
|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 1.5427e-06
|
|
|
GxE term LRtest p = 5.9801e-04
|
|
|
GxE term LRtest p = 8.6449e-04
|
GxE model by study design
study_design stratified chr3_100037644_A_G_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
|
Case-Control (Ca=20557,Co=19763)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr3_100037644_A_G_dose
|
1.376*** (1.241, 1.512)
|
1.314** (1.117, 1.511)
|
1.439*** (1.251, 1.627)
|
|
bmi5
|
1.188*** (1.167, 1.208)
|
1.182*** (1.152, 1.213)
|
1.191*** (1.163, 1.220)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
|
1.008*** (1.006, 1.010)
|
|
sex
|
1.110*** (1.079, 1.142)
|
1.165*** (1.116, 1.214)
|
1.074*** (1.033, 1.115)
|
|
chr3_100037644_A_G_dose:bmi5
|
0.942*** (0.917, 0.966)
|
0.946** (0.910, 0.982)
|
0.937*** (0.904, 0.971)
|
|
Constant
|
1.097 (0.687, 1.506)
|
1.256 (0.801, 1.711)
|
0.259*** (0.038, 0.479)
|
|
|
|
Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 1.5427e-06
|
|
|
GxE term LRtest p = 2.2744e-03
|
|
|
GxE term LRtest p = 1.8727e-04
|
GxE model by tumor site
cancer_site_sum2 stratified chr3_100037644_A_G_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
|
Distal (Ca=10928,Co=48451)
|
Rectal (Ca=9200,Co=48451)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr3_100037644_A_G_dose
|
1.376*** (1.241, 1.512)
|
1.361** (1.146, 1.576)
|
1.339** (1.134, 1.544)
|
1.433** (1.203, 1.663)
|
|
bmi5
|
1.188*** (1.167, 1.208)
|
1.243*** (1.211, 1.275)
|
1.187*** (1.155, 1.218)
|
1.137*** (1.102, 1.172)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
0.997* (0.995, 1.000)
|
1.019*** (1.017, 1.022)
|
0.992*** (0.989, 0.994)
|
|
sex
|
1.110*** (1.079, 1.142)
|
1.060* (1.011, 1.110)
|
0.844*** (0.795, 0.892)
|
1.301*** (1.250, 1.352)
|
|
chr3_100037644_A_G_dose:bmi5
|
0.942*** (0.917, 0.966)
|
0.941** (0.902, 0.979)
|
0.948** (0.911, 0.985)
|
0.934** (0.892, 0.975)
|
|
Constant
|
1.097 (0.687, 1.506)
|
0.375*** (-0.163, 0.913)
|
0.166*** (-0.363, 0.696)
|
1.485 (1.006, 1.965)
|
|
|
|
Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 1.5427e-06
|
|
|
GxE term LRtest p = 1.8201e-03
|
|
|
GxE term LRtest p = 4.6890e-03
|
|
|
GxE term LRtest p = 1.2279e-03
|
Stratified OR
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
AA
|
AG
|
GG
|
AG
|
GG
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.03 (0.98-1.09)
|
1.19 (1.08-1.31)
|
1.03 (0.98-1.09)
|
1.19 (1.08-1.31)
|
6172.5/9201.1
|
4726.8/6798.9
|
970.7/1244.9
|
|
p0
|
P= 1
|
P= 0.21
|
P= 0.00042
|
P= 0.21
|
P= 0.00042
|
|
|
|
|
bmic3f=Overweight
|
1.17 (1.11-1.22)
|
1.14 (1.08-1.2)
|
1.11 (1.02-1.22)
|
0.98 (0.93-1.03)
|
0.95 (0.87-1.04)
|
8120.4/10805.7
|
6168.1/8276.2
|
1169.5/1597.1
|
|
p1
|
P= 9.4e-11
|
P= 2.2e-07
|
P= 0.019
|
P= 0.36
|
P= 0.29
|
|
|
|
|
bmic3f=Obese
|
1.49 (1.41-1.57)
|
1.33 (1.26-1.41)
|
1.29 (1.15-1.45)
|
0.9 (0.84-0.96)
|
0.87 (0.77-0.98)
|
4880.3/5388.9
|
3512.7/4284.4
|
694/853.6
|
|
p2
|
P= 1.3e-46
|
P= 3.5e-21
|
P= 1.2e-05
|
P= 0.00088
|
P= 0.019
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.17 (1.11-1.22)
|
1.1 (1.04-1.16)
|
0.93 (0.83-1.06)
|
|
|
|
|
|
|
p1 (G)
|
P= 9.4e-11
|
P= 0.00037
|
P= 0.27
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.49 (1.41-1.57)
|
1.29 (1.21-1.37)
|
1.09 (0.94-1.25)
|
|
|
|
|
|
|
p2 (G)
|
P= 1.3e-46
|
P= 3e-15
|
P= 0.26
|
|
|
|
|
|
Stratified OR (adj smk_ever)
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
AA
|
AG
|
GG
|
AG
|
GG
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.03 (0.98-1.09)
|
1.19 (1.08-1.31)
|
1.03 (0.98-1.09)
|
1.19 (1.08-1.31)
|
6031.6/9083.1
|
4594/6702.3
|
948.4/1230.6
|
|
p0
|
P= 1
|
P= 0.29
|
P= 0.00064
|
P= 0.29
|
P= 0.00064
|
|
|
|
|
bmic3f=Overweight
|
1.17 (1.12-1.23)
|
1.14 (1.09-1.2)
|
1.12 (1.03-1.23)
|
0.98 (0.93-1.02)
|
0.96 (0.88-1.05)
|
7926.7/10643.2
|
6004.2/8143.5
|
1142.1/1570.2
|
|
p1
|
P= 4.2e-11
|
P= 1.9e-07
|
P= 0.011
|
P= 0.32
|
P= 0.37
|
|
|
|
|
bmic3f=Obese
|
1.49 (1.41-1.58)
|
1.35 (1.27-1.43)
|
1.3 (1.16-1.46)
|
0.9 (0.84-0.96)
|
0.87 (0.77-0.98)
|
4769.8/5313.3
|
3435.2/4212.8
|
680/839.9
|
|
p2
|
P= 8.4e-47
|
P= 3.3e-22
|
P= 8e-06
|
P= 0.0018
|
P= 0.022
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.17 (1.12-1.23)
|
1.11 (1.05-1.17)
|
0.95 (0.84-1.07)
|
|
|
|
|
|
|
p1 (G)
|
P= 4.2e-11
|
P= 0.00016
|
P= 0.4
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.49 (1.41-1.58)
|
1.31 (1.23-1.39)
|
1.1 (0.95-1.27)
|
|
|
|
|
|
|
p2 (G)
|
P= 8.4e-47
|
P= 1.4e-16
|
P= 0.2
|
|
|
|
|
|
Locuszoom

Func Annot

chr6_138766021_C_T
Allele freq

GxE model by sex
sex stratified chr6_138766021_C_T_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr6_138766021_C_T_dose
|
0.537*** (0.276, 0.798)
|
0.616** (0.277, 0.954)
|
0.453*** (0.040, 0.866)
|
|
bmi5
|
1.131*** (1.115, 1.148)
|
1.098*** (1.076, 1.119)
|
1.189*** (1.162, 1.215)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.006*** (1.004, 1.008)
|
1.009*** (1.007, 1.011)
|
|
sex
|
1.111*** (1.079, 1.142)
|
|
|
|
chr6_138766021_C_T_dose:bmi5
|
1.120*** (1.073, 1.167)
|
1.095** (1.034, 1.157)
|
1.153*** (1.079, 1.228)
|
|
Constant
|
1.415 (1.012, 1.819)
|
0.454*** (0.231, 0.678)
|
1.095 (0.667, 1.524)
|
|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 2.1947e-06
|
|
|
GxE term LRtest p = 3.5392e-03
|
|
|
GxE term LRtest p = 1.5879e-04
|
GxE model by study design
study_design stratified chr6_138766021_C_T_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
|
Case-Control (Ca=20557,Co=19763)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr6_138766021_C_T_dose
|
0.537*** (0.276, 0.798)
|
0.628* (0.248, 1.008)
|
0.468*** (0.108, 0.828)
|
|
bmi5
|
1.131*** (1.115, 1.148)
|
1.132*** (1.108, 1.157)
|
1.129*** (1.106, 1.152)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
|
1.008*** (1.006, 1.010)
|
|
sex
|
1.111*** (1.079, 1.142)
|
1.166*** (1.117, 1.215)
|
1.075*** (1.034, 1.115)
|
|
chr6_138766021_C_T_dose:bmi5
|
1.120*** (1.073, 1.167)
|
1.097** (1.028, 1.166)
|
1.141*** (1.076, 1.206)
|
|
Constant
|
1.415 (1.012, 1.819)
|
1.538 (1.096, 1.980)
|
0.351*** (0.152, 0.550)
|
|
|
|
Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 2.1947e-06
|
|
|
GxE term LRtest p = 8.2124e-03
|
|
|
GxE term LRtest p = 5.8576e-05
|
GxE model by tumor site
cancer_site_sum2 stratified chr6_138766021_C_T_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
|
Distal (Ca=10928,Co=48451)
|
Rectal (Ca=9200,Co=48451)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr6_138766021_C_T_dose
|
0.537*** (0.276, 0.798)
|
0.419*** (0.009, 0.828)
|
0.630* (0.242, 1.017)
|
0.466*** (0.031, 0.901)
|
|
bmi5
|
1.131*** (1.115, 1.148)
|
1.178*** (1.152, 1.204)
|
1.139*** (1.114, 1.164)
|
1.073*** (1.045, 1.102)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
0.997* (0.995, 1.000)
|
1.020*** (1.017, 1.022)
|
0.992*** (0.989, 0.994)
|
|
sex
|
1.111*** (1.079, 1.142)
|
1.061* (1.011, 1.111)
|
0.844*** (0.795, 0.892)
|
1.302*** (1.251, 1.353)
|
|
chr6_138766021_C_T_dose:bmi5
|
1.120*** (1.073, 1.167)
|
1.163*** (1.091, 1.236)
|
1.092* (1.022, 1.162)
|
1.151*** (1.073, 1.229)
|
|
Constant
|
1.415 (1.012, 1.819)
|
0.496** (-0.031, 1.023)
|
0.207*** (-0.311, 0.725)
|
1.996** (1.531, 2.461)
|
|
|
|
Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 2.1947e-06
|
|
|
GxE term LRtest p = 4.5510e-05
|
|
|
GxE term LRtest p = 1.4042e-02
|
|
|
GxE term LRtest p = 4.5596e-04
|
Stratified OR
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
0.91 (0.84-0.99)
|
0.7 (0.46-1.08)
|
0.91 (0.84-0.99)
|
0.7 (0.46-1.08)
|
10452.8/15081.3
|
1372/2079.8
|
45.2/83.8
|
|
p0
|
P= 1
|
P= 0.024
|
P= 0.1
|
P= 0.024
|
P= 0.1
|
|
|
|
|
bmic3f=Overweight
|
1.11 (1.07-1.15)
|
1.1 (1.02-1.18)
|
1.02 (0.69-1.48)
|
0.99 (0.92-1.06)
|
0.92 (0.63-1.34)
|
13552.5/18192.6
|
1841.3/2395
|
64.1/91.4
|
|
p1
|
P= 1.9e-08
|
P= 0.014
|
P= 0.94
|
P= 0.75
|
P= 0.65
|
|
|
|
|
bmic3f=Obese
|
1.32 (1.27-1.38)
|
1.56 (1.41-1.71)
|
2.33 (1.34-4.05)
|
1.17 (1.06-1.3)
|
1.76 (1.01-3.06)
|
7897.4/9352.7
|
1143.3/1143.4
|
46.4/30.9
|
|
p2
|
P= 2.3e-39
|
P= 3.5e-19
|
P= 0.0026
|
P= 0.0016
|
P= 0.045
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.11 (1.07-1.15)
|
1.2 (1.09-1.33)
|
1.45 (0.82-2.56)
|
|
|
|
|
|
|
p1 (G)
|
P= 1.9e-08
|
P= 0.00037
|
P= 0.2
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.32 (1.27-1.38)
|
1.71 (1.51-1.93)
|
3.32 (1.66-6.67)
|
|
|
|
|
|
|
p2 (G)
|
P= 2.3e-39
|
P= 2.2e-18
|
P= 0.00072
|
|
|
|
|
|
Stratified OR (adj smk_ever)
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
0.91 (0.84-0.99)
|
0.7 (0.45-1.07)
|
0.91 (0.84-0.99)
|
0.7 (0.45-1.07)
|
10188.6/14885.9
|
1340.3/2046.3
|
45.1/83.8
|
|
p0
|
P= 1
|
P= 0.033
|
P= 0.099
|
P= 0.033
|
P= 0.099
|
|
|
|
|
bmic3f=Overweight
|
1.11 (1.08-1.16)
|
1.11 (1.03-1.2)
|
1.03 (0.7-1.51)
|
1 (0.93-1.07)
|
0.92 (0.63-1.36)
|
13206.7/17914.7
|
1804.3/2353
|
62/89.3
|
|
p1
|
P= 4.6e-09
|
P= 0.0052
|
P= 0.89
|
P= 0.93
|
P= 0.68
|
|
|
|
|
bmic3f=Obese
|
1.34 (1.28-1.4)
|
1.58 (1.43-1.74)
|
2.31 (1.33-4.02)
|
1.18 (1.06-1.3)
|
1.73 (0.99-3.01)
|
7724/9214
|
1115.5/1121.3
|
45.5/30.7
|
|
p2
|
P= 3.7e-41
|
P= 8.6e-20
|
P= 0.003
|
P= 0.0015
|
P= 0.053
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.11 (1.08-1.16)
|
1.22 (1.1-1.35)
|
1.47 (0.83-2.62)
|
|
|
|
|
|
|
p1 (G)
|
P= 4.6e-09
|
P= 0.00021
|
P= 0.19
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.34 (1.28-1.4)
|
1.72 (1.53-1.95)
|
3.32 (1.65-6.67)
|
|
|
|
|
|
|
p2 (G)
|
P= 3.7e-41
|
P= 1.5e-18
|
P= 0.00077
|
|
|
|
|
|
Locuszoom

Func Annot

chr9_136601110_C_G
Allele freq

GxE model by sex
sex stratified chr9_136601110_C_G_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr9_136601110_C_G_dose
|
0.530*** (0.268, 0.792)
|
0.561*** (0.224, 0.898)
|
0.468*** (0.049, 0.887)
|
|
bmi5
|
1.130*** (1.113, 1.147)
|
1.094*** (1.072, 1.116)
|
1.189*** (1.163, 1.216)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.006*** (1.003, 1.008)
|
1.009*** (1.007, 1.011)
|
|
sex
|
1.110*** (1.079, 1.141)
|
|
|
|
chr9_136601110_C_G_dose:bmi5
|
1.118*** (1.071, 1.166)
|
1.110*** (1.049, 1.171)
|
1.141*** (1.065, 1.216)
|
|
Constant
|
1.433 (1.030, 1.837)
|
0.466*** (0.241, 0.690)
|
1.093 (0.665, 1.522)
|
|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 3.4901e-06
|
|
|
GxE term LRtest p = 8.2985e-04
|
|
|
GxE term LRtest p = 6.1030e-04
|
GxE model by study design
study_design stratified chr9_136601110_C_G_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
|
Case-Control (Ca=20557,Co=19763)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr9_136601110_C_G_dose
|
0.530*** (0.268, 0.792)
|
0.538** (0.159, 0.917)
|
0.521*** (0.156, 0.885)
|
|
bmi5
|
1.130*** (1.113, 1.147)
|
1.130*** (1.105, 1.154)
|
1.129*** (1.105, 1.152)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
|
1.008*** (1.006, 1.010)
|
|
sex
|
1.110*** (1.079, 1.141)
|
1.165*** (1.116, 1.214)
|
1.074*** (1.033, 1.115)
|
|
chr9_136601110_C_G_dose:bmi5
|
1.118*** (1.071, 1.166)
|
1.109** (1.040, 1.177)
|
1.128*** (1.062, 1.194)
|
|
Constant
|
1.433 (1.030, 1.837)
|
1.590* (1.147, 2.033)
|
0.349*** (0.149, 0.549)
|
|
|
|
Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 3.4901e-06
|
|
|
GxE term LRtest p = 3.1123e-03
|
|
|
GxE term LRtest p = 3.2050e-04
|
GxE model by tumor site
cancer_site_sum2 stratified chr9_136601110_C_G_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
|
Distal (Ca=10928,Co=48451)
|
Rectal (Ca=9200,Co=48451)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr9_136601110_C_G_dose
|
0.530*** (0.268, 0.792)
|
0.505*** (0.098, 0.912)
|
0.511*** (0.117, 0.905)
|
0.719 (0.276, 1.162)
|
|
bmi5
|
1.130*** (1.113, 1.147)
|
1.180*** (1.153, 1.206)
|
1.133*** (1.107, 1.158)
|
1.084*** (1.056, 1.113)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
0.997* (0.995, 1.000)
|
1.020*** (1.017, 1.022)
|
0.992*** (0.989, 0.994)
|
|
sex
|
1.110*** (1.079, 1.141)
|
1.060* (1.010, 1.110)
|
0.844*** (0.795, 0.892)
|
1.300*** (1.249, 1.351)
|
|
chr9_136601110_C_G_dose:bmi5
|
1.118*** (1.071, 1.166)
|
1.131*** (1.059, 1.204)
|
1.125** (1.054, 1.196)
|
1.063 (0.983, 1.144)
|
|
Constant
|
1.433 (1.030, 1.837)
|
0.488** (-0.040, 1.016)
|
0.216*** (-0.303, 0.735)
|
1.899** (1.434, 2.365)
|
|
|
|
Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 3.4901e-06
|
|
|
GxE term LRtest p = 8.8246e-04
|
|
|
GxE term LRtest p = 1.1910e-03
|
|
|
GxE term LRtest p = 1.3749e-01
|
Stratified OR
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
CC
|
CG
|
GG
|
CG
|
GG
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
0.86 (0.79-0.94)
|
0.62 (0.42-0.93)
|
0.86 (0.79-0.94)
|
0.62 (0.42-0.93)
|
10340.4/14811.9
|
1474/2328.3
|
55.7/104.7
|
|
p0
|
P= 1
|
P= 0.00045
|
P= 0.022
|
P= 0.00045
|
P= 0.022
|
|
|
|
|
bmic3f=Overweight
|
1.1 (1.06-1.14)
|
1.1 (1.02-1.18)
|
1.01 (0.69-1.48)
|
1 (0.93-1.08)
|
0.92 (0.63-1.35)
|
13350.1/17911.5
|
2035.3/2661.1
|
72.6/106.4
|
|
p1
|
P= 7.1e-07
|
P= 0.011
|
P= 0.96
|
P= 0.95
|
P= 0.67
|
|
|
|
|
bmic3f=Obese
|
1.31 (1.26-1.37)
|
1.53 (1.38-1.68)
|
1.46 (0.88-2.44)
|
1.16 (1.05-1.28)
|
1.11 (0.67-1.85)
|
7802.8/9196
|
1233.7/1274.8
|
50.5/56.2
|
|
p2
|
P= 3.3e-36
|
P= 1.4e-17
|
P= 0.15
|
P= 0.0038
|
P= 0.68
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.1 (1.06-1.14)
|
1.27 (1.15-1.41)
|
1.61 (0.93-2.82)
|
|
|
|
|
|
|
p1 (G)
|
P= 7.1e-07
|
P= 3.3e-06
|
P= 0.092
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.31 (1.26-1.37)
|
1.77 (1.57-2)
|
2.34 (1.22-4.48)
|
|
|
|
|
|
|
p2 (G)
|
P= 3.3e-36
|
P= 1.6e-20
|
P= 0.01
|
|
|
|
|
|
Stratified OR (adj smk_ever)
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
CC
|
CG
|
GG
|
CG
|
GG
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
0.86 (0.8-0.94)
|
0.62 (0.41-0.93)
|
0.86 (0.8-0.94)
|
0.62 (0.41-0.93)
|
10084.6/14620.4
|
1435.3/2292.5
|
54.1/103.1
|
|
p0
|
P= 1
|
P= 0.00063
|
P= 0.022
|
P= 0.00063
|
P= 0.022
|
|
|
|
|
bmic3f=Overweight
|
1.1 (1.06-1.15)
|
1.1 (1.03-1.19)
|
1.01 (0.69-1.5)
|
1 (0.93-1.08)
|
0.92 (0.62-1.36)
|
13015/17630
|
1986.9/2621.6
|
71.1/105.4
|
|
p1
|
P= 1.4e-07
|
P= 0.0086
|
P= 0.94
|
P= 1
|
P= 0.67
|
|
|
|
|
bmic3f=Obese
|
1.33 (1.27-1.38)
|
1.55 (1.41-1.71)
|
1.5 (0.9-2.5)
|
1.17 (1.06-1.3)
|
1.13 (0.68-1.88)
|
7625.8/9058.9
|
1208.9/1250.9
|
50.3/56.1
|
|
p2
|
P= 1.3e-37
|
P= 1.4e-18
|
P= 0.12
|
P= 0.0023
|
P= 0.64
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.1 (1.06-1.15)
|
1.28 (1.15-1.42)
|
1.63 (0.93-2.87)
|
|
|
|
|
|
|
p1 (G)
|
P= 1.4e-07
|
P= 3.4e-06
|
P= 0.088
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.33 (1.27-1.38)
|
1.8 (1.59-2.03)
|
2.41 (1.25-4.63)
|
|
|
|
|
|
|
p2 (G)
|
P= 1.3e-37
|
P= 3.7e-21
|
P= 0.0084
|
|
|
|
|
|
Locuszoom

Func Annot

Two-step findings
chr15_33120215_T_C
Allele freq

GxE model by sex
sex stratified chr15_33120215_T_C_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr15_33120215_T_C_dose
|
1.497*** (1.349, 1.646)
|
1.509*** (1.317, 1.702)
|
1.466** (1.231, 1.702)
|
|
bmi5
|
1.178*** (1.159, 1.197)
|
1.138*** (1.114, 1.163)
|
1.241*** (1.211, 1.272)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.006*** (1.003, 1.008)
|
1.009*** (1.007, 1.011)
|
|
sex
|
1.110*** (1.078, 1.141)
|
|
|
|
chr15_33120215_T_C_dose:bmi5
|
0.940*** (0.913, 0.966)
|
0.940*** (0.905, 0.975)
|
0.942** (0.900, 0.985)
|
|
Constant
|
1.117 (0.710, 1.524)
|
0.361*** (0.128, 0.594)
|
0.847 (0.411, 1.284)
|
|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 5.2723e-06
|
|
|
GxE term LRtest p = 5.1191e-04
|
|
|
GxE term LRtest p = 6.1458e-03
|
GxE model by study design
study_design stratified chr15_33120215_T_C_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
|
Case-Control (Ca=20557,Co=19763)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr15_33120215_T_C_dose
|
1.497*** (1.349, 1.646)
|
1.574*** (1.359, 1.789)
|
1.429*** (1.224, 1.634)
|
|
bmi5
|
1.178*** (1.159, 1.197)
|
1.179*** (1.151, 1.207)
|
1.175*** (1.149, 1.201)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
|
1.008*** (1.006, 1.010)
|
|
sex
|
1.110*** (1.078, 1.141)
|
1.165*** (1.116, 1.214)
|
1.073*** (1.032, 1.114)
|
|
chr15_33120215_T_C_dose:bmi5
|
0.940*** (0.913, 0.966)
|
0.933*** (0.894, 0.972)
|
0.946** (0.909, 0.983)
|
|
Constant
|
1.117 (0.710, 1.524)
|
1.219 (0.770, 1.668)
|
0.274*** (0.063, 0.484)
|
|
|
|
Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 5.2723e-06
|
|
|
GxE term LRtest p = 4.8718e-04
|
|
|
GxE term LRtest p = 3.0959e-03
|
GxE model by tumor site
cancer_site_sum2 stratified chr15_33120215_T_C_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
|
Distal (Ca=10928,Co=48451)
|
Rectal (Ca=9200,Co=48451)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr15_33120215_T_C_dose
|
1.497*** (1.349, 1.646)
|
1.570*** (1.337, 1.804)
|
1.533*** (1.310, 1.756)
|
1.521*** (1.273, 1.769)
|
|
bmi5
|
1.178*** (1.159, 1.197)
|
1.238*** (1.209, 1.268)
|
1.184*** (1.155, 1.212)
|
1.122*** (1.090, 1.154)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
0.997* (0.995, 1.000)
|
1.020*** (1.017, 1.022)
|
0.992*** (0.989, 0.994)
|
|
sex
|
1.110*** (1.078, 1.141)
|
1.059* (1.009, 1.109)
|
0.843*** (0.794, 0.891)
|
1.299*** (1.248, 1.350)
|
|
chr15_33120215_T_C_dose:bmi5
|
0.940*** (0.913, 0.966)
|
0.928*** (0.886, 0.970)
|
0.935** (0.894, 0.975)
|
0.940** (0.895, 0.985)
|
|
Constant
|
1.117 (0.710, 1.524)
|
0.368*** (-0.166, 0.901)
|
0.165*** (-0.359, 0.690)
|
1.544 (1.072, 2.017)
|
|
|
|
Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 5.2723e-06
|
|
|
GxE term LRtest p = 4.2147e-04
|
|
|
GxE term LRtest p = 9.8524e-04
|
|
|
GxE term LRtest p = 6.8539e-03
|
Stratified OR
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
TT
|
TC
|
CC
|
TC
|
CC
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.12 (1.06-1.18)
|
1.26 (1.12-1.43)
|
1.12 (1.06-1.18)
|
1.26 (1.12-1.43)
|
7377.6/11093.1
|
3945.3/5466.8
|
547.1/685.2
|
|
p0
|
P= 1
|
P= 4.5e-05
|
P= 0.00017
|
P= 4.5e-05
|
P= 0.00017
|
|
|
|
|
bmic3f=Overweight
|
1.13 (1.09-1.18)
|
1.24 (1.18-1.31)
|
1.28 (1.14-1.43)
|
1.1 (1.05-1.15)
|
1.13 (1.01-1.26)
|
9679.6/13323.4
|
5112.1/6527.7
|
666.4/827.9
|
|
p1
|
P= 5.7e-09
|
P= 7.8e-18
|
P= 1.7e-05
|
P= 9.7e-05
|
P= 0.031
|
|
|
|
|
bmic3f=Obese
|
1.45 (1.38-1.52)
|
1.42 (1.34-1.51)
|
1.27 (1.09-1.47)
|
0.98 (0.92-1.05)
|
0.87 (0.75-1.02)
|
5818.6/6629.1
|
2916.2/3432.6
|
352.2/465.3
|
|
p2
|
P= 1.9e-50
|
P= 7.2e-30
|
P= 0.0019
|
P= 0.57
|
P= 0.079
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.13 (1.09-1.18)
|
1.11 (1.05-1.18)
|
1.01 (0.86-1.19)
|
|
|
|
|
|
|
p1 (G)
|
P= 5.7e-09
|
P= 0.00026
|
P= 0.88
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.45 (1.38-1.52)
|
1.28 (1.19-1.37)
|
1 (0.83-1.21)
|
|
|
|
|
|
|
p2 (G)
|
P= 1.9e-50
|
P= 2.3e-12
|
P= 0.98
|
|
|
|
|
|
Stratified OR (adj smk_ever)
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
TT
|
TC
|
CC
|
TC
|
CC
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.11 (1.06-1.17)
|
1.28 (1.13-1.45)
|
1.11 (1.06-1.17)
|
1.28 (1.13-1.45)
|
7192.5/10942.2
|
3840.6/5398.7
|
541/675.2
|
|
p0
|
P= 1
|
P= 8.5e-05
|
P= 7.7e-05
|
P= 8.5e-05
|
P= 7.7e-05
|
|
|
|
|
bmic3f=Overweight
|
1.14 (1.09-1.19)
|
1.25 (1.19-1.31)
|
1.28 (1.15-1.44)
|
1.1 (1.04-1.15)
|
1.13 (1.01-1.26)
|
9441.7/13108.8
|
4986/6435.1
|
645.4/813.1
|
|
p1
|
P= 1.2e-09
|
P= 4.1e-18
|
P= 1.7e-05
|
P= 0.00018
|
P= 0.039
|
|
|
|
|
bmic3f=Obese
|
1.46 (1.39-1.54)
|
1.44 (1.35-1.53)
|
1.29 (1.11-1.5)
|
0.99 (0.92-1.05)
|
0.88 (0.76-1.03)
|
5685.6/6537
|
2854.2/3372.6
|
345.2/456.3
|
|
p2
|
P= 2.1e-51
|
P= 4.6e-31
|
P= 0.00096
|
P= 0.65
|
P= 0.11
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.14 (1.09-1.19)
|
1.12 (1.06-1.19)
|
1 (0.85-1.18)
|
|
|
|
|
|
|
p1 (G)
|
P= 1.2e-09
|
P= 0.00012
|
P= 0.99
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.46 (1.39-1.54)
|
1.29 (1.21-1.39)
|
1.01 (0.83-1.22)
|
|
|
|
|
|
|
p2 (G)
|
P= 2.1e-51
|
P= 2.1e-13
|
P= 0.95
|
|
|
|
|
|
Locuszoom

Func Annot

chr15_33122966_C_T
Allele freq

GxE model by sex
sex stratified chr15_33122966_C_T_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Female (Ca=17139,Co=23717)
|
Male (Ca=19276,Co=24734)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr15_33122966_C_T_dose
|
1.501*** (1.352, 1.649)
|
1.521*** (1.329, 1.713)
|
1.456** (1.220, 1.691)
|
|
bmi5
|
1.178*** (1.159, 1.197)
|
1.139*** (1.114, 1.164)
|
1.240*** (1.210, 1.271)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.006*** (1.003, 1.008)
|
1.009*** (1.007, 1.011)
|
|
sex
|
1.110*** (1.078, 1.141)
|
|
|
|
chr15_33122966_C_T_dose:bmi5
|
0.939*** (0.913, 0.966)
|
0.939*** (0.904, 0.974)
|
0.944** (0.902, 0.987)
|
|
Constant
|
1.116 (0.709, 1.523)
|
0.360*** (0.127, 0.593)
|
0.850 (0.414, 1.287)
|
|
|
|
Observations
|
84,866
|
40,856
|
44,010
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 4.9681e-06
|
|
|
GxE term LRtest p = 3.7163e-04
|
|
|
GxE term LRtest p = 7.9671e-03
|
GxE model by study design
study_design stratified chr15_33122966_C_T_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Cohort (Ca=15858,Co=28688)
|
Case-Control (Ca=20557,Co=19763)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr15_33122966_C_T_dose
|
1.501*** (1.352, 1.649)
|
1.584*** (1.369, 1.799)
|
1.427*** (1.222, 1.632)
|
|
bmi5
|
1.178*** (1.159, 1.197)
|
1.180*** (1.152, 1.208)
|
1.175*** (1.149, 1.201)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
1.005*** (1.002, 1.008)
|
1.008*** (1.006, 1.010)
|
|
sex
|
1.110*** (1.078, 1.141)
|
1.165*** (1.116, 1.214)
|
1.073*** (1.032, 1.114)
|
|
chr15_33122966_C_T_dose:bmi5
|
0.939*** (0.913, 0.966)
|
0.932*** (0.893, 0.971)
|
0.946** (0.909, 0.983)
|
|
Constant
|
1.116 (0.709, 1.523)
|
1.215 (0.766, 1.665)
|
0.274*** (0.064, 0.484)
|
|
|
|
Observations
|
84,866
|
44,546
|
40,320
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 4.9681e-06
|
|
|
GxE term LRtest p = 4.0843e-04
|
|
|
GxE term LRtest p = 3.3760e-03
|
GxE model by tumor site
cancer_site_sum2 stratified chr15_33122966_C_T_dose x bmi5
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=36415,Co=48451)
|
Proximal (Ca=9398,Co=48451)
|
Distal (Ca=10928,Co=48451)
|
Rectal (Ca=9200,Co=48451)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr15_33122966_C_T_dose
|
1.501*** (1.352, 1.649)
|
1.548*** (1.315, 1.782)
|
1.528*** (1.304, 1.751)
|
1.562*** (1.314, 1.810)
|
|
bmi5
|
1.178*** (1.159, 1.197)
|
1.237*** (1.207, 1.266)
|
1.183*** (1.155, 1.212)
|
1.124*** (1.092, 1.156)
|
|
age_ref_imp
|
1.007*** (1.006, 1.009)
|
0.997* (0.995, 1.000)
|
1.020*** (1.017, 1.022)
|
0.992*** (0.989, 0.994)
|
|
sex
|
1.110*** (1.078, 1.141)
|
1.059* (1.009, 1.109)
|
0.843*** (0.794, 0.891)
|
1.299*** (1.248, 1.350)
|
|
chr15_33122966_C_T_dose:bmi5
|
0.939*** (0.913, 0.966)
|
0.931*** (0.889, 0.973)
|
0.935** (0.895, 0.975)
|
0.936** (0.891, 0.981)
|
|
Constant
|
1.116 (0.709, 1.523)
|
0.370*** (-0.164, 0.903)
|
0.165*** (-0.359, 0.690)
|
1.528 (1.056, 2.001)
|
|
|
|
Observations
|
84,866
|
57,849
|
59,379
|
57,651
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 4.9681e-06
|
|
|
GxE term LRtest p = 7.3858e-04
|
|
|
GxE term LRtest p = 1.0582e-03
|
|
|
GxE term LRtest p = 3.8049e-03
|
Stratified OR
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.12 (1.06-1.18)
|
1.26 (1.12-1.43)
|
1.12 (1.06-1.18)
|
1.26 (1.12-1.43)
|
7382/11094.8
|
3938.6/5459
|
549.5/691.3
|
|
p0
|
P= 1
|
P= 4.3e-05
|
P= 0.0002
|
P= 4.3e-05
|
P= 0.0002
|
|
|
|
|
bmic3f=Overweight
|
1.13 (1.08-1.18)
|
1.25 (1.19-1.31)
|
1.28 (1.14-1.43)
|
1.1 (1.05-1.16)
|
1.13 (1.01-1.27)
|
9678.1/13327.5
|
5114.5/6524.9
|
665.5/826.6
|
|
p1
|
P= 7.7e-09
|
P= 4e-18
|
P= 1.7e-05
|
P= 5.8e-05
|
P= 0.029
|
|
|
|
|
bmic3f=Obese
|
1.45 (1.38-1.52)
|
1.43 (1.34-1.52)
|
1.26 (1.09-1.47)
|
0.99 (0.92-1.05)
|
0.87 (0.75-1.02)
|
5812.3/6625.6
|
2924.4/3436.3
|
350.2/465.1
|
|
p2
|
P= 3.9e-50
|
P= 2.9e-30
|
P= 0.0022
|
P= 0.65
|
P= 0.077
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.13 (1.08-1.18)
|
1.12 (1.05-1.18)
|
1.02 (0.86-1.19)
|
|
|
|
|
|
|
p1 (G)
|
P= 7.7e-09
|
P= 0.00021
|
P= 0.85
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.45 (1.38-1.52)
|
1.28 (1.19-1.37)
|
1 (0.83-1.21)
|
|
|
|
|
|
|
p2 (G)
|
P= 3.9e-50
|
P= 1.5e-12
|
P= 0.98
|
|
|
|
|
|
Stratified OR (adj smk_ever)
|
|
G param by E
|
Counts (Ca/Co)
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
N0
|
N1
|
N2
|
|
bmic3f=Normal
|
1
|
1.11 (1.06-1.18)
|
1.28 (1.13-1.45)
|
1.11 (1.06-1.18)
|
1.28 (1.13-1.45)
|
7196.4/10942.9
|
3834.3/5391.8
|
543.3/681.3
|
|
p0
|
P= 1
|
P= 8.5e-05
|
P= 8.9e-05
|
P= 8.5e-05
|
P= 8.9e-05
|
|
|
|
|
bmic3f=Overweight
|
1.14 (1.09-1.19)
|
1.25 (1.19-1.32)
|
1.28 (1.15-1.44)
|
1.1 (1.05-1.15)
|
1.13 (1.01-1.26)
|
9441.2/13112.5
|
4987.3/6432.6
|
644.5/811.9
|
|
p1
|
P= 1.5e-09
|
P= 2.4e-18
|
P= 1.7e-05
|
P= 0.00012
|
P= 0.038
|
|
|
|
|
bmic3f=Obese
|
1.46 (1.39-1.54)
|
1.44 (1.36-1.54)
|
1.29 (1.11-1.5)
|
0.99 (0.93-1.05)
|
0.88 (0.76-1.03)
|
5680.3/6533.6
|
2860.4/3376.3
|
344.2/456.1
|
|
p2
|
P= 4.2e-51
|
P= 2.4e-31
|
P= 0.00098
|
P= 0.72
|
P= 0.11
|
|
|
|
|
E param by G
|
|
bmic3f=Overweight(G)
|
1.14 (1.09-1.19)
|
1.12 (1.06-1.19)
|
1 (0.85-1.18)
|
|
|
|
|
|
|
p1 (G)
|
P= 1.5e-09
|
P= 9.6e-05
|
P= 0.96
|
|
|
|
|
|
|
bmic3f=Obese(G)
|
1.46 (1.39-1.54)
|
1.3 (1.21-1.39)
|
1.01 (0.83-1.22)
|
|
|
|
|
|
|
p2 (G)
|
P= 4.2e-51
|
P= 1.5e-13
|
P= 0.93
|
|
|
|
|
|
Locuszoom

Func Annot

3DF findings
All SNPs associated with BMI, no evidence of GxE (pvalue > 0.05), very small evidence of main effects
chr1_177889480_A_G
Locuszoom

Func Annot

chr12_50204089_G_A
Locuszoom

Func Annot

chr16_28649651_C_A
Locuszoom

Func Annot

chr16_53800954_T_C
Locuszoom

Func Annot

chr18_57850583_C_A
Locuszoom

Func Annot

chr18_57971625_A_G
Locuszoom

Func Annot

chr18_58083923_A_C
Locuszoom

Func Annot

chr19_47581242_C_T
Locuszoom

Func Annot

chr2_417167_T_C
Locuszoom

Func Annot

chr2_558080_G_T
Locuszoom

Func Annot

chr2_651365_G_A
Locuszoom

Func Annot

chr4_45181334_A_T
Locuszoom

Func Annot
