Description

Follow-up analyses of GWIS findings

  • Table of significant and suggestive (1df GxE only) bmi5 GWIS findings
  • GxE models stratified by study_design and tumor site (proximal, distal, rectal)
  • GxE models with additional covariate sets (might do this for aspirin ..)
  • Odds ratios stratified by exposure and genotype
  • Plots of model predicted outcome by 1 unit increase of exposure/allelic dosage
  • Locuszoom plot
  • Functional annotation plot

Suggestive GxE findings

chr11_120531547_C_G

Allele freq

GxE model by sex

sex stratified chr11_120531547_C_G_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr11_120531547_C_G_dose 0.726*** (0.597, 0.854) 0.726*** (0.558, 0.893) 0.710*** (0.508, 0.912)
bmi5 1.068*** (1.035, 1.101) 1.026 (0.983, 1.069) 1.129*** (1.077, 1.181)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.003, 1.008) 1.009*** (1.007, 1.011)
sex 1.110*** (1.079, 1.141)
chr11_120531547_C_G_dose:bmi5 1.058*** (1.035, 1.082) 1.064*** (1.034, 1.095) 1.057** (1.021, 1.094)
Constant 1.963** (1.529, 2.396) 0.643** (0.338, 0.947) 1.519 (1.024, 2.014)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.6055e-06
GxE term LRtest p = 5.5872e-05
GxE term LRtest p = 2.6517e-03

GxE model by study design

study_design stratified chr11_120531547_C_G_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr11_120531547_C_G_dose 0.726*** (0.597, 0.854) 0.735** (0.548, 0.921) 0.717*** (0.539, 0.894)
bmi5 1.068*** (1.035, 1.101) 1.067** (1.018, 1.116) 1.068** (1.023, 1.114)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.110*** (1.079, 1.141) 1.165*** (1.116, 1.214) 1.074*** (1.033, 1.114)
chr11_120531547_C_G_dose:bmi5 1.058*** (1.035, 1.082) 1.057** (1.024, 1.091) 1.060*** (1.028, 1.092)
Constant 1.963** (1.529, 2.396) 2.160** (1.661, 2.658) 0.482*** (0.187, 0.777)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.6055e-06
GxE term LRtest p = 1.2021e-03
GxE term LRtest p = 3.8706e-04

GxE model by tumor site

cancer_site_sum2 stratified chr11_120531547_C_G_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr11_120531547_C_G_dose 0.726*** (0.597, 0.854) 0.745** (0.543, 0.947) 0.804* (0.610, 0.999) 0.712** (0.496, 0.929)
bmi5 1.068*** (1.035, 1.101) 1.129*** (1.077, 1.181) 1.093*** (1.042, 1.143) 1.011 (0.954, 1.068)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.020*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.110*** (1.079, 1.141) 1.060* (1.010, 1.109) 0.843*** (0.795, 0.892) 1.301*** (1.250, 1.352)
chr11_120531547_C_G_dose:bmi5 1.058*** (1.035, 1.082) 1.050** (1.014, 1.086) 1.042* (1.007, 1.077) 1.064** (1.025, 1.103)
Constant 1.963** (1.529, 2.396) 0.637 (0.054, 1.219) 0.259*** (-0.311, 0.830) 2.796*** (2.258, 3.333)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.6055e-06
GxE term LRtest p = 7.8067e-03
GxE term LRtest p = 2.0831e-02
GxE term LRtest p = 1.9867e-03

Stratified OR

G param by E
Counts (Ca/Co)
CC CG GG CG GG N0 N1 N2
bmic3f=Normal 1 0.98 (0.91-1.07) 0.9 (0.83-0.98) 0.98 (0.91-1.07) 0.9 (0.83-0.98) 1652.3/2267.7 5495.9/7743.9 4721.8/7233.4
p0 P= 1 P= 0.71 P= 0.013 P= 0.71 P= 0.013
bmic3f=Overweight 1.08 (0.98-1.18) 1.08 (1-1.17) 1.05 (0.97-1.13) 1.01 (0.94-1.08) 0.98 (0.91-1.05) 2087.8/2748.9 7202/9570.1 6168.2/8360
p1 P= 0.13 P= 0.046 P= 0.24 P= 0.86 P= 0.5
bmic3f=Obese 1.21 (1.09-1.36) 1.26 (1.16-1.37) 1.39 (1.28-1.51) 1.04 (0.94-1.15) 1.14 (1.04-1.26) 1201.6/1461.8 4099.9/4896.2 3785.5/4169
p2 P= 0.00057 P= 4.8e-08 P= 3.5e-14 P= 0.44 P= 0.0069
E param by G
bmic3f=Overweight(G) 1.08 (0.98-1.18) 1.1 (1.04-1.16) 1.16 (1.1-1.22)
p1 (G) P= 0.13 P= 0.00027 P= 4.9e-08
bmic3f=Obese(G) 1.21 (1.09-1.36) 1.28 (1.21-1.36) 1.54 (1.44-1.64)
p2 (G) P= 0.00057 P= 3e-16 P= 1.9e-41

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
CC CG GG CG GG N0 N1 N2
bmic3f=Normal 1 0.99 (0.91-1.08) 0.92 (0.84-0.99) 0.99 (0.91-1.08) 0.92 (0.84-0.99) 1605.6/2244.1 5352.5/7642.9 4615.9/7129
p0 P= 1 P= 0.82 P= 0.033 P= 0.82 P= 0.033
bmic3f=Overweight 1.09 (1-1.2) 1.1 (1.01-1.18) 1.07 (0.98-1.15) 1 (0.93-1.08) 0.97 (0.9-1.05) 2038.5/2700.5 7011.7/9430.8 6022.7/8225.7
p1 P= 0.063 P= 0.024 P= 0.12 P= 0.99 P= 0.47
bmic3f=Obese 1.24 (1.1-1.38) 1.29 (1.19-1.4) 1.41 (1.29-1.53) 1.04 (0.95-1.15) 1.14 (1.03-1.26) 1171/1437.4 4007.8/4813.2 3706.2/4115.4
p2 P= 0.00021 P= 3.8e-09 P= 6.8e-15 P= 0.39 P= 0.0097
E param by G
bmic3f=Overweight(G) 1.09 (1-1.2) 1.11 (1.05-1.16) 1.16 (1.1-1.23)
p1 (G) P= 0.063 P= 0.00013 P= 3.6e-08
bmic3f=Obese(G) 1.24 (1.1-1.38) 1.3 (1.23-1.38) 1.54 (1.44-1.64)
p2 (G) P= 0.00021 P= 9.2e-18 P= 1.2e-40

Locuszoom

Func Annot

chr11_46574459_T_A

Allele freq

GxE model by sex

sex stratified chr11_46574459_T_A_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr11_46574459_T_A_dose 0.509*** (0.218, 0.800) 0.466*** (0.084, 0.847) 0.596* (0.142, 1.049)
bmi5 1.133*** (1.117, 1.150) 1.094*** (1.073, 1.115) 1.199*** (1.173, 1.225)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.004, 1.008) 1.009*** (1.007, 1.011)
sex 1.111*** (1.079, 1.142)
chr11_46574459_T_A_dose:bmi5 1.136*** (1.083, 1.188) 1.159*** (1.090, 1.228) 1.101* (1.019, 1.183)
Constant 1.403 (1.000, 1.806) 0.461*** (0.238, 0.683) 1.043 (0.616, 1.471)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.9279e-06
GxE term LRtest p = 2.4866e-05
GxE term LRtest p = 2.1045e-02

GxE model by study design

study_design stratified chr11_46574459_T_A_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr11_46574459_T_A_dose 0.509*** (0.218, 0.800) 0.559* (0.103, 1.015) 0.478*** (0.096, 0.860)
bmi5 1.133*** (1.117, 1.150) 1.135*** (1.112, 1.159) 1.130*** (1.108, 1.153)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.111*** (1.079, 1.142) 1.165*** (1.116, 1.214) 1.075*** (1.034, 1.116)
chr11_46574459_T_A_dose:bmi5 1.136*** (1.083, 1.188) 1.107* (1.024, 1.190) 1.156*** (1.087, 1.225)
Constant 1.403 (1.000, 1.806) 1.537 (1.096, 1.979) 0.344*** (0.147, 0.541)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.9279e-06
GxE term LRtest p = 1.5750e-02
GxE term LRtest p = 3.3168e-05

GxE model by tumor site

cancer_site_sum2 stratified chr11_46574459_T_A_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr11_46574459_T_A_dose 0.509*** (0.218, 0.800) 0.583* (0.127, 1.039) 0.509** (0.074, 0.943) 0.383*** (-0.079, 0.844)
bmi5 1.133*** (1.117, 1.150) 1.189*** (1.164, 1.215) 1.137*** (1.112, 1.161) 1.071*** (1.043, 1.099)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.020*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.111*** (1.079, 1.142) 1.060* (1.010, 1.109) 0.844*** (0.795, 0.892) 1.301*** (1.250, 1.352)
chr11_46574459_T_A_dose:bmi5 1.136*** (1.083, 1.188) 1.106* (1.024, 1.187) 1.136** (1.058, 1.214) 1.211*** (1.128, 1.294)
Constant 1.403 (1.000, 1.806) 0.467** (-0.060, 0.993) 0.211*** (-0.307, 0.728) 2.019** (1.554, 2.483)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.9279e-06
GxE term LRtest p = 1.6093e-02
GxE term LRtest p = 1.3937e-03
GxE term LRtest p = 6.2685e-06

Stratified OR

G param by E
Counts (Ca/Co)
TT TA AA TA AA N0 N1 N2
bmic3f=Normal 1 0.84 (0.77-0.92) 1.22 (0.77-1.94) 0.84 (0.77-0.92) 1.22 (0.77-1.94) 10767.5/15529.1 1057.7/1664.1 44.8/51.8
p0 P= 1 P= 0.00012 P= 0.4 P= 0.00012 P= 0.4
bmic3f=Overweight 1.1 (1.06-1.14) 1.15 (1.06-1.24) 1.69 (1.11-2.6) 1.05 (0.97-1.13) 1.55 (1.01-2.37) 13870.9/18768 1524.5/1858.6 62.6/52.3
p1 P= 3.6e-07 P= 0.00081 P= 0.016 P= 0.26 P= 0.046
bmic3f=Obese 1.33 (1.27-1.38) 1.53 (1.37-1.7) 2.19 (1.24-3.86) 1.15 (1.03-1.28) 1.65 (0.93-2.91) 8114.1/9600.4 932/900 40.9/26.6
p2 P= 4.1e-41 P= 5.9e-15 P= 0.007 P= 0.011 P= 0.086
E param by G
bmic3f=Overweight(G) 1.1 (1.06-1.14) 1.37 (1.22-1.54) 1.39 (0.74-2.61)
p1 (G) P= 3.6e-07 P= 6e-08 P= 0.31
bmic3f=Obese(G) 1.33 (1.27-1.38) 1.83 (1.6-2.09) 1.79 (0.86-3.73)
p2 (G) P= 4.1e-41 P= 1e-18 P= 0.12

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
TT TA AA TA AA N0 N1 N2
bmic3f=Normal 1 0.84 (0.77-0.93) 1.25 (0.79-1.99) 0.84 (0.77-0.93) 1.25 (0.79-1.99) 10495.2/15328.6 1034/1635.6 44.8/51.8
p0 P= 1 P= 0.00028 P= 0.35 P= 0.00028 P= 0.35
bmic3f=Overweight 1.1 (1.07-1.14) 1.16 (1.07-1.25) 1.7 (1.11-2.6) 1.05 (0.97-1.14) 1.54 (1-2.36) 13512/18464.8 1498.5/1839.8 62.5/52.3
p1 P= 6.1e-08 P= 0.00044 P= 0.015 P= 0.26 P= 0.048
bmic3f=Obese 1.34 (1.29-1.4) 1.55 (1.39-1.73) 2.37 (1.33-4.22) 1.16 (1.04-1.29) 1.77 (0.99-3.15) 7927.7/9456.5 916.5/883.8 40.8/25.7
p2 P= 6.3e-43 P= 1.2e-15 P= 0.0033 P= 0.0094 P= 0.053
E param by G
bmic3f=Overweight(G) 1.1 (1.07-1.14) 1.37 (1.22-1.54) 1.36 (0.72-2.55)
p1 (G) P= 6.1e-08 P= 8.1e-08 P= 0.34
bmic3f=Obese(G) 1.34 (1.29-1.4) 1.84 (1.61-2.1) 1.9 (0.91-3.97)
p2 (G) P= 6.3e-43 P= 9.3e-19 P= 0.089

Locuszoom

Func Annot

chr11_47328213_T_C

Allele freq

GxE model by sex

sex stratified chr11_47328213_T_C_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr11_47328213_T_C_dose 0.425*** (0.088, 0.762) 0.339*** (-0.109, 0.786) 0.594* (0.076, 1.112)
bmi5 1.135*** (1.118, 1.151) 1.094*** (1.073, 1.115) 1.202*** (1.177, 1.228)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.003, 1.008) 1.009*** (1.007, 1.011)
sex 1.110*** (1.079, 1.142)
chr11_47328213_T_C_dose:bmi5 1.173*** (1.112, 1.235) 1.228*** (1.147, 1.310) 1.101* (1.007, 1.195)
Constant 1.397 (0.994, 1.800) 0.461*** (0.240, 0.683) 1.031 (0.604, 1.458)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 2.4160e-07
GxE term LRtest p = 5.2529e-07
GxE term LRtest p = 4.3252e-02

GxE model by study design

study_design stratified chr11_47328213_T_C_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr11_47328213_T_C_dose 0.425*** (0.088, 0.762) 0.427** (-0.107, 0.962) 0.423*** (-0.013, 0.860)
bmi5 1.135*** (1.118, 1.151) 1.135*** (1.111, 1.158) 1.133*** (1.111, 1.156)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.110*** (1.079, 1.142) 1.165*** (1.116, 1.214) 1.074*** (1.033, 1.115)
chr11_47328213_T_C_dose:bmi5 1.173*** (1.112, 1.235) 1.169** (1.072, 1.266) 1.176*** (1.097, 1.255)
Constant 1.397 (0.994, 1.800) 1.541 (1.099, 1.982) 0.341*** (0.145, 0.537)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 2.4160e-07
GxE term LRtest p = 1.5831e-03
GxE term LRtest p = 4.7385e-05

GxE model by tumor site

cancer_site_sum2 stratified chr11_47328213_T_C_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr11_47328213_T_C_dose 0.425*** (0.088, 0.762) 0.425** (-0.103, 0.954) 0.345*** (-0.157, 0.846) 0.457** (-0.083, 0.997)
bmi5 1.135*** (1.118, 1.151) 1.187*** (1.162, 1.213) 1.134*** (1.110, 1.159) 1.081*** (1.054, 1.108)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.020*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.110*** (1.079, 1.142) 1.059* (1.009, 1.109) 0.844*** (0.795, 0.892) 1.300*** (1.250, 1.351)
chr11_47328213_T_C_dose:bmi5 1.173*** (1.112, 1.235) 1.173*** (1.079, 1.268) 1.223*** (1.133, 1.313) 1.162** (1.064, 1.259)
Constant 1.397 (0.994, 1.800) 0.470** (-0.055, 0.996) 0.213*** (-0.304, 0.730) 1.930** (1.466, 2.393)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 2.4160e-07
GxE term LRtest p = 9.2266e-04
GxE term LRtest p = 1.1511e-05
GxE term LRtest p = 2.6590e-03

Stratified OR

G param by E
Counts (Ca/Co)
TT TC CC TC CC N0 N1 N2
bmic3f=Normal 1 0.85 (0.77-0.94) 1.02 (0.57-1.85) 0.85 (0.77-0.94) 1.02 (0.57-1.85) 11020.6/15925.1 823.3/1287.6 26.1/32.4
p0 P= 1 P= 0.0018 P= 0.93 P= 0.0018 P= 0.93
bmic3f=Overweight 1.1 (1.07-1.14) 1.16 (1.06-1.27) 1.4 (0.79-2.47) 1.05 (0.96-1.15) 1.26 (0.72-2.24) 14270/19265.8 1155.4/1382.4 32.6/30.8
p1 P= 3.3e-08 P= 0.0017 P= 0.25 P= 0.31 P= 0.42
bmic3f=Obese 1.34 (1.28-1.39) 1.62 (1.44-1.83) 1.37 (0.66-2.85) 1.22 (1.07-1.38) 1.03 (0.5-2.13) 8356.6/9859.6 710/649.3 20.4/18.1
p2 P= 5.9e-44 P= 7.7e-15 P= 0.39 P= 0.0021 P= 0.94
E param by G
bmic3f=Overweight(G) 1.1 (1.07-1.14) 1.36 (1.19-1.55) 1.36 (0.6-3.09)
p1 (G) P= 3.3e-08 P= 3.6e-06 P= 0.46
bmic3f=Obese(G) 1.34 (1.28-1.39) 1.91 (1.64-2.22) 1.34 (0.53-3.42)
p2 (G) P= 5.9e-44 P= 1.4e-16 P= 0.54

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
TT TC CC TC CC N0 N1 N2
bmic3f=Normal 1 0.86 (0.78-0.96) 1.07 (0.59-1.94) 0.86 (0.78-0.96) 1.07 (0.59-1.94) 10738.4/15720 809.5/1264 26.1/32
p0 P= 1 P= 0.0053 P= 0.82 P= 0.0053 P= 0.82
bmic3f=Overweight 1.11 (1.07-1.15) 1.16 (1.06-1.27) 1.41 (0.8-2.49) 1.04 (0.95-1.14) 1.27 (0.72-2.24) 13909.4/18959.9 1131.1/1366.4 32.5/30.7
p1 P= 3.7e-09 P= 0.0015 P= 0.24 P= 0.36 P= 0.42
bmic3f=Obese 1.35 (1.3-1.41) 1.63 (1.44-1.84) 1.5 (0.71-3.15) 1.21 (1.07-1.37) 1.11 (0.53-2.34) 8167.6/9708.4 697.2/640.5 20.3/17.1
p2 P= 3e-46 P= 7e-15 P= 0.29 P= 0.0031 P= 0.78
E param by G
bmic3f=Overweight(G) 1.11 (1.07-1.15) 1.34 (1.18-1.53) 1.31 (0.58-2.98)
p1 (G) P= 3.7e-09 P= 1.1e-05 P= 0.51
bmic3f=Obese(G) 1.35 (1.3-1.41) 1.89 (1.62-2.2) 1.4 (0.54-3.62)
p2 (G) P= 3e-46 P= 8.1e-16 P= 0.49

Locuszoom

Func Annot

chr15_33122966_C_T

Allele freq

GxE model by sex

sex stratified chr15_33122966_C_T_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr15_33122966_C_T_dose 1.501*** (1.352, 1.649) 1.521*** (1.329, 1.713) 1.456** (1.220, 1.691)
bmi5 1.178*** (1.159, 1.197) 1.139*** (1.114, 1.164) 1.240*** (1.210, 1.271)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.003, 1.008) 1.009*** (1.007, 1.011)
sex 1.110*** (1.078, 1.141)
chr15_33122966_C_T_dose:bmi5 0.939*** (0.913, 0.966) 0.939*** (0.904, 0.974) 0.944** (0.902, 0.987)
Constant 1.116 (0.709, 1.523) 0.360*** (0.127, 0.593) 0.850 (0.414, 1.287)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 4.9681e-06
GxE term LRtest p = 3.7163e-04
GxE term LRtest p = 7.9671e-03

GxE model by study design

study_design stratified chr15_33122966_C_T_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr15_33122966_C_T_dose 1.501*** (1.352, 1.649) 1.584*** (1.369, 1.799) 1.427*** (1.222, 1.632)
bmi5 1.178*** (1.159, 1.197) 1.180*** (1.152, 1.208) 1.175*** (1.149, 1.201)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.110*** (1.078, 1.141) 1.165*** (1.116, 1.214) 1.073*** (1.032, 1.114)
chr15_33122966_C_T_dose:bmi5 0.939*** (0.913, 0.966) 0.932*** (0.893, 0.971) 0.946** (0.909, 0.983)
Constant 1.116 (0.709, 1.523) 1.215 (0.766, 1.665) 0.274*** (0.064, 0.484)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 4.9681e-06
GxE term LRtest p = 4.0843e-04
GxE term LRtest p = 3.3760e-03

GxE model by tumor site

cancer_site_sum2 stratified chr15_33122966_C_T_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr15_33122966_C_T_dose 1.501*** (1.352, 1.649) 1.548*** (1.315, 1.782) 1.528*** (1.304, 1.751) 1.562*** (1.314, 1.810)
bmi5 1.178*** (1.159, 1.197) 1.237*** (1.207, 1.266) 1.183*** (1.155, 1.212) 1.124*** (1.092, 1.156)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.020*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.110*** (1.078, 1.141) 1.059* (1.009, 1.109) 0.843*** (0.794, 0.891) 1.299*** (1.248, 1.350)
chr15_33122966_C_T_dose:bmi5 0.939*** (0.913, 0.966) 0.931*** (0.889, 0.973) 0.935** (0.895, 0.975) 0.936** (0.891, 0.981)
Constant 1.116 (0.709, 1.523) 0.370*** (-0.164, 0.903) 0.165*** (-0.359, 0.690) 1.528 (1.056, 2.001)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 4.9681e-06
GxE term LRtest p = 7.3858e-04
GxE term LRtest p = 1.0582e-03
GxE term LRtest p = 3.8049e-03

Stratified OR

G param by E
Counts (Ca/Co)
CC CT TT CT TT N0 N1 N2
bmic3f=Normal 1 1.12 (1.06-1.18) 1.26 (1.12-1.43) 1.12 (1.06-1.18) 1.26 (1.12-1.43) 7382/11094.8 3938.6/5459 549.5/691.3
p0 P= 1 P= 4.3e-05 P= 0.0002 P= 4.3e-05 P= 0.0002
bmic3f=Overweight 1.13 (1.08-1.18) 1.25 (1.19-1.31) 1.28 (1.14-1.43) 1.1 (1.05-1.16) 1.13 (1.01-1.27) 9678.1/13327.5 5114.5/6524.9 665.5/826.6
p1 P= 7.7e-09 P= 4e-18 P= 1.7e-05 P= 5.8e-05 P= 0.029
bmic3f=Obese 1.45 (1.38-1.52) 1.43 (1.34-1.52) 1.26 (1.09-1.47) 0.99 (0.92-1.05) 0.87 (0.75-1.02) 5812.3/6625.6 2924.4/3436.3 350.2/465.1
p2 P= 3.9e-50 P= 2.9e-30 P= 0.0022 P= 0.65 P= 0.077
E param by G
bmic3f=Overweight(G) 1.13 (1.08-1.18) 1.12 (1.05-1.18) 1.02 (0.86-1.19)
p1 (G) P= 7.7e-09 P= 0.00021 P= 0.85
bmic3f=Obese(G) 1.45 (1.38-1.52) 1.28 (1.19-1.37) 1 (0.83-1.21)
p2 (G) P= 3.9e-50 P= 1.5e-12 P= 0.98

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
CC CT TT CT TT N0 N1 N2
bmic3f=Normal 1 1.11 (1.06-1.18) 1.28 (1.13-1.45) 1.11 (1.06-1.18) 1.28 (1.13-1.45) 7196.4/10942.9 3834.3/5391.8 543.3/681.3
p0 P= 1 P= 8.5e-05 P= 8.9e-05 P= 8.5e-05 P= 8.9e-05
bmic3f=Overweight 1.14 (1.09-1.19) 1.25 (1.19-1.32) 1.28 (1.15-1.44) 1.1 (1.05-1.15) 1.13 (1.01-1.26) 9441.2/13112.5 4987.3/6432.6 644.5/811.9
p1 P= 1.5e-09 P= 2.4e-18 P= 1.7e-05 P= 0.00012 P= 0.038
bmic3f=Obese 1.46 (1.39-1.54) 1.44 (1.36-1.54) 1.29 (1.11-1.5) 0.99 (0.93-1.05) 0.88 (0.76-1.03) 5680.3/6533.6 2860.4/3376.3 344.2/456.1
p2 P= 4.2e-51 P= 2.4e-31 P= 0.00098 P= 0.72 P= 0.11
E param by G
bmic3f=Overweight(G) 1.14 (1.09-1.19) 1.12 (1.06-1.19) 1 (0.85-1.18)
p1 (G) P= 1.5e-09 P= 9.6e-05 P= 0.96
bmic3f=Obese(G) 1.46 (1.39-1.54) 1.3 (1.21-1.39) 1.01 (0.83-1.22)
p2 (G) P= 4.2e-51 P= 1.5e-13 P= 0.93

Locuszoom

Func Annot

chr2_10961902_T_C

Allele freq

GxE model by sex

sex stratified chr2_10961902_T_C_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr2_10961902_T_C_dose 1.359*** (1.224, 1.493) 1.389*** (1.215, 1.564) 1.308* (1.095, 1.520)
bmi5 1.185*** (1.165, 1.206) 1.150*** (1.123, 1.176) 1.246*** (1.214, 1.278)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.003, 1.008) 1.009*** (1.007, 1.011)
sex 1.110*** (1.078, 1.141)
chr2_10961902_T_C_dose:bmi5 0.942*** (0.918, 0.967) 0.938*** (0.906, 0.969) 0.949** (0.911, 0.987)
Constant 1.116 (0.707, 1.524) 0.359*** (0.121, 0.597) 0.860 (0.420, 1.301)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.5633e-06
GxE term LRtest p = 6.8194e-05
GxE term LRtest p = 7.3187e-03

GxE model by study design

study_design stratified chr2_10961902_T_C_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr2_10961902_T_C_dose 1.359*** (1.224, 1.493) 1.360** (1.164, 1.556) 1.359** (1.173, 1.544)
bmi5 1.185*** (1.165, 1.206) 1.184*** (1.154, 1.213) 1.186*** (1.158, 1.214)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.110*** (1.078, 1.141) 1.165*** (1.116, 1.214) 1.073*** (1.033, 1.114)
chr2_10961902_T_C_dose:bmi5 0.942*** (0.918, 0.967) 0.941*** (0.906, 0.977) 0.943*** (0.910, 0.976)
Constant 1.116 (0.707, 1.524) 1.241 (0.788, 1.693) 0.270*** (0.053, 0.486)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.5633e-06
GxE term LRtest p = 8.2868e-04
GxE term LRtest p = 5.6437e-04

GxE model by tumor site

cancer_site_sum2 stratified chr2_10961902_T_C_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr2_10961902_T_C_dose 1.359*** (1.224, 1.493) 1.308* (1.096, 1.519) 1.566*** (1.362, 1.771) 1.253 (1.026, 1.480)
bmi5 1.185*** (1.165, 1.206) 1.237*** (1.205, 1.268) 1.207*** (1.177, 1.237) 1.121*** (1.086, 1.155)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.020*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.110*** (1.078, 1.141) 1.059* (1.009, 1.109) 0.843*** (0.794, 0.891) 1.300*** (1.249, 1.350)
chr2_10961902_T_C_dose:bmi5 0.942*** (0.918, 0.967) 0.948** (0.910, 0.986) 0.916*** (0.879, 0.953) 0.956* (0.915, 0.998)
Constant 1.116 (0.707, 1.524) 0.382*** (-0.154, 0.918) 0.155*** (-0.372, 0.683) 1.608 (1.130, 2.085)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.5633e-06
GxE term LRtest p = 5.2914e-03
GxE term LRtest p = 2.9088e-06
GxE term LRtest p = 3.3274e-02

Stratified OR

G param by E
Counts (Ca/Co)
TT TC CC TC CC N0 N1 N2
bmic3f=Normal 1 1.02 (0.97-1.08) 1.03 (0.93-1.13) 1.02 (0.97-1.08) 1.03 (0.93-1.13) 6390/9412.3 4621.9/6605.9 858.1/1226.8
p0 P= 1 P= 0.39 P= 0.56 P= 0.39 P= 0.56
bmic3f=Overweight 1.14 (1.09-1.2) 1.12 (1.06-1.17) 1.15 (1.05-1.25) 0.98 (0.93-1.02) 1.01 (0.92-1.1) 8331.7/11075.1 5968.5/8062.2 1157.8/1541.7
p1 P= 7e-09 P= 1e-05 P= 0.0017 P= 0.32 P= 0.89
bmic3f=Obese 1.45 (1.38-1.53) 1.34 (1.26-1.42) 1.2 (1.07-1.35) 0.92 (0.87-0.98) 0.83 (0.74-0.93) 4967.1/5535.6 3484.8/4165.2 635.1/826.2
p2 P= 5e-43 P= 2.8e-22 P= 0.0015 P= 0.01 P= 0.0018
E param by G
bmic3f=Overweight(G) 1.14 (1.09-1.2) 1.09 (1.03-1.15) 1.12 (0.99-1.26)
p1 (G) P= 7e-09 P= 0.0013 P= 0.075
bmic3f=Obese(G) 1.45 (1.38-1.53) 1.31 (1.23-1.39) 1.17 (1.01-1.35)
p2 (G) P= 5e-43 P= 3.8e-17 P= 0.031

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
TT TC CC TC CC N0 N1 N2
bmic3f=Normal 1 1.02 (0.97-1.08) 1.03 (0.93-1.13) 1.02 (0.97-1.08) 1.03 (0.93-1.13) 6232/9280.7 4508.2/6521.6 833.9/1213.8
p0 P= 1 P= 0.42 P= 0.59 P= 0.42 P= 0.59
bmic3f=Overweight 1.15 (1.1-1.2) 1.12 (1.07-1.18) 1.15 (1.05-1.25) 0.98 (0.93-1.02) 1 (0.91-1.09) 8136.1/10909.1 5820/7932.2 1116.9/1515.7
p1 P= 1.8e-09 P= 4.8e-06 P= 0.0024 P= 0.3 P= 0.95
bmic3f=Obese 1.46 (1.39-1.54) 1.35 (1.27-1.43) 1.2 (1.07-1.35) 0.92 (0.87-0.98) 0.82 (0.73-0.92) 4859/5447.7 3405.9/4101.4 620/816.9
p2 P= 5.2e-44 P= 1.9e-23 P= 0.0018 P= 0.014 P= 0.0011
E param by G
bmic3f=Overweight(G) 1.15 (1.1-1.2) 1.1 (1.04-1.16) 1.12 (0.99-1.26)
p1 (G) P= 1.8e-09 P= 0.00061 P= 0.08
bmic3f=Obese(G) 1.46 (1.39-1.54) 1.32 (1.24-1.41) 1.17 (1.01-1.35)
p2 (G) P= 5.2e-44 P= 2.5e-18 P= 0.033

Locuszoom

Func Annot

chr2_217410559_G_A

Allele freq

GxE model by sex

sex stratified chr2_217410559_G_A_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr2_217410559_G_A_dose 2.182*** (1.833, 2.531) 2.238*** (1.785, 2.691) 2.037* (1.484, 2.590)
bmi5 1.159*** (1.143, 1.175) 1.122*** (1.101, 1.142) 1.222*** (1.197, 1.247)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.003, 1.008) 1.009*** (1.007, 1.011)
sex 1.110*** (1.078, 1.141)
chr2_217410559_G_A_dose:bmi5 0.859*** (0.796, 0.922) 0.854*** (0.772, 0.936) 0.870** (0.771, 0.970)
Constant 1.247 (0.844, 1.650) 0.407*** (0.186, 0.628) 0.946 (0.519, 1.372)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 2.1518e-06
GxE term LRtest p = 1.5376e-04
GxE term LRtest p = 6.2497e-03

GxE model by study design

study_design stratified chr2_217410559_G_A_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr2_217410559_G_A_dose 2.182*** (1.833, 2.531) 2.100** (1.576, 2.625) 2.244*** (1.776, 2.712)
bmi5 1.159*** (1.143, 1.175) 1.155*** (1.132, 1.179) 1.161*** (1.139, 1.183)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.110*** (1.078, 1.141) 1.165*** (1.116, 1.214) 1.074*** (1.033, 1.115)
chr2_217410559_G_A_dose:bmi5 0.859*** (0.796, 0.922) 0.866** (0.771, 0.961) 0.854*** (0.770, 0.938)
Constant 1.247 (0.844, 1.650) 1.394 (0.952, 1.835) 0.301*** (0.106, 0.497)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 2.1518e-06
GxE term LRtest p = 2.7869e-03
GxE term LRtest p = 2.4341e-04

GxE model by tumor site

cancer_site_sum2 stratified chr2_217410559_G_A_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr2_217410559_G_A_dose 2.182*** (1.833, 2.531) 3.340*** (2.779, 3.901) 1.473 (0.941, 2.005) 2.480** (1.875, 3.086)
bmi5 1.159*** (1.143, 1.175) 1.219*** (1.194, 1.244) 1.158*** (1.134, 1.182) 1.106*** (1.079, 1.133)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.019*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.110*** (1.078, 1.141) 1.059* (1.009, 1.109) 0.843*** (0.795, 0.892) 1.300*** (1.249, 1.351)
chr2_217410559_G_A_dose:bmi5 0.859*** (0.796, 0.922) 0.793*** (0.691, 0.895) 0.920 (0.825, 1.015) 0.839** (0.729, 0.950)
Constant 1.247 (0.844, 1.650) 0.408*** (-0.117, 0.934) 0.191*** (-0.326, 0.708) 1.710* (1.247, 2.173)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 2.1518e-06
GxE term LRtest p = 4.7942e-06
GxE term LRtest p = 8.4947e-02
GxE term LRtest p = 1.5612e-03

Stratified OR

G param by E
Counts (Ca/Co)
GG GA AA GA AA N0 N1 N2
bmic3f=Normal 1 1.09 (0.98-1.21) 1.1 (0.51-2.35) 1.09 (0.98-1.21) 1.1 (0.51-2.35) 11113.9/16250.3 741.7/977.2 14.4/17.5
p0 P= 1 P= 0.1 P= 0.81 P= 0.1 P= 0.81
bmic3f=Overweight 1.13 (1.09-1.17) 1.08 (0.98-1.19) 0.75 (0.37-1.52) 0.96 (0.87-1.05) 0.66 (0.32-1.35) 14534.9/19428.4 909.1/1230.2 14/20.4
p1 P= 3.5e-12 P= 0.11 P= 0.42 P= 0.37 P= 0.25
bmic3f=Obese 1.4 (1.34-1.46) 1.11 (0.98-1.26) 0.73 (0.29-1.81) 0.8 (0.7-0.9) 0.52 (0.21-1.29) 8568.4/9829.8 510.5/682.8 8.1/14.4
p2 P= 1.7e-59 P= 0.098 P= 0.49 P= 0.00044 P= 0.16
E param by G
bmic3f=Overweight(G) 1.13 (1.09-1.17) 0.99 (0.86-1.14) 0.68 (0.24-1.92)
p1 (G) P= 3.5e-12 P= 0.89 P= 0.47
bmic3f=Obese(G) 1.4 (1.34-1.46) 1.02 (0.87-1.2) 0.66 (0.2-2.16)
p2 (G) P= 1.7e-59 P= 0.83 P= 0.49

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
GG GA AA GA AA N0 N1 N2
bmic3f=Normal 1 1.1 (0.99-1.22) 1.13 (0.53-2.41) 1.1 (0.99-1.22) 1.13 (0.53-2.41) 10833.5/16034.6 726.1/963.9 14.4/17.5
p0 P= 1 P= 0.082 P= 0.76 P= 0.082 P= 0.76
bmic3f=Overweight 1.14 (1.1-1.18) 1.09 (0.99-1.2) 0.77 (0.37-1.58) 0.96 (0.87-1.05) 0.67 (0.33-1.38) 14170/19123.5 889/1214.1 14/19.4
p1 P= 4e-13 P= 0.092 P= 0.47 P= 0.35 P= 0.28
bmic3f=Obese 1.41 (1.36-1.47) 1.11 (0.98-1.26) 0.85 (0.34-2.15) 0.79 (0.69-0.9) 0.6 (0.24-1.52) 8382.7/9680.9 494.2/671.7 8.1/13.4
p2 P= 8.2e-62 P= 0.11 P= 0.73 P= 0.00028 P= 0.28
E param by G
bmic3f=Overweight(G) 1.14 (1.1-1.18) 0.99 (0.86-1.14) 0.68 (0.24-1.94)
p1 (G) P= 4e-13 P= 0.87 P= 0.47
bmic3f=Obese(G) 1.41 (1.36-1.47) 1.01 (0.86-1.19) 0.76 (0.23-2.5)
p2 (G) P= 8.2e-62 P= 0.9 P= 0.65

Locuszoom

Func Annot

chr3_100037644_A_G

Allele freq

GxE model by sex

sex stratified chr3_100037644_A_G_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr3_100037644_A_G_dose 1.376*** (1.241, 1.512) 1.355*** (1.178, 1.532) 1.409** (1.195, 1.623)
bmi5 1.188*** (1.167, 1.208) 1.146*** (1.119, 1.173) 1.257*** (1.224, 1.289)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.003, 1.008) 1.009*** (1.007, 1.011)
sex 1.110*** (1.079, 1.142)
chr3_100037644_A_G_dose:bmi5 0.942*** (0.917, 0.966) 0.945*** (0.913, 0.977) 0.937*** (0.898, 0.975)
Constant 1.097 (0.687, 1.506) 0.360*** (0.119, 0.601) 0.818 (0.375, 1.260)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.5427e-06
GxE term LRtest p = 5.9801e-04
GxE term LRtest p = 8.6449e-04

GxE model by study design

study_design stratified chr3_100037644_A_G_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr3_100037644_A_G_dose 1.376*** (1.241, 1.512) 1.314** (1.117, 1.511) 1.439*** (1.251, 1.627)
bmi5 1.188*** (1.167, 1.208) 1.182*** (1.152, 1.213) 1.191*** (1.163, 1.220)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.110*** (1.079, 1.142) 1.165*** (1.116, 1.214) 1.074*** (1.033, 1.115)
chr3_100037644_A_G_dose:bmi5 0.942*** (0.917, 0.966) 0.946** (0.910, 0.982) 0.937*** (0.904, 0.971)
Constant 1.097 (0.687, 1.506) 1.256 (0.801, 1.711) 0.259*** (0.038, 0.479)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.5427e-06
GxE term LRtest p = 2.2744e-03
GxE term LRtest p = 1.8727e-04

GxE model by tumor site

cancer_site_sum2 stratified chr3_100037644_A_G_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr3_100037644_A_G_dose 1.376*** (1.241, 1.512) 1.361** (1.146, 1.576) 1.339** (1.134, 1.544) 1.433** (1.203, 1.663)
bmi5 1.188*** (1.167, 1.208) 1.243*** (1.211, 1.275) 1.187*** (1.155, 1.218) 1.137*** (1.102, 1.172)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.019*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.110*** (1.079, 1.142) 1.060* (1.011, 1.110) 0.844*** (0.795, 0.892) 1.301*** (1.250, 1.352)
chr3_100037644_A_G_dose:bmi5 0.942*** (0.917, 0.966) 0.941** (0.902, 0.979) 0.948** (0.911, 0.985) 0.934** (0.892, 0.975)
Constant 1.097 (0.687, 1.506) 0.375*** (-0.163, 0.913) 0.166*** (-0.363, 0.696) 1.485 (1.006, 1.965)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 1.5427e-06
GxE term LRtest p = 1.8201e-03
GxE term LRtest p = 4.6890e-03
GxE term LRtest p = 1.2279e-03

Stratified OR

G param by E
Counts (Ca/Co)
AA AG GG AG GG N0 N1 N2
bmic3f=Normal 1 1.03 (0.98-1.09) 1.19 (1.08-1.31) 1.03 (0.98-1.09) 1.19 (1.08-1.31) 6172.5/9201.1 4726.8/6798.9 970.7/1244.9
p0 P= 1 P= 0.21 P= 0.00042 P= 0.21 P= 0.00042
bmic3f=Overweight 1.17 (1.11-1.22) 1.14 (1.08-1.2) 1.11 (1.02-1.22) 0.98 (0.93-1.03) 0.95 (0.87-1.04) 8120.4/10805.7 6168.1/8276.2 1169.5/1597.1
p1 P= 9.4e-11 P= 2.2e-07 P= 0.019 P= 0.36 P= 0.29
bmic3f=Obese 1.49 (1.41-1.57) 1.33 (1.26-1.41) 1.29 (1.15-1.45) 0.9 (0.84-0.96) 0.87 (0.77-0.98) 4880.3/5388.9 3512.7/4284.4 694/853.6
p2 P= 1.3e-46 P= 3.5e-21 P= 1.2e-05 P= 0.00088 P= 0.019
E param by G
bmic3f=Overweight(G) 1.17 (1.11-1.22) 1.1 (1.04-1.16) 0.93 (0.83-1.06)
p1 (G) P= 9.4e-11 P= 0.00037 P= 0.27
bmic3f=Obese(G) 1.49 (1.41-1.57) 1.29 (1.21-1.37) 1.09 (0.94-1.25)
p2 (G) P= 1.3e-46 P= 3e-15 P= 0.26

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
AA AG GG AG GG N0 N1 N2
bmic3f=Normal 1 1.03 (0.98-1.09) 1.19 (1.08-1.31) 1.03 (0.98-1.09) 1.19 (1.08-1.31) 6031.6/9083.1 4594/6702.3 948.4/1230.6
p0 P= 1 P= 0.29 P= 0.00064 P= 0.29 P= 0.00064
bmic3f=Overweight 1.17 (1.12-1.23) 1.14 (1.09-1.2) 1.12 (1.03-1.23) 0.98 (0.93-1.02) 0.96 (0.88-1.05) 7926.7/10643.2 6004.2/8143.5 1142.1/1570.2
p1 P= 4.2e-11 P= 1.9e-07 P= 0.011 P= 0.32 P= 0.37
bmic3f=Obese 1.49 (1.41-1.58) 1.35 (1.27-1.43) 1.3 (1.16-1.46) 0.9 (0.84-0.96) 0.87 (0.77-0.98) 4769.8/5313.3 3435.2/4212.8 680/839.9
p2 P= 8.4e-47 P= 3.3e-22 P= 8e-06 P= 0.0018 P= 0.022
E param by G
bmic3f=Overweight(G) 1.17 (1.12-1.23) 1.11 (1.05-1.17) 0.95 (0.84-1.07)
p1 (G) P= 4.2e-11 P= 0.00016 P= 0.4
bmic3f=Obese(G) 1.49 (1.41-1.58) 1.31 (1.23-1.39) 1.1 (0.95-1.27)
p2 (G) P= 8.4e-47 P= 1.4e-16 P= 0.2

Locuszoom

Func Annot

chr6_138766021_C_T

Allele freq

GxE model by sex

sex stratified chr6_138766021_C_T_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr6_138766021_C_T_dose 0.537*** (0.276, 0.798) 0.616** (0.277, 0.954) 0.453*** (0.040, 0.866)
bmi5 1.131*** (1.115, 1.148) 1.098*** (1.076, 1.119) 1.189*** (1.162, 1.215)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.004, 1.008) 1.009*** (1.007, 1.011)
sex 1.111*** (1.079, 1.142)
chr6_138766021_C_T_dose:bmi5 1.120*** (1.073, 1.167) 1.095** (1.034, 1.157) 1.153*** (1.079, 1.228)
Constant 1.415 (1.012, 1.819) 0.454*** (0.231, 0.678) 1.095 (0.667, 1.524)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 2.1947e-06
GxE term LRtest p = 3.5392e-03
GxE term LRtest p = 1.5879e-04

GxE model by study design

study_design stratified chr6_138766021_C_T_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr6_138766021_C_T_dose 0.537*** (0.276, 0.798) 0.628* (0.248, 1.008) 0.468*** (0.108, 0.828)
bmi5 1.131*** (1.115, 1.148) 1.132*** (1.108, 1.157) 1.129*** (1.106, 1.152)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.111*** (1.079, 1.142) 1.166*** (1.117, 1.215) 1.075*** (1.034, 1.115)
chr6_138766021_C_T_dose:bmi5 1.120*** (1.073, 1.167) 1.097** (1.028, 1.166) 1.141*** (1.076, 1.206)
Constant 1.415 (1.012, 1.819) 1.538 (1.096, 1.980) 0.351*** (0.152, 0.550)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 2.1947e-06
GxE term LRtest p = 8.2124e-03
GxE term LRtest p = 5.8576e-05

GxE model by tumor site

cancer_site_sum2 stratified chr6_138766021_C_T_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr6_138766021_C_T_dose 0.537*** (0.276, 0.798) 0.419*** (0.009, 0.828) 0.630* (0.242, 1.017) 0.466*** (0.031, 0.901)
bmi5 1.131*** (1.115, 1.148) 1.178*** (1.152, 1.204) 1.139*** (1.114, 1.164) 1.073*** (1.045, 1.102)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.020*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.111*** (1.079, 1.142) 1.061* (1.011, 1.111) 0.844*** (0.795, 0.892) 1.302*** (1.251, 1.353)
chr6_138766021_C_T_dose:bmi5 1.120*** (1.073, 1.167) 1.163*** (1.091, 1.236) 1.092* (1.022, 1.162) 1.151*** (1.073, 1.229)
Constant 1.415 (1.012, 1.819) 0.496** (-0.031, 1.023) 0.207*** (-0.311, 0.725) 1.996** (1.531, 2.461)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 2.1947e-06
GxE term LRtest p = 4.5510e-05
GxE term LRtest p = 1.4042e-02
GxE term LRtest p = 4.5596e-04

Stratified OR

G param by E
Counts (Ca/Co)
CC CT TT CT TT N0 N1 N2
bmic3f=Normal 1 0.91 (0.84-0.99) 0.7 (0.46-1.08) 0.91 (0.84-0.99) 0.7 (0.46-1.08) 10452.8/15081.3 1372/2079.8 45.2/83.8
p0 P= 1 P= 0.024 P= 0.1 P= 0.024 P= 0.1
bmic3f=Overweight 1.11 (1.07-1.15) 1.1 (1.02-1.18) 1.02 (0.69-1.48) 0.99 (0.92-1.06) 0.92 (0.63-1.34) 13552.5/18192.6 1841.3/2395 64.1/91.4
p1 P= 1.9e-08 P= 0.014 P= 0.94 P= 0.75 P= 0.65
bmic3f=Obese 1.32 (1.27-1.38) 1.56 (1.41-1.71) 2.33 (1.34-4.05) 1.17 (1.06-1.3) 1.76 (1.01-3.06) 7897.4/9352.7 1143.3/1143.4 46.4/30.9
p2 P= 2.3e-39 P= 3.5e-19 P= 0.0026 P= 0.0016 P= 0.045
E param by G
bmic3f=Overweight(G) 1.11 (1.07-1.15) 1.2 (1.09-1.33) 1.45 (0.82-2.56)
p1 (G) P= 1.9e-08 P= 0.00037 P= 0.2
bmic3f=Obese(G) 1.32 (1.27-1.38) 1.71 (1.51-1.93) 3.32 (1.66-6.67)
p2 (G) P= 2.3e-39 P= 2.2e-18 P= 0.00072

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
CC CT TT CT TT N0 N1 N2
bmic3f=Normal 1 0.91 (0.84-0.99) 0.7 (0.45-1.07) 0.91 (0.84-0.99) 0.7 (0.45-1.07) 10188.6/14885.9 1340.3/2046.3 45.1/83.8
p0 P= 1 P= 0.033 P= 0.099 P= 0.033 P= 0.099
bmic3f=Overweight 1.11 (1.08-1.16) 1.11 (1.03-1.2) 1.03 (0.7-1.51) 1 (0.93-1.07) 0.92 (0.63-1.36) 13206.7/17914.7 1804.3/2353 62/89.3
p1 P= 4.6e-09 P= 0.0052 P= 0.89 P= 0.93 P= 0.68
bmic3f=Obese 1.34 (1.28-1.4) 1.58 (1.43-1.74) 2.31 (1.33-4.02) 1.18 (1.06-1.3) 1.73 (0.99-3.01) 7724/9214 1115.5/1121.3 45.5/30.7
p2 P= 3.7e-41 P= 8.6e-20 P= 0.003 P= 0.0015 P= 0.053
E param by G
bmic3f=Overweight(G) 1.11 (1.08-1.16) 1.22 (1.1-1.35) 1.47 (0.83-2.62)
p1 (G) P= 4.6e-09 P= 0.00021 P= 0.19
bmic3f=Obese(G) 1.34 (1.28-1.4) 1.72 (1.53-1.95) 3.32 (1.65-6.67)
p2 (G) P= 3.7e-41 P= 1.5e-18 P= 0.00077

Locuszoom

Func Annot

chr9_136601110_C_G

Allele freq

GxE model by sex

sex stratified chr9_136601110_C_G_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr9_136601110_C_G_dose 0.530*** (0.268, 0.792) 0.561*** (0.224, 0.898) 0.468*** (0.049, 0.887)
bmi5 1.130*** (1.113, 1.147) 1.094*** (1.072, 1.116) 1.189*** (1.163, 1.216)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.003, 1.008) 1.009*** (1.007, 1.011)
sex 1.110*** (1.079, 1.141)
chr9_136601110_C_G_dose:bmi5 1.118*** (1.071, 1.166) 1.110*** (1.049, 1.171) 1.141*** (1.065, 1.216)
Constant 1.433 (1.030, 1.837) 0.466*** (0.241, 0.690) 1.093 (0.665, 1.522)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 3.4901e-06
GxE term LRtest p = 8.2985e-04
GxE term LRtest p = 6.1030e-04

GxE model by study design

study_design stratified chr9_136601110_C_G_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr9_136601110_C_G_dose 0.530*** (0.268, 0.792) 0.538** (0.159, 0.917) 0.521*** (0.156, 0.885)
bmi5 1.130*** (1.113, 1.147) 1.130*** (1.105, 1.154) 1.129*** (1.105, 1.152)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.110*** (1.079, 1.141) 1.165*** (1.116, 1.214) 1.074*** (1.033, 1.115)
chr9_136601110_C_G_dose:bmi5 1.118*** (1.071, 1.166) 1.109** (1.040, 1.177) 1.128*** (1.062, 1.194)
Constant 1.433 (1.030, 1.837) 1.590* (1.147, 2.033) 0.349*** (0.149, 0.549)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 3.4901e-06
GxE term LRtest p = 3.1123e-03
GxE term LRtest p = 3.2050e-04

GxE model by tumor site

cancer_site_sum2 stratified chr9_136601110_C_G_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr9_136601110_C_G_dose 0.530*** (0.268, 0.792) 0.505*** (0.098, 0.912) 0.511*** (0.117, 0.905) 0.719 (0.276, 1.162)
bmi5 1.130*** (1.113, 1.147) 1.180*** (1.153, 1.206) 1.133*** (1.107, 1.158) 1.084*** (1.056, 1.113)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.020*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.110*** (1.079, 1.141) 1.060* (1.010, 1.110) 0.844*** (0.795, 0.892) 1.300*** (1.249, 1.351)
chr9_136601110_C_G_dose:bmi5 1.118*** (1.071, 1.166) 1.131*** (1.059, 1.204) 1.125** (1.054, 1.196) 1.063 (0.983, 1.144)
Constant 1.433 (1.030, 1.837) 0.488** (-0.040, 1.016) 0.216*** (-0.303, 0.735) 1.899** (1.434, 2.365)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 3.4901e-06
GxE term LRtest p = 8.8246e-04
GxE term LRtest p = 1.1910e-03
GxE term LRtest p = 1.3749e-01

Stratified OR

G param by E
Counts (Ca/Co)
CC CG GG CG GG N0 N1 N2
bmic3f=Normal 1 0.86 (0.79-0.94) 0.62 (0.42-0.93) 0.86 (0.79-0.94) 0.62 (0.42-0.93) 10340.4/14811.9 1474/2328.3 55.7/104.7
p0 P= 1 P= 0.00045 P= 0.022 P= 0.00045 P= 0.022
bmic3f=Overweight 1.1 (1.06-1.14) 1.1 (1.02-1.18) 1.01 (0.69-1.48) 1 (0.93-1.08) 0.92 (0.63-1.35) 13350.1/17911.5 2035.3/2661.1 72.6/106.4
p1 P= 7.1e-07 P= 0.011 P= 0.96 P= 0.95 P= 0.67
bmic3f=Obese 1.31 (1.26-1.37) 1.53 (1.38-1.68) 1.46 (0.88-2.44) 1.16 (1.05-1.28) 1.11 (0.67-1.85) 7802.8/9196 1233.7/1274.8 50.5/56.2
p2 P= 3.3e-36 P= 1.4e-17 P= 0.15 P= 0.0038 P= 0.68
E param by G
bmic3f=Overweight(G) 1.1 (1.06-1.14) 1.27 (1.15-1.41) 1.61 (0.93-2.82)
p1 (G) P= 7.1e-07 P= 3.3e-06 P= 0.092
bmic3f=Obese(G) 1.31 (1.26-1.37) 1.77 (1.57-2) 2.34 (1.22-4.48)
p2 (G) P= 3.3e-36 P= 1.6e-20 P= 0.01

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
CC CG GG CG GG N0 N1 N2
bmic3f=Normal 1 0.86 (0.8-0.94) 0.62 (0.41-0.93) 0.86 (0.8-0.94) 0.62 (0.41-0.93) 10084.6/14620.4 1435.3/2292.5 54.1/103.1
p0 P= 1 P= 0.00063 P= 0.022 P= 0.00063 P= 0.022
bmic3f=Overweight 1.1 (1.06-1.15) 1.1 (1.03-1.19) 1.01 (0.69-1.5) 1 (0.93-1.08) 0.92 (0.62-1.36) 13015/17630 1986.9/2621.6 71.1/105.4
p1 P= 1.4e-07 P= 0.0086 P= 0.94 P= 1 P= 0.67
bmic3f=Obese 1.33 (1.27-1.38) 1.55 (1.41-1.71) 1.5 (0.9-2.5) 1.17 (1.06-1.3) 1.13 (0.68-1.88) 7625.8/9058.9 1208.9/1250.9 50.3/56.1
p2 P= 1.3e-37 P= 1.4e-18 P= 0.12 P= 0.0023 P= 0.64
E param by G
bmic3f=Overweight(G) 1.1 (1.06-1.15) 1.28 (1.15-1.42) 1.63 (0.93-2.87)
p1 (G) P= 1.4e-07 P= 3.4e-06 P= 0.088
bmic3f=Obese(G) 1.33 (1.27-1.38) 1.8 (1.59-2.03) 2.41 (1.25-4.63)
p2 (G) P= 1.3e-37 P= 3.7e-21 P= 0.0084

Locuszoom

Func Annot

Two-step findings

chr15_33120215_T_C

Allele freq

GxE model by sex

sex stratified chr15_33120215_T_C_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr15_33120215_T_C_dose 1.497*** (1.349, 1.646) 1.509*** (1.317, 1.702) 1.466** (1.231, 1.702)
bmi5 1.178*** (1.159, 1.197) 1.138*** (1.114, 1.163) 1.241*** (1.211, 1.272)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.003, 1.008) 1.009*** (1.007, 1.011)
sex 1.110*** (1.078, 1.141)
chr15_33120215_T_C_dose:bmi5 0.940*** (0.913, 0.966) 0.940*** (0.905, 0.975) 0.942** (0.900, 0.985)
Constant 1.117 (0.710, 1.524) 0.361*** (0.128, 0.594) 0.847 (0.411, 1.284)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 5.2723e-06
GxE term LRtest p = 5.1191e-04
GxE term LRtest p = 6.1458e-03

GxE model by study design

study_design stratified chr15_33120215_T_C_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr15_33120215_T_C_dose 1.497*** (1.349, 1.646) 1.574*** (1.359, 1.789) 1.429*** (1.224, 1.634)
bmi5 1.178*** (1.159, 1.197) 1.179*** (1.151, 1.207) 1.175*** (1.149, 1.201)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.110*** (1.078, 1.141) 1.165*** (1.116, 1.214) 1.073*** (1.032, 1.114)
chr15_33120215_T_C_dose:bmi5 0.940*** (0.913, 0.966) 0.933*** (0.894, 0.972) 0.946** (0.909, 0.983)
Constant 1.117 (0.710, 1.524) 1.219 (0.770, 1.668) 0.274*** (0.063, 0.484)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 5.2723e-06
GxE term LRtest p = 4.8718e-04
GxE term LRtest p = 3.0959e-03

GxE model by tumor site

cancer_site_sum2 stratified chr15_33120215_T_C_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr15_33120215_T_C_dose 1.497*** (1.349, 1.646) 1.570*** (1.337, 1.804) 1.533*** (1.310, 1.756) 1.521*** (1.273, 1.769)
bmi5 1.178*** (1.159, 1.197) 1.238*** (1.209, 1.268) 1.184*** (1.155, 1.212) 1.122*** (1.090, 1.154)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.020*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.110*** (1.078, 1.141) 1.059* (1.009, 1.109) 0.843*** (0.794, 0.891) 1.299*** (1.248, 1.350)
chr15_33120215_T_C_dose:bmi5 0.940*** (0.913, 0.966) 0.928*** (0.886, 0.970) 0.935** (0.894, 0.975) 0.940** (0.895, 0.985)
Constant 1.117 (0.710, 1.524) 0.368*** (-0.166, 0.901) 0.165*** (-0.359, 0.690) 1.544 (1.072, 2.017)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 5.2723e-06
GxE term LRtest p = 4.2147e-04
GxE term LRtest p = 9.8524e-04
GxE term LRtest p = 6.8539e-03

Stratified OR

G param by E
Counts (Ca/Co)
TT TC CC TC CC N0 N1 N2
bmic3f=Normal 1 1.12 (1.06-1.18) 1.26 (1.12-1.43) 1.12 (1.06-1.18) 1.26 (1.12-1.43) 7377.6/11093.1 3945.3/5466.8 547.1/685.2
p0 P= 1 P= 4.5e-05 P= 0.00017 P= 4.5e-05 P= 0.00017
bmic3f=Overweight 1.13 (1.09-1.18) 1.24 (1.18-1.31) 1.28 (1.14-1.43) 1.1 (1.05-1.15) 1.13 (1.01-1.26) 9679.6/13323.4 5112.1/6527.7 666.4/827.9
p1 P= 5.7e-09 P= 7.8e-18 P= 1.7e-05 P= 9.7e-05 P= 0.031
bmic3f=Obese 1.45 (1.38-1.52) 1.42 (1.34-1.51) 1.27 (1.09-1.47) 0.98 (0.92-1.05) 0.87 (0.75-1.02) 5818.6/6629.1 2916.2/3432.6 352.2/465.3
p2 P= 1.9e-50 P= 7.2e-30 P= 0.0019 P= 0.57 P= 0.079
E param by G
bmic3f=Overweight(G) 1.13 (1.09-1.18) 1.11 (1.05-1.18) 1.01 (0.86-1.19)
p1 (G) P= 5.7e-09 P= 0.00026 P= 0.88
bmic3f=Obese(G) 1.45 (1.38-1.52) 1.28 (1.19-1.37) 1 (0.83-1.21)
p2 (G) P= 1.9e-50 P= 2.3e-12 P= 0.98

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
TT TC CC TC CC N0 N1 N2
bmic3f=Normal 1 1.11 (1.06-1.17) 1.28 (1.13-1.45) 1.11 (1.06-1.17) 1.28 (1.13-1.45) 7192.5/10942.2 3840.6/5398.7 541/675.2
p0 P= 1 P= 8.5e-05 P= 7.7e-05 P= 8.5e-05 P= 7.7e-05
bmic3f=Overweight 1.14 (1.09-1.19) 1.25 (1.19-1.31) 1.28 (1.15-1.44) 1.1 (1.04-1.15) 1.13 (1.01-1.26) 9441.7/13108.8 4986/6435.1 645.4/813.1
p1 P= 1.2e-09 P= 4.1e-18 P= 1.7e-05 P= 0.00018 P= 0.039
bmic3f=Obese 1.46 (1.39-1.54) 1.44 (1.35-1.53) 1.29 (1.11-1.5) 0.99 (0.92-1.05) 0.88 (0.76-1.03) 5685.6/6537 2854.2/3372.6 345.2/456.3
p2 P= 2.1e-51 P= 4.6e-31 P= 0.00096 P= 0.65 P= 0.11
E param by G
bmic3f=Overweight(G) 1.14 (1.09-1.19) 1.12 (1.06-1.19) 1 (0.85-1.18)
p1 (G) P= 1.2e-09 P= 0.00012 P= 0.99
bmic3f=Obese(G) 1.46 (1.39-1.54) 1.29 (1.21-1.39) 1.01 (0.83-1.22)
p2 (G) P= 2.1e-51 P= 2.1e-13 P= 0.95

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chr15_33122966_C_T

Allele freq

GxE model by sex

sex stratified chr15_33122966_C_T_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Female (Ca=17139,Co=23717) Male (Ca=19276,Co=24734)
(1) (2) (3)
chr15_33122966_C_T_dose 1.501*** (1.352, 1.649) 1.521*** (1.329, 1.713) 1.456** (1.220, 1.691)
bmi5 1.178*** (1.159, 1.197) 1.139*** (1.114, 1.164) 1.240*** (1.210, 1.271)
age_ref_imp 1.007*** (1.006, 1.009) 1.006*** (1.003, 1.008) 1.009*** (1.007, 1.011)
sex 1.110*** (1.078, 1.141)
chr15_33122966_C_T_dose:bmi5 0.939*** (0.913, 0.966) 0.939*** (0.904, 0.974) 0.944** (0.902, 0.987)
Constant 1.116 (0.709, 1.523) 0.360*** (0.127, 0.593) 0.850 (0.414, 1.287)
Observations 84,866 40,856 44,010
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 4.9681e-06
GxE term LRtest p = 3.7163e-04
GxE term LRtest p = 7.9671e-03

GxE model by study design

study_design stratified chr15_33122966_C_T_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Cohort (Ca=15858,Co=28688) Case-Control (Ca=20557,Co=19763)
(1) (2) (3)
chr15_33122966_C_T_dose 1.501*** (1.352, 1.649) 1.584*** (1.369, 1.799) 1.427*** (1.222, 1.632)
bmi5 1.178*** (1.159, 1.197) 1.180*** (1.152, 1.208) 1.175*** (1.149, 1.201)
age_ref_imp 1.007*** (1.006, 1.009) 1.005*** (1.002, 1.008) 1.008*** (1.006, 1.010)
sex 1.110*** (1.078, 1.141) 1.165*** (1.116, 1.214) 1.073*** (1.032, 1.114)
chr15_33122966_C_T_dose:bmi5 0.939*** (0.913, 0.966) 0.932*** (0.893, 0.971) 0.946** (0.909, 0.983)
Constant 1.116 (0.709, 1.523) 1.215 (0.766, 1.665) 0.274*** (0.064, 0.484)
Observations 84,866 44,546 40,320
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 4.9681e-06
GxE term LRtest p = 4.0843e-04
GxE term LRtest p = 3.3760e-03

GxE model by tumor site

cancer_site_sum2 stratified chr15_33122966_C_T_dose x bmi5
Dependent variable:
outcome
All (Ca=36415,Co=48451) Proximal (Ca=9398,Co=48451) Distal (Ca=10928,Co=48451) Rectal (Ca=9200,Co=48451)
(1) (2) (3) (4)
chr15_33122966_C_T_dose 1.501*** (1.352, 1.649) 1.548*** (1.315, 1.782) 1.528*** (1.304, 1.751) 1.562*** (1.314, 1.810)
bmi5 1.178*** (1.159, 1.197) 1.237*** (1.207, 1.266) 1.183*** (1.155, 1.212) 1.124*** (1.092, 1.156)
age_ref_imp 1.007*** (1.006, 1.009) 0.997* (0.995, 1.000) 1.020*** (1.017, 1.022) 0.992*** (0.989, 0.994)
sex 1.110*** (1.078, 1.141) 1.059* (1.009, 1.109) 0.843*** (0.794, 0.891) 1.299*** (1.248, 1.350)
chr15_33122966_C_T_dose:bmi5 0.939*** (0.913, 0.966) 0.931*** (0.889, 0.973) 0.935** (0.895, 0.975) 0.936** (0.891, 0.981)
Constant 1.116 (0.709, 1.523) 0.370*** (-0.164, 0.903) 0.165*** (-0.359, 0.690) 1.528 (1.056, 2.001)
Observations 84,866 57,849 59,379 57,651
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 4.9681e-06
GxE term LRtest p = 7.3858e-04
GxE term LRtest p = 1.0582e-03
GxE term LRtest p = 3.8049e-03

Stratified OR

G param by E
Counts (Ca/Co)
CC CT TT CT TT N0 N1 N2
bmic3f=Normal 1 1.12 (1.06-1.18) 1.26 (1.12-1.43) 1.12 (1.06-1.18) 1.26 (1.12-1.43) 7382/11094.8 3938.6/5459 549.5/691.3
p0 P= 1 P= 4.3e-05 P= 0.0002 P= 4.3e-05 P= 0.0002
bmic3f=Overweight 1.13 (1.08-1.18) 1.25 (1.19-1.31) 1.28 (1.14-1.43) 1.1 (1.05-1.16) 1.13 (1.01-1.27) 9678.1/13327.5 5114.5/6524.9 665.5/826.6
p1 P= 7.7e-09 P= 4e-18 P= 1.7e-05 P= 5.8e-05 P= 0.029
bmic3f=Obese 1.45 (1.38-1.52) 1.43 (1.34-1.52) 1.26 (1.09-1.47) 0.99 (0.92-1.05) 0.87 (0.75-1.02) 5812.3/6625.6 2924.4/3436.3 350.2/465.1
p2 P= 3.9e-50 P= 2.9e-30 P= 0.0022 P= 0.65 P= 0.077
E param by G
bmic3f=Overweight(G) 1.13 (1.08-1.18) 1.12 (1.05-1.18) 1.02 (0.86-1.19)
p1 (G) P= 7.7e-09 P= 0.00021 P= 0.85
bmic3f=Obese(G) 1.45 (1.38-1.52) 1.28 (1.19-1.37) 1 (0.83-1.21)
p2 (G) P= 3.9e-50 P= 1.5e-12 P= 0.98

Stratified OR (adj smk_ever)

G param by E
Counts (Ca/Co)
CC CT TT CT TT N0 N1 N2
bmic3f=Normal 1 1.11 (1.06-1.18) 1.28 (1.13-1.45) 1.11 (1.06-1.18) 1.28 (1.13-1.45) 7196.4/10942.9 3834.3/5391.8 543.3/681.3
p0 P= 1 P= 8.5e-05 P= 8.9e-05 P= 8.5e-05 P= 8.9e-05
bmic3f=Overweight 1.14 (1.09-1.19) 1.25 (1.19-1.32) 1.28 (1.15-1.44) 1.1 (1.05-1.15) 1.13 (1.01-1.26) 9441.2/13112.5 4987.3/6432.6 644.5/811.9
p1 P= 1.5e-09 P= 2.4e-18 P= 1.7e-05 P= 0.00012 P= 0.038
bmic3f=Obese 1.46 (1.39-1.54) 1.44 (1.36-1.54) 1.29 (1.11-1.5) 0.99 (0.93-1.05) 0.88 (0.76-1.03) 5680.3/6533.6 2860.4/3376.3 344.2/456.1
p2 P= 4.2e-51 P= 2.4e-31 P= 0.00098 P= 0.72 P= 0.11
E param by G
bmic3f=Overweight(G) 1.14 (1.09-1.19) 1.12 (1.06-1.19) 1 (0.85-1.18)
p1 (G) P= 1.5e-09 P= 9.6e-05 P= 0.96
bmic3f=Obese(G) 1.46 (1.39-1.54) 1.3 (1.21-1.39) 1.01 (0.83-1.22)
p2 (G) P= 4.2e-51 P= 1.5e-13 P= 0.93

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3DF findings

All SNPs associated with BMI, no evidence of GxE (pvalue > 0.05), very small evidence of main effects

chr1_177889480_A_G

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chr12_50204089_G_A

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chr16_28649651_C_A

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chr16_53800954_T_C

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chr18_57850583_C_A

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chr18_57971625_A_G

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chr18_58083923_A_C

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chr19_47581242_C_T

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chr2_417167_T_C

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chr2_558080_G_T

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chr2_651365_G_A

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chr4_45181334_A_T

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